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Biological component of the NIMH Clinical Research Branch Collaborative Program on the psychobiology of depression: I. Background and theoretical considerations

  • James W. Maas, Stephen H. Koslow (a1), John M. Davis (a2), Martin M. Katz (a3), Joseph Mendels (a4), Eli Robins (a5), Peter E. Stokes (a6) and Charles L. Bowden (a7)
  • DOI:
  • Published online: 01 July 2009

There are many reports which suggest that patients with affective illness (mania and/or depression) have abnormalities in the functioning of one or more neurobiological systems. At a conference convened by the Clinical Research Branch, Division of Extramural Research Programs, National Institute of Mental Health, these findings were reviewed and some of the factors impeding movement towards a more complete and integrated view of the functioning of neurobiological systems in patients with mania or depression were identified. As a result, a multi-research centre, collaborative approach to the study of the psychobiology of affective disorders was developed. In this collaborative programme, which has now been underway for several years, the focus has been upon: (a) the assessment of the functioning of several different types of biological systems in the same patient, both before and during treatment; (b) obtaining a reasonably large number of patients and comparison subjects; and (c) the use within and across centres of standardized diagnostic categories and behavioural rating methodologies. In this paper the history, background, and rationale for this collaborative effort are reviewed. Those biological systems chosen for study are noted, and issues such as reliability and validity of diagnoses, measurement of state variables, assessment of change with treatment, and logistical and coordinating problems are discussed.

Corresponding author
1Address for correspondence: Professor James W. Maas, Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA.
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W. M. Anderson & J. Dawson (1963). Verbally retarded depression and sodium metabolism. British Journal of Psychiatry 109, 225230.

H. Beckmann & F. K. Goodwin (1975). Antidepressant response to tricyclics and urinary MHPG in unipolar patients. Archives of General Psychiatry 32, 1721.

W. Birkmayer & P. Riedgrer (1975). Biochemical postmortem findings in depressed patients. Journal of Neural Transmission 37, 95107.

M. Bowers (1974). Lumbar CSF, 5-hydroxyindoleacetic acid and homovanillic acid in affective syndromes. Journal of Nervous and Mental Disorders 158, 325330.

W. E. Bunney Jr & J. M. Davis (1965). Norepinephrine in depressive reactions. Archives of General Psychiatry 13, 483494.

E. I. Burdock , G. Hakerem , A. S. Hardesty & J. Zubin (1960). A ward behavior rating scale for use with mental hospital patients. Journal of Clinical Psychology 16, 246247.

B. J. Carroll (1976). Limbic system – adrenal cortex regulation in depression and schizophrenia. Psychosomatic Medicine 38, 106121.

B. J. Carroll , G. C. Curtis & J. Mendels (1976 a). Neuroendocrine regulation in depression. I. Limbic system – adrenocortical dysfunction. Archives of General Psychiatry 33, 10391044.

B. J. Carroll , G. C. Curtis & J. Mendels (1976 b). Neuroendocrine regulation in depression. II. Discrimination of depressed from non-depressed patients. Archives of General Psychiatry 33, 10511058.

A. Coppen (1972). Indoleamines and affective disorders. Journal of Psychiatric Research 9, 163171.

F. T. Crews & C. B. Smith (1978). Presynaptic alphareceptor subsensitivity after long-term antidepressant treatment. Science 202, 322324.

S. J. Dencker , U. Malm , B.-E. Roos & B. Werdinius (1966). Acid monoamine metabolites of cerebrospinal fluid in mental depression and mania. Journal of Neurochemistry 13, 15451548.

E. Dorus , G. N. Pandey & J. M. Davis (1975). Genetic determination of lithium ion distribution: an in vitro and in vitro monozygotic–dyzgotic twin study. Archives of General Psychiatry 32, 10971102.

J. Fawcett , J. W. Maas & H. Dekirmenjian (1972). Depression and MHPG excretion: response to dextroamphetamine and tricyclic antidepressants. Archives of General Psychiatry 26, 246251.

J. P. Feighner , E. Robins , S. B. Guze , R. A. Woodruff , G. Winokur & R. Munoz (1972). Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry 26, 5763.

P. E. Garfinkel , J. J. Warsh , H. C. Stancer & D. D. Godse (1977). CNS monoamine metabolism in bipolar affective disorder. Archives of General Psychiatry 34, 735739.

D. J. Goode , H. Dekirmenjian , H. Y. Meltzer & J. W. Maas (1973). Relation of exercise to MHPG excretion in normal subjects. Archives of General Psychiatry 29, 391396.

J. Greenspan , J. J. Schildkraut , E. K. Gordon , L. Baer , M. S. Aronoff & J. Durell (1970). Catecholamine metabolism in affective disorders. III. 3-Methoxy- 4-hydroxyphenylglycol and other catecholamine metabolites in patients with lithium carbonate. Journal of Psychiatric Research 7, 171183.

P. H. Gruen , E. J. Sachar , N. Altman & J. Sassin (1975). Growth hormone responses to hypoglycemia in post-menopausal depressed women. Archives of General Psychiatry 32, 3133.

M. Hamilton (1967). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6, 278296.

F. Jones , J. W. Maas , H. Dekirmenjian & J. A. Fawcett (1973). Urinary catecholamine metabolites during behavioral changes in a patient with manic depressive cycles. Science 179, 300302.

M. M. Katz & T. M. Itil (1974). Video methodology for research in psychopathology and psychopharmacology. Archives of General Psychiatry 31, 204210.

M. M. Katz , S. K. Secunda , R. M. A. Hirschfeld & S. H. Koslow (1979). NIMH Clinical Research Collaborative Program on the Psychobiology of Depression. Archives of General Psychiatry 36, 765771.

K. Leonhard , I. Korff & H. Schulz (1962). Die Temperament in den Familien der monopolaren und bipolaren phasischen Psychosen. Psychiatria neurologia 143, 416434.

L. C. Lorenzen & W. F. Ganong (1967). Effect of drugs related to alpha-ethyltryptamine on stress-induced ACTH secretion in the dog. Endocrinology 80, 889892.

M. Lorr , T. M. Sonn & M. M. Katz (1967). Toward a definition of depression. Archives of General Psychiatry 17, 183186.

J. W. Maas (1972). Adrenocortical steroid hormones, electrolytes, and the disposition of the catecholamines – a review. Journal of Psychiatric Research 9, 227241.

J. W. Maas (1975). Biogenic amines and depression. Archives of General Psychiatry 32, 13571361.

J. W. Maas , J. A. Fawcett & H. Dekirmenjian (1968). 3-Methoxy-4-hydroxyphenylglycol (MHPG) excretion in depressive states. Archives of General Psychiatry 19, 129134.

J. W. Maas , J. A. Fawcett & H. Dekirmenjian (1972). Catecholamine metabolism, depressive illness, and drug response. Archives of General Psychiatry 26, 252262.

J. Mendels & A. Frazer (1973). Intracellular lithium concentration and clinical response towards a membrane theory of depression. Journal of Psychiatric Research 10,918.

J. Mendels , A. Frazer , R. G. Fitzgerald , T. A. Ramsey & J. W. Stokes (1972). Biogenic amine metabolites in cerebrospinal fluid of depressed and manic patients. Science 175, 13801382.

J. Mendels , J. L. Stinett , D. Burns & A. Frazer (1975). Amine precursors and depression. Archives of General Psychiatry 32, 2230.

G. P. Moberg , U. Scapagnini , Groot J. de & W. F. Ganong (1971). Effect of sectioning the fornix on diurnal fluctuation in plasma corticosterone levels in the rat. Neuroendocrinology 7, 1115.

E. E. Muller (1973). Nervous control of growth hormone secretion. Neuroendocrinology 11, 338369.

D. L. Murphy , M. Baker , F. K. Goodwin & W. E. Bunney (1974).L-Tryptophan in affective disorders. Indoleamine changes and differential clinical effects. Psychopharmacologia 34, 1120.

G. J. Naylor , H. B. McNamee & J. P. Moody (1970 b). The plasma control of erythrocyte sodium and potassium metabolism in depressive illness. Journal of Psychosomatic Research 14, 179186.

J. E. Overall (1962). Dimensions of manifest depression. Psychiatric Research 1, 239245.

D. Pickar , D. R. Sweeney , J. W. Maas & G. R. Heninger (1978). Primary affective disorder, clinical state change and MHPG excretion: a longitudinal study. Archives of General Psychiatry 35(12), 13781383.

R. M. Post , E. K. Gordon , F. K. Goodwin & W. E. Bunney Jr (1973). Central norepinephrine metabolism in affective illness: MHPG in the cerebrospinal fluid. Science 179, 10021003.

R. M. Post , F. J. Stoddard , J. C. Gillin , M. Buchsbaum , D. C. Runkle , R. E. Black & W. E. Bunney Jr (1977).Slow and rapid alterations in motor activity, sleep and biochemistry in a cycling manic-depressive patient. Archives of General Psychiatry 34, 470477.

A. Raskin , J. G. Schulterbrandt , N. Reatig & J. J. McKeon (1969). Replication of factors of psychopathology in interview, ward behavior, and self-ratings of hospitalized depressives. Journal of Nervous and Mental Disease 148, 8798.

J. H. Rey , D. R. C. Wilcox , J. L. Gibbons , H. Tail & D. J. Lewis (1961). Serial biochemical and endocrine investigations in recurrent mental illness. Journal of Psychosomatic Research 5, 155169.

E. Robins , K. A. Gentry , R. A. Munoz & S. Marten (1977). Study and 18-month follow-up of 314 psychiatric emergency room patients: a contrast of the three common illnesses with the ten less common. III. Findings at follow-up. Archives of General Psychiatry 34, 285291.

B.-E. Roos & R. Sjostrom (1969). 5-Hydroxyindoleacetic acid (and homovanillic acid) levels in the cerebrospinal fluid after probenecid application in patients with manic depressive psychosis. Phamacologia clinica 1, 153155.

E. Sacchetti , E. Smeraldi , E. Allaria , M. Cagnasso &P. A. Biondi (1977). A collaborative study. In Mass Spectrometry in Drug Metabolism (ed. A. Frigerio and E. L. Ghisalberti ), pp. 215224, Plenum Press: New York.

E. J. Sachar , L. Hellman , H. P. Roffward , F. S. Halpern , D. K. Fukushima & T. F. Gallagher (1973). Disrupted 24-hour patterns of cortisol secretion in psychotic depression. Archives of General Psychiatry 28, 1924.

U. Scapagnini & P. Preziosi (1973). Receptor involvement in the central noradrenergic inhibition of ACTH secretion in the rat. Neuropharmacology 12, 5762.

U. Scapagnini , G. P. Moberg , G. R. Van Loon , J. de Groot & W. F. Ganong (1971). Relation of brain 5-hydroxy-tryptamine content to the diurnal variation in plasma corticosterone in the rat. Neuroendocrinology 7, 9096.

U. Scapagnini , G. R. Van Loon , G. P. Moberg , P. Preziosi & W. F. Ganong (1972). Evidence for central nor-epinephrine-mediated inhibition of ACTH secretion in the rat. Neuroendocrinology 10, 155160.

J. J. Schildkraut (1973). Norepinephrine metabolites as biochemical criteria for classifying depressive disorders and predicting responses to treatment: preliminary findings. American Journal of Psychiatry 130, 695698.

J. J. Schildkraut & S. S. Kety (1967). Riogenic amines and emotion. Science 156, 2130.

J. J. Schildkraut , A. Winokur & C. W. Applegate (1970). Norepinephrine turnover and metabolism in rat brain after long-term administration of imipramine. Science 168, 867869.

J. J. Schildkraut , B. A. Keeler , M. Papousek & E. Hartmann (1973). MHPG excretion in depressive disorders: relation to clinical subtypes and desynchronized sleep. Science 181, 762764.

D. M. Shaw , F. E. Camps & E. Eccleston (1967). 5-Hydroxytryptamine in the hindbrains of depressive suicides. British Journal of Psychiatry 113, 14071411.

D. M. Shaw , D. Frizel , F. E. Camps & S. White (1969). Brain electrolytes in depressive and alcoholic suicides. British Journal of Psychiatry 115, 6979.

G. P. Smith , R. D. Russ , P. E. Stokes , G. E. Duckett & A. W. Root (1977). Plasma GH response to d-and l-amphetamine in monkeys. Hormone and Metabolic Research 9, 339340.

R. L. Spitzer , J. Endicott & E. Robins (1978). Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry 35, 773782.

P. E. Stokes , G. R. Pick , P. M. Stoll & W. D. Nunn (1975). Pituitary–adrenal function in depressed patients: resistance to dexamethasone suppression. Journal of Psychiatric Research 12, 271281.

F. Sulser , J. Vetulani & P. L. Mobley (1978). Mode of action of antidepressant drugs. Biochemical Pharmacology 27, 257261.

T. H. Svensson & T. Usdin (1978). Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: α-receptor mediation. Science 202, 10891091.

D. Sweeney , J. W. Maas & G. R. Heninger (1978). State anxiety, physical activity and urinary 3-methoxy-4-hydroxymethylene glycol excretion. Archives of General Psychiatry 35, 14181423.

S. Wilk , B. Shopsin , S. Gershon & M. Suhl (1972). Catecholamines and affective disorders: levels of MHPG in cerebrospinal fluid. Nature 235, 440442.

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