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Choice of neuroleptics in epilepsy

  • Harry McConnell (a1), Denise Duncan (a2) and David Taylor (a2)
Extract

The decision to use a neuroleptic in people with epilepsy (PWE) depends on the nature of the psychosis being treated. In some cases a neuroleptic is not required and an adjustment of the antiepileptic drug therapy may be all that is necessary. Antiepileptic drug therapy itself can cause psychosis and this, as well as other aetiologies, should be considered. The choice of neuroleptic in PWE depends on: the nature of the patient's psychosis, including the temporal relationship with seizures and/or any relationship to antiepileptic drug therapy; the epileptogenicity of the neuroleptic; antiepileptic drugs; the efficacy of the neuroleptic; and individual tolerability of side-effects.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
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References
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Arana, G. W., Goff, D. C., Friedman, H., et al (1986) Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms? American Journal of Psychiatry, 143, 650651
Fast, D. K., Jones, B. D., Kusalic, M., et al (1986) Effect of carbamazepine on neuroleptic plasma levels and efficacy. American Journal of Psychiatry, 143, 117118.
Fenwick, P. (1995) Psychiatric disorder and epilepsy. In Epilepsy (eds Hopkins, A., Shorvon, S. & Cascino, G.), pp. 453502. London: Chapman and Hall Medical.
Itil, T. M. & Soldatos, C. (1980) Epileptogenic side effects of psychotropic drugs. Journal of the American Medical Association, 244, 14601463.
Izmeth, M., Khan, S., Kumarajeewa, D., et al (1988) Zuclopenthixol decanoate in the management of behavioural disorders in mentally handicapped patients. Pharmatherapeutica, 5, 217227.
Keepers, G. A. (1990) Neuroleptic malignant syndrome associated with withdrawal from carbamazepine (letter). American Journal of Psychiatry, 147, 12.
Ketter, T. A., Post, R. M. & Worthington, K. (1991) Principles of clinically important drug interactions with carbamazepine, part II. Journal of Clinical Psychopharmacology, 11, 306312.
Larkin, C. (1983) Epileptogenic effect of pimozide. American Journal of Psychiatry, 140, 372373.
Logothetis, J. (1967) Spontaneous epileptic seizures and EEG changes in the course of phenothiazine therapy. Neurology, 17, 869877.
Markowitz, J. C. & Brown, R. P. (1987) Seizures with neuroleptics and antidepressants. General Hospital Psychiatry, 9, 135141.
Marks, R. C. & Luchins, D. L. (1991) Antipsychotic medications and seizures. Psychiatric Medicine, 9, 3752.
McConnell, H. W. & Duncan, D. A. (1997) The treatment of psychiatric co-morbidity in epilepsy. In Epilepsy and Psychiatric Co-Morbidity: Basic Mechanisms, Diagnosis and Treatment (eds McConnell, H. W. & Snyder, P. J.), in press. Washington. DC: American Psychiatric Press.
Miller, D. D. (1991) Effect of phenytoin on plasma clozapine concentrations in two patients. Journal of Clinical Psychiatry, 52, 2325.
Oliver, A. P., Luchins, D. J. & Wyatt, R. J. (1982) Neuroleptic-induced seizures. Archives of General Psychiatry, 39, 206209.
Pacia, S. V. & Devinsky, O. (1994) Clozapine-related seizures. Neurology, 44, 22472249.
Remick, R. & Fine, S. (1979) Antipsychotic drugs and seizures. Journal of Clinical Psychiatry, 40, 7880.
Satoh, H., Nakanishi, H., Shirakawa, K., et al (1987) Comparative study of tiapride and neuroleptics with anti-dopamine activity on convulsive seizure in mice. Japan Journal of Pharmacology, 43, 2732.
Tiihonen, J., Vartiainen, H. & Hakola, P. (1995) Carbamazapine induced changes in plasma levels of neuroleptics. Pharmacopsychiatry, 28, 2628.
Toone, B. K. & Fenton, G. W. (1977) Epileptic seizures induced by psychotropic drugs. Psychological Medicine, 7, 265270.
Toth, P. & Frankenburg, F. R. (1994) Clozapine and seizures–a review. Canadian Journal of Psychiatry, 39, 236238.
Trimble, M. R. (1985) The psychoses of epilepsy and their treatment. In The Psychopharmacology of Epilepsy, (ed. Trimble, M. R.), pp. 8394. Chichester: John Wiley and Sons.
Trimble, M. R. (1991) Treatment of epileptic psychosis. In The Psychosis of Epilepsy, (ed. Trimble, M. R.), pp. 150165. New York: Raven Press.
Whitworth, A. B. & Fleischhacker, W. W. (1995) Adverse effects of antipsychotic drugs. International Clinical Psychopharmacology, 9 (suppl. 5). 2127.
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BJPsych Bulletin
  • ISSN: 0955-6036
  • EISSN: 1472-1473
  • URL: /core/journals/bjpsych-bulletin
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Choice of neuroleptics in epilepsy

  • Harry McConnell (a1), Denise Duncan (a2) and David Taylor (a2)
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