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Continuation of clozapine treatment: practice makes perfect

  • Eromona Whiskey (a1), Til Wykes (a2), Denise Duncan-McConnell (a1), Elke Haworth (a3), Nick Walsh (a4) and Sarah Hastilow (a4)...
Abstract
Aims and Method

The study aimed to identify the predictors of drop-out from clozapine treatment by examining the demographic and clinical characteristics of patients registered on clozapine within a 6-month period in one NHS Trust.

Results

During the study period, 54 patients were registered and began clozapine treatment and 31% had discontinued within 6 months. Two people died and the remainder discontinued because of non-compliance or side-effects, including neutropenia. Two factors were predictive: the age of the patient (older patients were more likely to discontinue) and the hospital where the initial registration was made.

Clinical Implications

Neither ethnicity, previous registration nor the individual prescriber are a bar to successful persistence with clozapine. However, one set of hospitals with a history of evidence-based practice and high clozapine prescribing was more successful in retaining patients on maintenance treatment. Although specific data are needed to identify more subtle contributing factors to continuation, it is clear that there is scope for improving the rate of persistence with clozapine treatment.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
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BJPsych Bulletin
  • ISSN: 0955-6036
  • EISSN: 1472-1473
  • URL: /core/journals/bjpsych-bulletin
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Continuation of clozapine treatment: practice makes perfect

  • Eromona Whiskey (a1), Til Wykes (a2), Denise Duncan-McConnell (a1), Elke Haworth (a3), Nick Walsh (a4) and Sarah Hastilow (a4)...
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