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Pramipexole in unipolar and bipolar depression

  • Eromona Whiskey (a1) and David Taylor (a2)
Abstract
Aims and Method

To review the evidence for this use of pramipexole in the treatment of unipolar and bipolar depression, a literature search on Embase and Medline was conducted in December 2003. The search was updated in July 2004. The reference sections of retrieved papers were searched for further relevant references.

Results

There are limited data on the clinical use of pramipexole in affective disorders. Only two double-blind trials in bipolar depression and one in unipolar depression were retrieved. Most information is in the form of case reports and open studies. No dose-response relationships have been established and a wide range of doses has been employed in the reports.

Clinical Implications

In view of the fact that the evidence for the use of pramipexole is still limited at the time of writing, its routine clinical use cannot be recommended. The data appear promising, but further research is required to determine its role in affective disorders.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
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Corrigan, M., Denahan, A., Eugene Wright, C., et al (2000) Comparison of pramipexole, fluoxetine and placebo in patients with major depression. Depression and Anxiety, 11, 5865.
Debattista, C., Solvason, H., Breer, I., et al (2000) Pramipexole augmentation of a selective serotonin reuptake inhibitor in the treatment of depression. Journal of Clinical Psychopharmacology, 20, 274275.
Goldberg, J., Frye, M. & Dunn, R. (1999) Pramipexole in refractory bipolar depression. American Journal of Psychiatry 156, 798799.
Goldberg, F., Burdick, K. E., Endick, C. J. (2004) Preliminary randomised, double-blind placebo-controlled trial of pramipexole added to mood stabilisers for treatment-resistant bipolar depression. American Journal of Psychiatry, 161, 564566.
Lattanz, I., Dell'Osso, L., Cassano, P., et al (2002) Pramipexole in treatment-resistant depression: a 16-week naturalistic study. Bipolar Disorders, 4, 307314.
Maj, J. & Rogoz, Z. (1999) Synergistic effect of pramipexole and sertraline in the forced swimming test. Polish Journal of Pharmacology, 51, 471475.
Ostow, M. (2002) Pramipexole for depression. American Journal of Psychiatry, 159, 320321.
Perugi, G., Toni, C., Ruffolo, G., et al (2001) Adjunctive dopamine agonists in treatment-resistant bipolar II depression: an open case series. Pharmacopsychiatry, 34, 137141.
Rampello, L., Nicoletti, F. & Nicoletti, F. (2000) Dopamine and depression: Therapeutic implications. CNS Drugs, 13, 3545.
Rektorová, I. Rektor, I., Barešm, ., et al (2003) Pramipexole and pergolide in the treatment of depression in Parkinson's disease: a national multicentre prospective randomised study. European Journal of Neurology, 10, 399406.
Renard, C., Fiocco, A., Clenet, F. et al (2001) Is dopamine implicated in the antidepressant-like effects of SSRIs in the mouse forced swimming test? Psychopharmacology 159, 4250.
Silverstone, T. (1984) Response to bromocriptine distinguishes bipolar from unipolar depression. Lancet, 1, 903904.
Sporr, J., Ghaem, N. G., Sambur, M. R., et al (2000) Pramipexole augmentation in the treatment of unipolar and bipolar depression. A retrospective chart review. Annals of Clinical Psychiatry, 12, 137140.
Szegedi, A., Hillert, A., Wetzel, H., et al (1997) Pramipexole, a dopamine agonist, in major depression: Antidepressant effects and tolerability in an open-label study with multiple doses. Clinical Neuroparmacol, 20, S36S45.
Willner, P. (1983) Dopamine and depression: a review of recent evidence. Brain Res Rev, 6, 211246.
Willner, P. (1995) Dopaminergic mechanisms in depression and mania. In Psychopharmacology: thefourth generation of progress (eds Bloom, F. & Kupfer, D.), pp. 921932. New York: Raven Press.
Zarate, C. A. Jr, Payne, J. L., Singh, J. et al (2004) Pramipexole for bipolar II depression: A placebo-controlled proof of concept study. Biologicakl Psychiatry, 56, 5460.
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BJPsych Bulletin
  • ISSN: 0955-6036
  • EISSN: 1472-1473
  • URL: /core/journals/bjpsych-bulletin
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Pramipexole in unipolar and bipolar depression

  • Eromona Whiskey (a1) and David Taylor (a2)
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