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Towards the Design and Implementation of Surface Tethered Quantum Dot-Based Nanosensors

Published online by Cambridge University Press:  01 February 2011

Igor L. Medintz ,
Kim E. Sapsford ,
Joel P. Golden ,
Aaron R. Clapp ,
Ellen R. Goldman  and
Hedi Mattoussi
Igor L. Medintz
Affiliation:
Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington DC 20375
Kim E. Sapsford
Affiliation:
George Mason University, 10910 University Blvd, MS 4E3, Manassas, VA 20110
Joel P. Golden
Affiliation:
Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington DC 20375
Aaron R. Clapp
Affiliation:
Division of Optical Sciences Code 5611, U.S. Naval Research Laboratory, Washington, DC, 20375
Ellen R. Goldman
Affiliation:
Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington DC 20375
Hedi Mattoussi
Affiliation:
Division of Optical Sciences Code 5611, U.S. Naval Research Laboratory, Washington, DC, 20375
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Abstract

Considerable progress has been made towards creating quantum dot (QD) based nanosensors. The most promising developments have utilized QDs as energy donor in fluorescence resonance energy transfer (FRET) processes. Hybrid QD-protein-dye complexes have been assembled to study FRET, to prototype analyte sensing and even to control or modulate QD photoluminescence. In order to transition the benefits of this technology into the field, QD-based nanosensors will have to be integrated into microtiter wells, flow cells, portable arrays and other portable devices. This proceeding describes two examples of QD-protein-dye assemblies. The first investigates the concepts of FRET applied to QD energy donors and the second describes a prototype biosensor employing QDs. We also introduce the first steps towards implementing surface-tethered QD-bioconjugates, which could potentially serve in the design of solid-state QD-based sensing assemblies.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 789 , 2003 , N5.4
Copyright
Copyright © Materials Research Society 2004

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Footnotes

*

Electronic address: imedintz@cbmse.nrl.navy.mil

References

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