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Use of clays using ursolic acid with anti-inflammatoryactivity

Published online by Cambridge University Press:  10 March 2011

M.L. Domínguez-Patiño
Affiliation:
Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, CP 62209,Cuernavaca, Morelos, México.
M. Chávez-Castillo
Affiliation:
Posgrado en Ingeniería y Ciencias Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, CP 62209,Cuernavaca, Morelos, México.
A. Rodríguez-Martínez
Affiliation:
Centro de Investigación en Ingeniería y Ciencias Aplicadas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, CP 62209, Cuernavaca, Morelos, México.
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Abstract

Today the company seeks alternative natural medicine that are compatiblewith the body, which does not produce side effects and hang time are easilyaccessible and cost of those who currently have. The concern of researchersand specialists in the development of new materials is to seek, toexperiment and create products that can be useful and compatible with humanbeings so as to obtain a curative effect without a side effectoriginates.

The development of pharmacologically active materials has increased inrecent years. People lack access to most drugs and is therefore a need formore rapid and less expensive than current, which can be applied to cellularsystems in vitro, in order to evaluate the biocompatibility of newmaterials. The current study seeks to experiment in a new line of researchthat helps health care and have a better quality of life.

The excipients in the drug are auxiliary substances that help the activeingredient is the one with the therapeutic action, can be formulated in aneffective and pleasant for the patient. It is one or more substances thatare incorporated into the product to facilitate its preparation, maintenanceor administration. We therefore tested clay known as bentonite to serve as avehicle for transport of an active substance (ursolic acid) [1] and somescientific studies have shown that it possesses anti-inflammatory,antibacterial, antifungal and highly cytotoxic capacity. Both materials weremixed to generate a new biomaterial that has anti-inflammatory activity.Evaluation of this model was under the inhibition of edema produced by13-acetate-12-ortho-tetradecanoylphorbol (TPA) in mouse ear.

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References

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