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Accumulation of trauma over time and risk for depression in a twin sample

  • V. V. McCutcheon (a1), A. C. Heath (a1), E. C. Nelson (a1), K. K. Bucholz (a1), P. A. F. Madden (a1) and N. G. Martin (a2)...
Abstract
Background

Few genetically informative studies have examined the effects of different types of trauma on risk for depression over time. The aim of the present study was to examine the relative contributions over time of assaultive trauma, non-assaultive trauma, and familial effects to risk for depression.

Method

Histories of depression and trauma were obtained during structured diagnostic interviews with 5266 (mean age 29.9 years, s.d.=2.4) members of a volunteer Australian twin panel from the general population. Age at first onset of a DSM-IV major depressive episode was the dependent variable. Associations of depression with traumatic events were examined while accounting for the temporal sequence of trauma and depression and familial effects.

Results

Assaultive traumatic events that occurred during childhood had the strongest association with immediate and long-term risk for depression, and outweighed familial effects on childhood-onset depression for most twins. Although men and women endorsed equal rates of assaultive trauma, women reported a greater accumulation of assaultive events at earlier ages than men, whereas men reported a greater accumulation of non-assaultive events at all ages.

Conclusions

Early exposure to assaultive trauma can influence risk for depression into adulthood. Concordance for early trauma is a significant contributor to the familiality of early-onset depression.

Copyright
Corresponding author
*Address for correspondence: V. V. McCutcheon, Ph.D., Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave., Campus Box 8134, St Louis, MO 63110, USA. (Email: vmccutcheon@wustl.edu)
References
Hide All
APA (1994). Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R), 3rd edn, revised. American Psychiatric Association: Washington, DC.
Aziz MA, Kenford S (2004). Comparability of telephone and face-to-face interviews in assessing patients with posttraumatic stress disorder. Journal of Psychiatric Practice 10, 307313.
Breslau N, Chilcoat HD, Kessler RC, Davis GC (1999). Previous exposure to trauma and PTSD effects of subsequent trauma: results from the Detroit Area Survey of Trauma. American Journal of Psychiatry 156, 902907.
Breslau N, Davis GC, Andreski P, Peterson E (1991). Traumatic events and posttraumatic stress disorder in an urban population of young adults. Archives of General Psychiatry 48, 216222.
Breslau N, Kessler RC, Chilcoat HD, Schultz LR, Davis GC, Andreski P (1998). Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma. Archives of General Psychiatry 55, 626632.
Breslau N, Peterson EL, Schultz LR (2008). A second look at prior trauma and the posttraumatic stress disorder effects of subsequent trauma: a prospective epidemiological study. Archives of General Psychiatry 65, 431437.
Breslau N, Wilcox HC, Storr CL, Lucia VC, Anthony JC (2004). Trauma exposure and posttraumatic stress disorder: a study of youths in urban America. Journal of Urban Health 81, 530544.
Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI Jr., Reich T, Schmidt I, Schuckit MA (1994). A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. Journal of Studies on Alcohol 55, 149158.
Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386389.
Cleves MA, Gould WW, Gutierrez RG (2004). An Introduction to Survival Analysis Using Stata, revised edn. College Station, TX: Stata Press.
Copeland WE, Keeler G, Angold A, Costello EJ (2007). Traumatic events and posttraumatic stress in childhood. Archives of General Psychiatry 64, 577584.
Cottler LB, Robins LN, Helzer JE (1989). The reliability of the CIDI-SAM: a comprehensive substance abuse interview. British Journal of Addiction 84, 810814.
Creamer M, Burgess P, McFarlane AC (2001). Post-traumatic stress disorder: findings from the Australian National Survey of Mental Health and Well-being. Psychological Medicine 31, 12371247.
De Bellis MD, Keshavan MS (2003). Sex differences in brain maturation in maltreatment-related pediatric posttraumatic stress disorder. Neuroscience and Biobehavioral Reviews 27, 103117.
De Bellis MD, Keshavan MS, Shifflett H, Iyengar S, Beers SR, Hall J, Moritz G (2002). Brain structures in pediatric maltreatment-related posttraumatic stress disorder: a sociodemographically matched study. Biological Psychiatry 52, 10661078.
De Bellis MD, Kuchibhatla M (2006). Cerebellar volumes in pediatric maltreatment-related posttraumatic stress disorder. Biological Psychiatry 60, 697703.
Dinwiddie S, Heath AC, Dunne MP, Bucholz KK, Madden PA, Slutske WS, Bierut LJ, Statham DB, Martin NG (2000). Early sexual abuse and lifetime psychopathology: a co-twin-control study. Psychological Medicine 30, 4152.
Dong M, Anda RF, Felitti VJ, Dube SR, Williamson DF, Thompson TJ, Loo CM, Giles WH (2004). The interrelatedness of multiple forms of childhood abuse, neglect, and household dysfunction. Child Abuse and Neglect 28, 771784.
Dube SR, Felitti VJ, Dong M, Giles WH, Anda RF (2003). The impact of adverse childhood experiences on health problems: evidence from four birth cohorts dating back to 1900. Preventive Medicine 37, 268277.
Eley TC, Sugden K, Corsico A, Gregory AM, Sham P, McGuffin P, Plomin R, Craig IW (2004). Gene–environment interaction analysis of serotonin system markers with adolescent depression. Molecular Psychiatry 9, 908915.
Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, Koss MP, Marks JS (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine 14, 245258.
Fergusson DM, Horwood LJ, Lynskey MT (1996). Childhood sexual abuse and psychiatric disorder in young adulthood. II. Psychiatric outcomes of childhood sexual abuse. Journal of the American Academy of Child and Adolescent Psychiatry 35, 13651374.
Grambsch PM, Therneau TM (1994). Proportional hazards tests in diagnostics based on weighted residuals. Biometrika 81, 515526.
Heath AC, Bucholz KK, Madden PA, Dinwiddie SH, Slutske WS, Bierut LJ, Statham DJ, Dunne MP, Whitfield JB, Martin NG (1997). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychological Medicine 27, 13811396.
Heath AC, Howells W, Kirk KM, Madden PA, Bucholz KK, Nelson EC, Slutske WS, Statham DJ, Martin NG (2001). Predictors of non-response to a questionnaire survey of a volunteer twin panel: findings from the Australian 1989 twin cohort. Twin Research 4, 7380.
Heim C, Newport DJ, Bonsall R, Miller AH, Nemeroff CB (2001). Altered pituitary–adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse. American Journal of Psychiatry 158, 575581.
Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R, Miller AH, Nemeroff CB (2000). Pituitary–adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. Journal of the American Medical Association 284, 592597.
Hesselbrock M, Easton C, Bucholz KK, Schuckit M, Hesselbrock V (1999). A validity study of the SSAGA – a comparison with the SCAN. Addiction 94, 13611370.
Holmes SJ, Robins LN (1987). The influence of childhood disciplinary experience on the development of alcoholism and depression. Journal of Child Psychology and Psychiatry and Allied Disciplines 28, 399415.
Holmes SJ, Robins LN (1988). The role of parental disciplinary practices in the development of depression and alcoholism. Psychiatry 51, 2436.
Jaffee SR, Moffitt TE, Caspi A, Fombonne E, Poulton R, Martin J (2002). Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Archives of General Psychiatry 59, 215222.
Kaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J (2004). Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences USA 101, 1731617321.
Kendler KS, Bulik CM, Silberg J, Hettema JM, Myers J, Prescott CA (2000). Childhood sexual abuse and adult psychiatric and substance use disorders in women: an epidemiological and cotwin control analysis. Archives of General Psychiatry 57, 953959.
Kendler KS, Gardner CO, Prescott CA (2002). Toward a comprehensive developmental model for major depression in women. American Journal of Psychiatry 159, 11331145.
Kendler KS, Gardner CO, Prescott CA (2006). Toward a comprehensive developmental model for major depression in men. American Journal of Psychiatry 163, 115124.
Kendler KS, Karkowski LM, Prescott CA (1999). Causal relationship between stressful life events and the onset of major depression. American Journal of Psychiatry 156, 837841.
Kendler KS, Karkowski-Shuman L (1997). Stressful life events and genetic liability to major depression: genetic control of exposure to the environment? Psychological Medicine 27, 539547.
Kendler KS, Kessler RC, Walters EE, MacLean C, Neale MC, Heath AC, Eaves LJ (1995). Stressful life events, genetic liability, and onset of an episode of major depression in women. American Journal of Psychiatry 152, 833842.
Kendler KS, Kuhn JW, Prescott CA (2004). Childhood sexual abuse, stressful life events and risk for major depression in women. Psychological Medicine 34, 14751482.
Kendler KS, Kuhn JW, Vittum J, Prescott CA, Riley B (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication. Archives of General Psychiatry 62, 529535.
Kessler RC, Davis CG, Kendler KS (1997). Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey. Psychological Medicine 27, 11011119.
Kessler RC, Magee WJ (1993). Childhood adversities and adult depression: basic patterns of association in a US national survey. Psychological Medicine 23, 679690.
Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, Wittchen HU, Kendler KS (1994). Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Archives of General Psychiatry 51, 819.
Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB (1995). Posttraumatic stress disorder in the National Comorbidity Survey. Archives of General Psychiatry 52, 10481060.
Kovacs M, Devlin B, Pollock M, Richards C, Mukerji P (1997). A controlled family history study of childhood-onset depressive disorder. Archives of General Psychiatry 54, 613623.
Lynskey MT, Glowinski AL, Todorov AA, Bucholz KK, Madden PA, Nelson EC, Statham DJ, Martin NG, Heath AC (2004). Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use. Archives of General Psychiatry 61, 10261032.
Maercker A, Michael T, Fehm L, Becker ES, Margraf J (2004). Age of traumatisation as a predictor of post-traumatic stress disorder or major depression in young women. British Journal of Psychiatry 184, 482487.
Meehl PE (1989). Schizotaxia revisited. Archives of General Psychiatry 46, 935944.
Monroe SM, Simons AD (1991). Diathesis-stress theories in the context of life stress research: implications for the depressive disorders. Psychological Bulletin 110, 406425.
Nelson EC, Heath AC, Madden PA, Cooper ML, Dinwiddie SH, Bucholz KK, Glowinski A, McLaughlin T, Dunne MP, Statham DJ, Martin NG (2002). Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study. Archives of General Psychiatry 59, 139145.
Nemeroff CB, Heim CM, Thase ME, Klein DN, Rush AJ, Schatzberg AF, Ninan PT, McCullough JP Jr., Weiss PM, Dunner DL, Rothbaum BO, Kornstein S, Keitner G, Keller MB (2003). Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. Proceedings of the National Academy of Sciences USA 100, 1429314296.
North CS, Nixon SJ, Shariat S, Mallonee S, McMillen JC, Spitznagel EL, Smith EM (1999). Psychiatric disorders among survivors of the Oklahoma City bombing. Journal of the American Medical Association 282, 755762.
North CS, Smith EM, Spitznagel EL (1997). One-year follow-up of survivors of a mass shooting. American Journal of Psychiatry 154, 16961702.
O'Donnell ML, Creamer M, Pattison P (2004). Posttraumatic stress disorder and depression following trauma: understanding comorbidity. American Journal of Psychiatry 161, 13901396.
Penza KM, Heim C, Nemeroff CB (2003). Neurobiological effects of childhood abuse: implications for the pathophysiology of depression and anxiety. Archives of Women's Mental Health 6, 1522.
Robins LN, Helzer JE, Croughan J, Ratcliff KS (1981). National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity. Archives of General Psychiatry 38, 381389.
Robins LN, Schoenberg SP, Holmes SJ, Ratcliff KS, Benham A, Works J (1985). Early home environment and retrospective recall: a test for concordance between siblings with and without psychiatric disorders. American Journal of Orthopsychiatry 55, 2741.
Rohde P, Lewinsohn PM, Seeley JR (1997). Comparability of telephone and face-to-face interviews in assessing axis I and II disorders. American Journal of Psychiatry 154, 15931598.
SAS Institute (2004). SAS Statistical Software: Release 9.1. SAS Institute, Inc.: Cary, NC.
Spatz-Widom C, DuMont K, Czaja SJ (2007). A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Archives of General Psychiatry 64, 4956.
Spitzer RL, Williams JB, Gibbon M, First MB (1992). The Structured Clinical Interview for DSM-III-R (SCID). I: History, rationale, and description. Archives of General Psychiatry 49, 624629.
Stata Corporation (2004). Stata Statistical Software: Release 8.0. Stata Corporation: College Station, TX.
Sullivan PF, Prescott CA, Kendler KS (2002). The subtypes of major depression in a twin registry. Journal of Affective Disorders 68, 273284.
Swanston HY, Plunkett AM, O'Toole BI, Shrimpton S, Parkinson PN, Oates RK (2003). Nine years after child sexual abuse. Child Abuse and Neglect 27, 967984.
Teicher MH, Dumont NL, Ito Y, Vaituzis C, Giedd JN, Andersen SL (2004). Childhood neglect is associated with reduced corpus callosum area. Biological Psychiatry 56, 8085.
Todd RD, Neuman R, Geller B, Fox LW, Hickok J (1993). Genetic studies of affective disorders: should we be starting with childhood onset probands? Journal of the American Academy of Child and Adolescent Psychiatry 32, 11641171.
Wickramaratne PJ, Greenwald S, Weissman MM (2000). Psychiatric disorders in the relatives of probands with prepubertal-onset or adolescent-onset major depression. Journal of the American Academy of Child and Adolescent Psychiatry 39, 13961405.
Wilhelm K, Mitchell PB, Niven H, Finch A, Wedgwood L, Scimone A, Blair IP, Parker G, Schofield PR (2006). Life events, first depression onset and the serotonin transporter gene. British Journal of Psychiatry 188, 210215.
Williams JB, Gibbon M, First MB, Spitzer RL, Davies M, Borus J, Howes MJ, Kane J, Pope HG, Rounsaville B, Wittchen H (1992). The Structured Clinical Interview for DSM-III-R (SCID). II. Multisite test–retest reliability. Archives of General Psychiatry 49, 630636.
Williamson DE, Ryan ND, Birmaher B, Dahl RE, Kaufman J, Rao U, Puig-Antich J (1995). A case-control family history study of depression in adolescents. Journal of the American Academy of Child and Adolescent Psychiatry 34, 15961607.
Zimmermann P, Bruckl T, Lieb R, Nocon A, Ising M, Beesdo K, Wittchen H-U (2008). The interplay of familial depression liability and adverse events in predicting the first onset of depression during a 10-year follow-up. Biological Psychiatry 63, 406414.
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