Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 9
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Mücke, M. Conrad, R. Bleckwenn, M. Cuhls, H. Radbruch, L. and Rolke, R. 2016. Luftnot, Jucken und Depression in der Palliativmedizin. Der Schmerz, Vol. 30, Issue. 2, p. 193.


    Hutcheson, Sinead McMullan, Damien J Lundy, Emma Jackson, Neil and White, Clare 2015. Psychiatric conditions in palliative medicine. Medicine, Vol. 43, Issue. 12, p. 719.


    Kim, Yun Hee Lee, Seung Hun Lim, Ho Seop Choi, Young Jin Kim, Yun Jin Lee, Sang Yeoup Lee, Jeong Gyu Jeong, Dong Wook and Yu, Kyoung Hwa 2015. Family Caregivers' Quality of Life, Depression and Anxiety according to Symptom Control in Hospice Patients. Korean Journal of Hospice and Palliative Care, Vol. 18, Issue. 4, p. 314.


    Lie, H.C. Hjermstad, M.J. Fayers, P. Finset, A. Kaasa, S. and Loge, J.H. 2015. Depression in advanced cancer – Assessment challenges and associations with disease load. Journal of Affective Disorders, Vol. 173, p. 176.


    Ostuzzi, Giovanni Matcham, Faith Dauchy, Sarah Barbui, Corrado Hotopf, Matthew and Ostuzzi, Giovanni 2015. Cochrane Database of Systematic Reviews.


    Ostuzzi, Giovanni Benda, Laura Costa, Enrico and Barbui, Corrado 2015. Efficacy and acceptability of antidepressants on the continuum of depressive experiences in patients with cancer: Systematic review and meta-analysis. Cancer Treatment Reviews, Vol. 41, Issue. 8, p. 714.


    Reich, Michel 2015. Les troubles psychiatriques en soins palliatifs et en fin de vie. La Presse Médicale, Vol. 44, Issue. 4, p. 442.


    Zhang, Amy Y. Gary, Faye and Zhu, Hui 2015. Exploration of depressive symptoms in African American cancer patients. Journal of Mental Health, Vol. 24, Issue. 6, p. 351.


    Ostuzzi, Giovanni Matcham, Faith Dauchy, Sarah Barbui, Corrado Hotopf, Matthew and Ostuzzi, Giovanni 2014. Cochrane Database of Systematic Reviews.


    ×

Depressed patients with incurable cancer: Which depressive symptoms do they experience?

  • Elisabeth Brenne (a1) (a2), Jon Håvard Loge (a1) (a3), Stein Kaasa (a1) (a2), Ellen Heitzer (a4), Anne Kari Knudsen (a1) and Elisabet Wasteson (a1) (a5)
  • DOI: http://dx.doi.org/10.1017/S1478951512000909
  • Published online: 01 February 2013
Abstract
AbstractObjective:

Diagnosing depressive disorders in palliative care is challenging because of the overlap between some depressive symptoms and cancer-related symptoms, such as loss of appetite and fatigue. In order to improve future assessment of depression in palliative care, depressive symptoms experienced by patients receiving pharmacological treatment for depression were assessed and compared to the American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) criteria for major depressive disorder.

Method:

Thirty Norwegian (n = 20) and Austrian (n = 10) patients with advanced cancer were included. Semistructured interviews on symptom experiences were conducted and transcribed verbatim. By the phenomenographic method, patients' symptom experiences were extracted and sorted by headings, first individually and then across patients. The patients subsequently rated 24 symptoms numerically including the DSM-IV depression criteria.

Results:

Lowered mood and a diminished motivational drive were prominent and reflected the two main DSM-IV symptom criteria. A relentless focus on their actual situation, restlessness, disrupted sleep, feelings of worthlessness, feelings of guilt, and thoughts of death as a solution were variably experienced. Appetite and weight changes, fatigue and psychomotor retardation were indistinguishable from cancer symptoms. All these symptoms reflected DSM-IV symptom criteria. Some major symptoms occurred that are not present in the DSM-IV symptom criteria: despair, anxiety, and social withdrawal. The numerical ratings of symptoms were mainly in accordance with the findings from the qualitative analysis.

Significance of results:

Despair, anxiety, and social withdrawal are common symptoms in depressed patients with incurable cancer, and, therefore, hypothesized as candidate symptom criteria. Other symptom criteria might need adjustment for improvement of relevance in this group of patients.

Copyright
Corresponding author
Address correspondence and reprint requests to: Elisabeth Brenne, Pain and Palliation Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 3rd Floor Gastro Centre South N-7006 Trondheim, Norway. E-mail: elisabeth.brenne@ntnu.no
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

A. Barnard , H. McCosker & R. Gerber (1999). Phenomenography: A qualitative research approach for exploring understanding in health care. Qualitative Health Research, 9, 212226.

J. Bukberg , D. Penman & J.C. Holland (1984). Depression in hospitalized cancer patients. Psychosomatic Medicine, 46, 199212.

D.M. Clarke & D.W. Kissane (2002). Demoralization: Its phenomenology and importance. Australian and New Zealand Journal of Psychiatry, 36, 733742.

P.M. Fayers , M.J. Hjermstad , A.H. Ranhoff , (2005). Which mini-mental state exam items can be used to screen for delirium and cognitive impairment? Journal of Pain and Symptom Management, 30, 4150.

K. Fearon , F. Strasser , S.D. Anker , (2011). Definition and classification of cancer cachexia: An international consensus. Lancet Oncology, 12, 489495.

J.C. Jacobsen , L.C. Vanderwerker , S.D. Block , (2006). Depression and demoralization as distinct syndromes: Preliminary data from a cohort of advanced cancer patients. Indian Journal of Palliative Care, 12, 816.

S. Johansen , J.C. Holen , S. Kaasa , (2005). Attitudes towards, and wishes for, euthanasia in advanced cancer patients at a palliative medicine unit. Palliative Medicine, 19, 454460.

S. Kaasa , J.H. Loge , P. Fayers , (2008). Symptom assessment in palliative care: a need for international collaboration. Journal of Clinical Oncology, 26, 38673873.

S. Kaasa , S. Payne & P. Sjogren (2011). Challenges related to palliative care. Lancet Oncology, 12, 925927.

A.K. Knudsen , C. Brunelli , S. Kaasa , (2011). Which variables are associated with pain intensity and treatment response in advanced cancer patients?—Implications for a future classification system for cancer pain. European Journal of Pain, 15, 320327.

A.K. Knudsen , N. Aass , E. Heitzer , (2012). Interviews with patients with advanced cancer–another step towards an international cancer pain classification system. Supportive Care in Cancer, 20, 24912500.

M. Li , P. Fitzgerald & G. Rodin (2012). Evidence-based treatment of depression in patients with cancer. Journal of Clinical Oncology, 30, 11871196.

C. Luthy , C. Cedraschi , A. Pugliesi , (2011). Patients' views about causes and preferences for the management of cancer-related fatigue–a case for non-congruence with the physicians? Supportive Care in Cancer, 19, 363370.

N. Madeira , E. Albuquerque , T. Santos , (2011). Death ideation in cancer patients: contributing factors. Journal of Psychosocial Oncology, 29, 636642.

K. Malterud (2001a). The art and science of clinical knowledge: Evidence beyond measures and numbers. The Lancet, 358, 397400.

K. Malterud (2001b). Qualitative research: Standards, challenges, and guidelines. The Lancet, 358, 483488.

F. Marton (1981). Phenomenography – Describing Conceptions of the world around us. Instructional Science, 10, 177200.

A.J. Mitchell , M. Chan , H. Bhatti , (2011). Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncology, 12, 160174.

A.J. Mitchell , K. Lord & P. Symonds (2012). Which symptoms are indicative of DSMIV depression in cancer settings? An analysis of the diagnostic significance of somatic and non-somatic symptoms. Journal of Affective Disorders, 138, 137148.

R. Nissim , L. Gagliese & G. Rodin (2009). The desire for hastened death in individuals with advanced cancer: A longitudinal qualitative study. Social Science and Medicine, 69, 165171.

M. Plumb & J. Holland (1981). Comparative studies of psychological function in patients with advanced cancer. II. Interviewer-rated current and past psychological symptoms. Psychosomatic Medicine, 43, 243254.

M.M. Plumb & J. Holland (1977). Comparative studies of psychological function in patients with advanced cancer—I. Self-reported depressive symptoms. Psychosomatic Medicine, 39, 264276.

L. Radbruch , F. Strasser , F. Elsner , (2008). Fatigue in palliative care patients — an EAPC approach. Palliative Medicine, 22, 1332.

L. Rayner , A. Price , M. Hotopf , (2011). The development of evidence-based European guidelines on the management of depression in palliative cancer care. European Journal of Cancer, 47, 702712.

G. Rodin , C. Zimmermann , A. Rydall , (2007). The desire for hastened death in patients with metastatic cancer. Journal of Pain and Symptom Management, 33, 661675.

S.C. Teunissen , W. Wesker , C. Kruitwagen , (2007). Symptom prevalence in patients with incurable cancer: A systematic review. Journal of Pain and Symptom Management, 34, 94104.

J. Walker , C.H. Hansen , I. Butcher , (2011). Thoughts of death and suicide reported by cancer patients who endorsed the “suicidal thoughts” item of the PHQ-9 during routine screening for depression. Psychosomatics, 52, 424427.

E. Wasteson , E. Brenne , I.J. Higginson , (2009). Depression assessment and classification in palliative cancer patients: a systematic literature review. Palliative Medicine, 23, 739753.

K.G. Wilson , H.M. Chochinov , M.G. Skirko , (2007). Depression and anxiety disorders in palliative cancer care. Journal of Pain and Symptom Management, 33, 118129.

M. Zimmerman , I. Chelminski , J. McGlinchey , (2006). Diagnosing major depressive disorder X. Can the utility of the DSM-IV symptom criteria be improved? Journal of Nervous and Mental Disease, 194, 893897.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Palliative & Supportive Care
  • ISSN: 1478-9515
  • EISSN: 1478-9523
  • URL: /core/journals/palliative-and-supportive-care
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: