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National differences in disulfiram prescribing

  • Jonathan Chick (a1) and Colin Brewer (a2)
Abstract
Aims and method

To test the impression of wide national differences in the use of deterrent medication in the treatment of alcohol dependence, data showing comparative sales of disulfiram in 13 countries were obtained.

Results

Sales in Britain were lowest, and less than a tenth of those in Denmark. Rates bore no relation to alcohol sales or an index of alcohol-related problems in the 13 countries.

Clinical implications

British doctors may apply a particularly cautious risk/benefit ratio for disulfiram. The disparity may also reflect the predominantly nonmedical approach to treating alcohol dependence in Britain.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
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References
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Alcoholics Anonymous (1975) Living Sober. Pp. 60. London: Jupiter.
Amador, E. & Gazdar, A. (1967) Sudden death during disulfiram alcohol reaction. Quarterly Journal of Studies on Alcohol, 28, 649 654.
Becker, M. & Sugarman, G. (1952) Death following ‘test drink’ of alcohol in patients receiving Antabuse. Journal of the American Medical Association, 149, 568 571.
Besson, J., Aeby, F., Kasas, A., et al (1998) Combined efficacy of acamprosate and disulfiram in the treatment of alcoholism: a controlled study. Alcohol and Alcoholism, 22, 573 579.
Black, J. & Richardson, J. (1985) Disulfiram hepatotoxicity: case report. Journal of Clinical Psychiatry, 46, 67 68.
Branchey, L., Davis, W., Lee, K. K., et al (1987) Psychiatric complications of disulfiram treatment. American Journal of Psychiatry, 144, 1310 1312.
Brewer, C. (1984) How effective is the standard dose of disulfiram? A review of the alcohol–disulfiram reaction in practice. British Journal of Psychiatry, 144, 200 202.
Brewer, C. (1993) Invited review: recent developments in disulfiram treatment. Alcohol & Alcoholism, 28, 383 395.
Brewer, C. (1996) On the specific effectiveness, and under-valuing, of pharmacological treatments for addiction: a comparison of methadone, naltrexone and disulfiram with psychosocial interventions. Addiction Research, 3, 297 313.
British National Formulary (1997) British National Formulary. London: British Medical Association and Royal Pharmaceutical Society of Great Britain.
Caplehorn, J. R. M. (1995) Methadone maintenance treatment: Britain has been over-committed to psychological theories of drug dependence. British Medical Journal, 310, 465.
Carroll, K., Ziedonis, D., O'Malley, S., et al (1993) Pharmacological interventions for alcohol- and cocaine-abusing individuals: A pilot study of disulfiram vs. naltrexone. American Journal on Addictions, 2, 77 79.
Chan, K. Y. (1996) The Singapore naltrexone community-based project for heroin addicts compared with a drug-free community-based programme: the first cohort. Journal of Clinical Forensic Medicine, 3, 87 92.
Chick, J. (1996) Medication in the treatment of alcohol dependence. Advances in Psychiatric Treatment, 2, 249 257.
Chick, J., Gough, K., Falkowski, W., et al (1992) Disulfiram treatment of alcoholism. British Journal of Psychiatry, 161, 84 89.
Davies, J. B. (1992) The Myth of Addiction – An Application of the Psychological Theory of Attribution of Illicit Drug Use. Chan Harwood Academic Press.
Department of Health Working Party on Alcohol Misuse (1989) Drinking Problems – A Challenge for Every Doctor. London: Department of Health.
Dilts, S. & Dilts, S. (1996) Assessing liver function before initiating disulfiram therapy. American Journal of Psychiatry, 153, 1504 1505.
Edwards, G. (1987) The Treatment of Drinking Problems: A Guide for the Helping Professions (2nd edn). Oxford: Blackwell.
Edwards, G., Marshall, J., Cook, C. C. (1997) The Treatment of Drinking Problems. (3rd edn). London: Cambridge University Press.
Forns, X., Caballeria, J., Bruguera, M., et al (1994) Disulfiram-induced hepatitis. Report of four cases and review of the literature. Journal of Hepatology, 21, 853 857.
Fuller, R. K., Branchey, L., Brightwell, D. R., et al (1986) Disulfiram treatment of alcoholism. Journal of the American Medical Society, 256, 1449 1455.
Glass, I. (ed.) (1991) International Handbook on Addictive Behaviour. London: Routledge.
Goyer, P. & Major, L. (1979) Hepatotoxicity in disulfiram-treated patients. Journal of Studies on Alcohol, 2, 133 137.
Guarnaschelli, J., Zapanta, E. & PITTS, G. (1972) Intracranial haemorrhage associated with the disulfiram-alcohol reaction. Bulletin of the Los Angeles Neurological Society, 37, 19 23.
Heather, N. (1989) Disulfiram treatment in alcoholism: deserves a second chance? British Medical Journal, 299, 471 472.
Heather, N. (1993) Disulfiram treatment for alcohol problems: is it effective, and if so. why? In Treatment Options in Addiction: Medical Management of Alcohol and Opiate Abuse (ed. Brewer, C.), pp. 1 18. London: Gaskell.
Heather, N. & Robertson, I. (1981) Controlled Drinking. London: Methuen.
Hughes, J. C. & Cook, C. (1997) The efficacy of disulfiram – a review of outcome studies. Addiction, 92, 381 396.
Iber, F. L., Lee, K., Lacoursiere, R., et al (1987) Liver toxicity encountered in the Veterans Administration trial of disulfiram in alcoholics. Alcoholism: Clinical and Experimental Research, 11, 301 304.
Kaaber, K., Menne, T., Veien, N., et al (1987) Some adverse effects of disulfiram in the treatment of nickel-allergic patients. Dermatosen Beruf Umwelt, 38, 211.
O'Brien, C. P., Volpicelli, L. A. & Volpicelli, J. R. (1996) Naltrexone in the treatment of alcoholism: a clinical review. Alcohol, 13, 35 39.
Pouch, J. M., Armor, D. & Braiker, H. (1981) The Course of Alcoholism Four Years After Treatment. New York: John Wiley and Sons.
Poulsen, E. H., Loft, S., Andersen, J. R., et al (1992) Disulfiram therapy adverse drug reaction and interactions. Acta Psychiatrica Scandinavida, 86, 59 66.
Shaw, S. (1985) The disease concept of dependence. In The Misuse of Alcohol Crucial Issues on Dependence. Treatment and Prevention (eds Heather, N., Robertson, I. & Davies, P.). London: Croom Helm.
Sunderman, F. W. (1958) Dithiocarb: a new therapeutic agent for persons exposed to nickel carbonyl. American Journal of Medical Science, 236, 26 30.
Volpicelli, J. R., Rhines, K. C., Rhines, J. S., et al (1997) Naltrexone and alcohol dependence. Archives of General Psychiatry, 54, 1737 1742.
World Drink Trends (1992) World Drink Trends. International Beverage Alcohol Consumption and Production Trends. Henley-on-Thames: Produktschap voor Gedistillerde Dranken and NTC Publications.
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BJPsych Bulletin
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National differences in disulfiram prescribing

  • Jonathan Chick (a1) and Colin Brewer (a2)
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