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Actigraphy as an assessment of performance status in patients with advanced lung cancer

Published online by Cambridge University Press:  11 February 2019

Daisuke Fujisawa Open the ORCID record for Daisuke Fujisawa [Opens in a new window] ,
Jennifer S. Temel ,
Joseph A. Greer ,
Areej El-Jawahri ,
Lara Traeger ,
Jamie M. Jacobs ,
Stacy Cutrono  and
William F. Pirl
Daisuke Fujisawa*
Affiliation:
Massachusetts General Hospital, Cancer Center, Boston, MA Keio University School of Medicine, Department of Neuropsychiatry and Palliative Care Center, Tokyo, Japan
Jennifer S. Temel
Affiliation:
Massachusetts General Hospital, Cancer Center, Boston, MA
Joseph A. Greer
Affiliation:
Massachusetts General Hospital, Cancer Center, Boston, MA
Areej El-Jawahri
Affiliation:
Massachusetts General Hospital, Cancer Center, Boston, MA
Lara Traeger
Affiliation:
Massachusetts General Hospital, Cancer Center, Boston, MA
Jamie M. Jacobs
Affiliation:
Massachusetts General Hospital, Cancer Center, Boston, MA
Stacy Cutrono
Affiliation:
Sylvester Comprehensive Cancer Center, Miami University, Miller School of Medicine, Miami, FL
William F. Pirl
Affiliation:
Massachusetts General Hospital, Cancer Center, Boston, MA Dana-Faber Cancer Institute, Psychosocial Oncology and Palliative Care, Boston, MA
*
Author for correspondence: Daisuke Fujisawa, Department of Neuropsychiatry and Palliative Care Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan. E-mail: dfujisawa@keio.jp
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Abstract

Objective

Wearable devices such as a wrist actigraph may have a potential to objectively estimate patients’ functioning and may supplement performance status (PS). This proof-of-concept study aimed to evaluate whether actigraphy data are significantly associated with patients’ functioning and are predictive of their survival in patients with metastatic non-small cell lung cancer.

Method

We collected actigraphy data for a three-day period in ambulatory patients with stage IV non-small cell lung cancer. We computed correlations between actigraphy data (specifically, proportion of time spent immobile while awake) and clinician-rated PS, subjective report of physical activities, quality of life (the Functional Assessment of Cancer Therapy – Trial Outcome Index), and survival.

Result

Actigraphy data (the proportion of time awake spent immobile) were significantly correlated with Functional Assessment of Cancer Therapy – Trial Outcome Index (r = −0.53, p < 0.001) and with the Eastern Cooperative Oncology Group PS (ECOG PS) (r = 0.37, p < 0.001). The proportion of time awake spent immobile was significantly associated with worse survival. For each 10% increase in this measure, the hazard ratio (HR) was 1.48 (95% confidence interval [CI95%] = 1.06, 2.06) for overall mortality, and odds ratio was 2.99 (CI95% = 1.27, 7.05) for six-month mortality. ECOG PS was also associated with worse survival (HR = 2.80, CI95% = 1.34, 5.86). Among patients with ECOG PS 0-1, the percentage of time awake spent immobile was significantly associated with worse survival, HR = 1.93 (CI95% = 1.10, 3.42), whereas ECOG PS did not predict survival.

Significance of Results

Actigraphy may have potential to predict important clinical outcomes, such as quality of life and survival, and may serve to supplement PS. Further validation study is warranted.

Keywords

ActigraphCancerPerformance statusPhysical activitySurvival

Information

Type
Original Article
Information
Palliative & Supportive Care , Volume 17 , Issue 5 , October 2019 , pp. 574 - 578
Copyright
Copyright © Cambridge University Press 2019 

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