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The impact of olanzapine on attitude to medication and quality of life in schizophrenia

  • James Stallard (a1) and Eileen Joyce (a2)
Abstract
AIMS and Method

This study aimed to compare the subjective quality of life and attitudes to medication between groups of patients with schizophrenia taking either olanzapine or traditional antipsychotic medication.

Results

The two groups were matched for age, gender, length of illness and antipsychotic group demonstrated more extrapyramidal side-effects (EPS) and akathisia. Within this group, those with EPS scored lower on the affect balance scale of the Lancashire Quality of Life Scale than those without. More patients in the olanzapine group reported that medication was taken to prevent symptoms returning.

Clinical Implications

These results lend support to the hypothesis that the presence of EPS impairs quality of life and suggest that olanzapine therapy may improve patients' attitudes to medication.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
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Barnes, T. R. E. (1989) A rating scale for drug-induced akathisia. British Journal of Psychiatry, 154, 672676.
Beasley, C., Sanger, T., Satterlee, W., et al (1996a) Results of a double-blind fixed-dose olanzapine trial. Psychopharmacology 124, 159167.
Beasley, C., Tollefson, G., Tran, P., et al (1996b) Olanzapine versus haloperidol and placebo: acute phase results of North American olanzapine trial. Neuropsychopharmacology, 14, 111124.
Beasley, C., Hamilton, S., Crawford, A., et al (1997) Olanzapine versus haloperidol: acute phase results of the international double-blind olanzapine trial. European Neuropsychopharmacology, 7, 125137.
Guy, W. (1976) ECDEU Assessment Manual for Psychophamarcology Revised DHEW Pub (ADM). Rockville, MD: National Institute of Mental Health.
Kane, J. (1989) The current status of neuroleptics. Journal of Clinical Psychiatry, 50, 322328.
Kane, J., Honingfield, G., Singer, J., et al (1988) Clozapine in treatment resistant schizophrenia: a double-blind comparison with chlorpromazine. Archives of General Psychiatry, 45, 789796.
Oliver, J. (1991) The social care directive: development of a quality of life profile for use in community services for the mentally ill. Social Work and Social Sciences Review, 3, 545.
Overall, J. & Gorham, D. (1962) The Brief Psychiatric Rating Scale. Psychological Reports, 10, 799812.
Simpson, G. & Angus, J. (1970) A Rating Scale for Extrapyramidal Symptoms. Acta Psychologica Scandinavica, 212, 511519.
Tollefson, G., Beasley, C., Tran, P., et al (1997) Olanzapine versus haloperidol in the treatment of schizophrenia, schizoaffective and schizophreniform disorders: results of an international collaborative trial. American Journal of Psychiatry, 154, 466474.
Weiden, P. (1991) Neuroleptic noncompliance in schizophrenia. In: Advances in Neuropsychiatry and Psychopharmacology: Schizophrenia Research (eds Tamminga, C. & Schultz, S.), pp. 285299. NewYork: Raven Press.
Weiden, P., Rapkin, B., Matt, T., et al (1994) Rating of Medication Influences (ROMI) Scale in schizophrenia. Schizophrenia Bulletin, 20, 297310.
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BJPsych Bulletin
  • ISSN: 0955-6036
  • EISSN: 1472-1473
  • URL: /core/journals/bjpsych-bulletin
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The impact of olanzapine on attitude to medication and quality of life in schizophrenia

  • James Stallard (a1) and Eileen Joyce (a2)
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