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We performed 3D N-body/hydrodynamic simulations of local and high-z (z ∼ 2) star-forming galaxies (SFGs) to investigate the structure and kinematic properties of the different ISM phases (i.e., ionized, atomic, and molecular gases). We took into account, for the first time, a fully non-equilibrium radiative cooling by solving the non-equilibrium chemistries of atoms (H, He, C and O) and molecules (H2 and CO), as well as radiative heating, star formation, heating by HII region and supernova explosions.
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