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Working with clozapine

  • Clive Adams and M. Adib Essali (a1)
Extract

Clozapine is an atypical antipsychotic drug with relatively weak D2 and D1 blocking properties and strong 5HT and cholinergic blockade. Its potency as an antipsychotic drug is surprising considering the ratio of receptor blockade and it represents a true advance in treatment of schizophrenia. The efficacy of clozapine calls for revision of the seemingly over simplistic dopamine theory of schizophrenia. Now clozapine is available in the UK to consultant psychiatrists who register with the Clozaril Patient Monitoring Service (CPMS).

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
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Adams, C., Riccio, M., McCarthy, D., Barnes, T. R. E. & Hirsch, S. R. H. (1990) Agranulocytosis induced by clozapine with the early addition of trifluoperazine: a case report. International Clinical Psychopharmacology, 5, 287291.
Chouinard, G., Jones, B. D. & Annable, L. (1978) Neuroleptic induced supersensitivity psychosis. American Journal of Psychiatry, 135, 14091410.
Kane, J., Hongfeld, G., Singer, J. & Meltzer, H. (1988) Clozapine for treatment-resistant schizophrenia: a double blind comparison with chloropromazine. Archives of General Psychiatry, 45, 789796.
Meltzer, H. Y. (1989) The follow up of clozapine treated treatment-resistant schizophrenics at six months. Archives of General Psychiatry, 46, 672675.
Westermyer, J. F. & Harrow, M. (1990) Prognosis and natural course of schizophrenia. Current Opinion in Psychiatry, 3, 37.
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BJPsych Bulletin
  • ISSN: 0955-6036
  • EISSN: 1472-1473
  • URL: /core/journals/bjpsych-bulletin
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Working with clozapine

  • Clive Adams and M. Adib Essali (a1)
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