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Social influence on 5-year survival in a longitudinal chemotherapy ward co-presence network

Published online by Cambridge University Press:  12 July 2017

JEFFREY LIENERT
Affiliation:
National Human Genome Research Institute, NIH, Bethesda, MD, USA CABDyN Complexity Centre, Saïd Business School, University of Oxford, Oxford, UK (e-mail: jeff.lienert@nih.gov)
CHRISTOPHER STEVEN MARCUM
Affiliation:
National Human Genome Research Institute, NIH, Bethesda, MD, USA (e-mail: chris.marcum@nih.gov)
JOHN FINNEY
Affiliation:
Oxford University Hospitals, National Health Service, Oxford, UK (e-mail: john.finney@ndm.ox.ac.uk)
FELIX REED-TSOCHAS
Affiliation:
CABDyN Complexity Centre, Saïd Business School, University of Oxford, Oxford, UK The Oxford Martin School, University of Oxford, Oxford, UK (e-mail: felix.reed-tsochas@sbs.ox.ac.uk)
LAURA KOEHLY
Affiliation:
National Human Genome Research Institute, NIH, Bethesda, MD, USA (e-mail: koehlyl@mail.nih.gov)
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Abstract

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Chemotherapy is often administered in openly designed hospital wards, where the possibility of patient–patient social influence on health exists. Previous research found that social relationships influence cancer patient's health; however, we have yet to understand social influence among patients receiving chemotherapy in the hospital. We investigate the influence of co-presence in a chemotherapy ward. We use data on 4,691 cancer patients undergoing chemotherapy in Oxfordshire, United Kingdom who average 59.8 years of age, and 44% are Male. We construct a network of patients where edges exist when patients are co-present in the ward, weighted by both patients' time in the ward. Social influence is based on total weighted co-presence with focal patients' immediate neighbors, considering neighbors' 5-year mortality. Generalized estimating equations evaluated the effect of neighbors' 5-year mortality on focal patient's 5-year mortality. Each 1,000-unit increase in weighted co-presence with a patient who dies within 5 years increases a patient's mortality odds by 42% (β = 0.357, CI:0.204,0.510). Each 1,000-unit increase in co-presence with a patient surviving 5 years reduces a patient's odds of dying by 30% (β =−0.344, CI:−0.538,0.149). Our results suggest that social influence occurs in chemotherapy wards, and thus may need to be considered in chemotherapy delivery.

Type
Research Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © Cambridge University Press 2017

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