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Which is the safest antidepressant to use in epilepsy?

  • Denise Duncan and David Taylor (a1)
Extract

Seizures are a serious adverse effect of many antidepressants: most, if not all, tricyclics (TCAs) lower the seizure threshold, some atypicals (e.g. maprotiline) are known to cause convulsions and seizures have been reported to occur with all selective serotonin reuptake inhibitors (SSRIs). Opinions vary on which is the safest antidepressant to use in epilepsy.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
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Frommer, D. A., Kulig, K. W., Marx, J. A. et al (1987) Tricyclic antidepressant overdose: a review. Journal of American Medical Association, 257, 521526.
Jabbari, B., Bryan, G. E., Marsh, E. E. & Gunderson, C. H. (1985) Incidence of seizures with tricyclic and tetracyclic antidepressants. Archives of Neurology, 42, 480481.
Peck, A. W., Stern, W. C. & Watkinson, C. (1983) Incidence of seizures during treatment with tricyclic antidepressant drugs and bupropion. Journal of Clinical Psychiatry, 44, 197201.
Physician's Desk Reference (1992) Prozac. Montvale, NJ: Medical Economics, P. 921.
Rosenstein, D. L., Nelson, J. C. & Jacobs, S. C. (1993) Seizures associated with antidepressants: a review. Journal of Clinical Psychiatry, 54, 89299.
Showron, D. M. & Stimmel, G. L. (1992) Antidepressants and the risk of seizures. Pharmcotherapy, 12, 1822.
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Wedin, G. P., Oderda, G. M., Klein-Schwartz, W. et al (1986) Relative toxicity of cyclic antidepressants. Annals of Emergency Medicine, 15, 797804.
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BJPsych Bulletin
  • ISSN: 0955-6036
  • EISSN: 1472-1473
  • URL: /core/journals/bjpsych-bulletin
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Which is the safest antidepressant to use in epilepsy?

  • Denise Duncan and David Taylor (a1)
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