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Single-crystal structure analysis of designer drugs circulating in the Japanese drug market by the synchrotron radiation X-ray diffraction

  • Takashi Hashimoto (a1) (a2), Ruri Hanajiri (a3), Nobuhiro Yasuda (a1), Yuki Nakamura (a1), Nobuhiro Mizuno (a1), Sadao Honda (a1), Shinjiro Hayakawa (a1) (a4), Yoshinori Nishiwaki (a1) (a5) and Shigeru Kimura (a1)...
Abstract

Over the past 20 years, many designer drugs derived from controlled substances have been widely distributed as easily available psychoactive substances and have become a serious problem in Japan. In order to determine the absolute structures of four new designer drugs derived from medicines (methylphenidate and phenmetrazine) X-ray single-crystal structure analyses were performed using the BL26B1 beamline of synchrotron radiation facility SPring-8. The results show that the molecular configuration of these designer drugs (having two asymmetric carbons), which were distributed in the illegal drug market had threo-forms as found for methylphenidate and phenmetrazine.

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a)Author to whom correspondence should be addressed. Electronic mail: thashimoto@spring8.or.jp
References
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Hashimoto T., Honda S., Yasuda N., Kimura S., Hayakawa S., Nishiwaki Y., and Takata M. (2015) “Single-crystal structure analysis of drug powder sample by synchrotron radiation microbeam X-ray,” Adv. X-ray Anal. 59, 169.
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Ueno G., Kanda H., Hirose R., Ida K., Kumasaka T., and Yamamoto M. (2006) “RIKEN structural genomics beamlines at the SPring-8; high throughput protein crystallography with automated beamline operation,” J. Struct. Funct. Genomics 7, 15.
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Powder Diffraction
  • ISSN: 0885-7156
  • EISSN: 1945-7413
  • URL: /core/journals/powder-diffraction
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