Hostname: page-component-848d4c4894-wzw2p Total loading time: 0 Render date: 2024-05-16T14:57:50.641Z Has data issue: false hasContentIssue false
  • English
  • Français

Elemental imaging for pharmaceutical tablet formulation analysis by micro X-ray fluorescence

Published online by Cambridge University Press:  01 March 2012

Thomasin C. Miller  and
George J. Havrilla
Thomasin C. Miller*
Affiliation:
X-ray Optical Systems INC., East Greenbush, New York 12061
George J. Havrilla
Affiliation:
Chemistry Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545
*
a)Electronic mail: tmiller@xos.com
Get access Rights & Permissions [Opens in a new window]

Abstract

The analysis of the distribution of pharmaceutical materials in tablet formulations, such as drugs and matrix elements, is critical to product performance and is used in such areas as quality control, impurity testing, and process monitoring. Recently imaging techniques, such as Raman, near-IR, and fluorescence imaging, have become popular for “visualization” of pharmaceutical formulations, allowing for spatial and chemical composition information to be obtained simultaneously. These methods have been primarily focused on molecular imaging, or spatial analysis of the molecular characteristics of the tablet formulation. However, elemental species are also an important part of pharmaceuticals. Micro X-ray fluorescence (MXRF) elemental imaging offers complementary information to molecular imaging techniques. In this study, MXRF was used for the elemental imaging of various commercial pharmaceutical drug and vitamin supplements. Specifically, elemental composition and heterogeneity were monitored for each different tablet.

Type
XRF Characterization
Information
Powder Diffraction , Volume 20 , Issue 2 , June 2005 , pp. 153 - 157
Copyright
Copyright © Cambridge University Press 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Begat, P., Young, P. M., Edge, S., Kaerger, S., and Price, R. (2003). “The effect of mechanical processing on surface stability of pharmaceutical powders: Visualization by atomic force microscopy,” J. Pharm. Sci. JPMSAE 92, 611–620.CrossRefGoogle ScholarPubMed
Brittain, H. G., Bogdanowich, S. J., Bugay, D. E., De Vincentis, J., Lewen, G., and Newman, A. W. (1991). “Physical characterization of pharmaceutical solids,” Pharm. Res. PHREEB 8, 963–973.CrossRefGoogle ScholarPubMed
Butkus, B. D. (2003). “Diamond improves optical analysis of pharmaceutical tablets,” Biophotonics International, 2003, pp. 19–20.Google Scholar
Chan, K. L. A., Hammond, S. V., and Kazarian, S. G. (2003). “Applications of attenuated total reflection infrared spectroscopic imaging to pharmaceutical formulations,” Anal. Chem. ANCHAM 75, 2140–2146.CrossRefGoogle ScholarPubMed
Clarke, F. C., Jamieson, M. J., Clark, D. A., Hammond, S. V., Jee, R. D., and Moffat, A. C. (2001). “Chemical image fusion. The synergy of FT-NIR and Raman mapping microscopy to enable a more complete visualization of pharmaceutical formulations,” Anal. Chem. ANCHAM 73, 2213–2220.CrossRefGoogle ScholarPubMed
Higgins, J. D. III, and Rocco, W. L. (2003). “Pharma preformulation,” Today's Chemist at Work 12, 22–26.Google Scholar
Kotula, P. G., Keenan, M. R., and Michael, J. R. (2003). “Automated analysis of SEM X-ray spectral images: A powerful new microanalysis tool,” Microsc. Microanal. MIMIF7 10.1017/S1431927603030058 9, 1–17.CrossRefGoogle ScholarPubMed
Mouget, Y., Gosselin, P., Tourigny, M., and Bechard, S. R. (2003). “Three-dimensional analyses of tablet content and film coating uniformity by laser-induced breakdown spectroscopy (LIBS),” Am. Lab. (Shelton, Conn.) ALBYBL 35, 20–22.Google Scholar
Schaeberle, M. D., Morris, H. R., Turner, J. F. II, and Treado, P. J. (1999). “Raman chemical imaging spectroscopy,” Anal. Chem. ANCHAM 71, 175A–181A.CrossRefGoogle ScholarPubMed
Wagner, M., Rostam-Khani, P., Wittershagen, A., Rittmeyer, C., Kolbesen, B. O., and Hoffman, H. (1997). “Trace element determination in drugs by total-reflection X-ray fluorescence spectrometery,” Spectrochim. Acta, Part B SAASBH , 52, 961–965.CrossRefGoogle Scholar