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The influence of patient variables on polypharmacy and combined high dose of antipsychotic drugs prescribed for in-patients

  • Paul Lelliott (a1), Carol Paton (a2), Maria Harrington (a3), Maria Konsolaki (a3), Tom Sensky (a4) and Chike Okocha (a5)...
Abstract
Aims and Method

A1-day census, involving 3576 psychiatric in-patients prescribed antipsychotic medication, was conducted as a prelude to a multi-centre audit. The aim was to explore the extent to which a number of patient variables explain antipsychotic polypharmacy and the use of high doses of these drugs.

Results

Prescriptions of more than one type of antipsychotic drug were made for 50.5% of patients. Patient factors that influenced the probability of polypharmacy were: younger age, being male, detained under the Mental Health Act and on a rehabilitation or forensic ward, and a diagnosis of schizophrenia. The effect of ethnicity was not significant. Polypharmacy was the most powerful factor influencing the probability of being prescribed a high dose. Identified patient variables accounted for only 18% of the variance in dose prescribed.

Clinical Implications

The patient and clinician factors that account for the unexplained variance need to be identified.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
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BJPsych Bulletin
  • ISSN: 0955-6036
  • EISSN: 1472-1473
  • URL: /core/journals/bjpsych-bulletin
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The influence of patient variables on polypharmacy and combined high dose of antipsychotic drugs prescribed for in-patients

  • Paul Lelliott (a1), Carol Paton (a2), Maria Harrington (a3), Maria Konsolaki (a3), Tom Sensky (a4) and Chike Okocha (a5)...
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