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Bayesian segregation analysis of osteochondral diseases in pigs to determine major gene role

Published online by Cambridge University Press:  23 November 2017

H. N. Kadarmideen  and
L.L. G. Janss
H. N. Kadarmideen*
Affiliation:
Institute of Animal Sciences, Statistical Animal Genetics Group, Swiss Federal Institute of Technology, ETH-Zentrum (UNS D), CH-8092 Zurich, Switzerland
L.L. G. Janss
Affiliation:
Animal Sciences Group, Wageningen University and Research Centre, PO. Box 65, 8200 AB Lelystad, The Netherlands
*
Email: haja.kadarmideen@inw.agrl.ethz.ch
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Extract

Osteochondrosis (OC) in pigs is an abnormal condition in the bone development which has high economic and welfare implications. Select for OC resistance would be difficult to achieve due to low polygenic heritability (∼0.06 – 0.15; Kadarmideen et al., 2004), unless a major gene exists. Segregation analysis provides evidence for major gene using only phenotypic data. Bayesian Segregation Analysis (BSA) method via Gibbs sampling is suitable for pedigreed animal population as shown in the application of this methodology to milk flow in dairy cattle (Ilahi and Kadarmideen, 2004). The main objective of this study was to conduct a BSA to determine whether osteochondral disease in pigs has mixed inheritance (major + polygenes).

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2005 , 2005 , pp. 51
Copyright
Copyright © The British Society of Animal Science 2005

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References

Janss, L. L. G., Thompson, R., and van Arendonk, J. A. M. 1995. Application of Gibbs sampling for inference in a mixed major gene-polygenic inheritance model in animal populations, Theor. Appl. Genet. 91 1137–1147.CrossRefGoogle Scholar
Kadarmideen, H. N., Schwörer, D., Ilahi, H., Malek, M. and Hofer, A. 2004. Genetics of osteochondral disease and its relationship with meat quality and quantity, growth and feed conversion traits in pigs. J. Anim. Sci. 82: 3118–3127.CrossRefGoogle ScholarPubMed
Ilahi, H. and Kadarmideen, H. N. 2004. Bayesian segregation analysis of milk flow in Swiss dairy cattle using Gibbs sampling. Genet. Sel. Evol. 36: 563–576.CrossRefGoogle ScholarPubMed