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Chronic exposure to haloperidol and olanzapine leads to common and divergent shape changes in the rat hippocampus in the absence of grey-matter volume loss

  • W. R. Crum (a1), F. Danckaers (a2), T. Huysmans (a2), M.-C. Cotel (a3), S. Natesan (a3), M. M. Modo (a4), J. Sijbers (a2), S. C. R. Williams (a1), S. Kapur (a3) and A. C. Vernon (a3) (a4)...



One of the most consistently reported brain abnormalities in schizophrenia (SCZ) is decreased volume and shape deformation of the hippocampus. However, the potential contribution of chronic antipsychotic medication exposure to these phenomena remains unclear.


We examined the effect of chronic exposure (8 weeks) to clinically relevant doses of either haloperidol (HAL) or olanzapine (OLZ) on adult rat hippocampal volume and shape using ex vivo structural MRI with the brain retained inside the cranium to prevent distortions due to dissection, followed by tensor-based morphometry (TBM) and elastic surface-based shape deformation analysis. The volume of the hippocampus was also measured post-mortem from brain tissue sections in each group.


Chronic exposure to either HAL or OLZ had no effect on the volume of the hippocampus, even at exploratory thresholds, which was confirmed post-mortem. In contrast, shape deformation analysis revealed that chronic HAL and OLZ exposure lead to both common and divergent shape deformations (q = 0.05, FDR-corrected) in the rat hippocampus. In particular, in the dorsal hippocampus, HAL exposure led to inward shape deformation, whereas OLZ exposure led to outward shape deformation. Interestingly, outward shape deformations that were common to both drugs occurred in the ventral hippocampus. These effects remained significant after controlling for hippocampal volume suggesting true shape changes.


Chronic exposure to either HAL or OLZ leads to both common and divergent effects on rat hippocampal shape in the absence of volume change. The implications of these findings for the clinic are discussed.

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      Chronic exposure to haloperidol and olanzapine leads to common and divergent shape changes in the rat hippocampus in the absence of grey-matter volume loss
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Corresponding author

*Address for correspondence: Dr A. C. Vernon, Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute for Clinical Neuroscience, 5 Cutcombe Road, London SE5 9RT, UK. (Email:


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Altshuler, LL, Bartzokis, G, Grieder, T, Curran, J, Jimenez, T, Leight, K, Wilkins, J, Gerner, R, Mintz, J (2000). An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biological Psychiatry 48, 147162.
Ansell, BR, Dwyer, DB, Wood, SJ, Bora, E, Brewer, WJ, Proffitt, TM, Velakoulis, D, McGorry, PD, Pantelis, C (2015). Divergent effects of first-generation and second-generation antipsychotics on cortical thickness in first-episode psychosis. Psychological Medicine 45, 515527.
Arango, C, Breier, A, McMahon, R, Carpenter, WT Jr., Buchanan, RW (2003). The relationship of clozapine and haloperidol treatment response to prefrontal, hippocampal, and caudate brain volumes. American Journal of Psychiatry 160, 14211427.
Bannerman, DM, Rawlins, JN, McHugh, SB, Deacon, RM, Yee, BK, Bast, T, Zhang, WN, Pothuizen, HH, Feldon, J (2004). Regional dissociations within the hippocampus – memory and anxiety. Neuroscience Biobehavioural Reviews 28, 273283.
Barkus, C, McHugh, SB, Sprengel, R, Seeburg, PH, Rawlins, JN, Bannerman, DM (2010). Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion. European Journal of Pharmacology 626, 4956.
Barnes, SA, Sawiak, SJ, Caprioli, D, Jupp, B, Buonincontri, G, Mar, AC, Harte, MK, Fletcher, PC, Robbins, TW, Neill, JC, Dalley, JW (2015). Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia. International Journal of Neuropsychopharmacology 18, 112.
Barr, AM, Wu, CH, Wong, C, Hercher, C, Topfer, E, Boyda, HN, Procyshyn, RM, Honer, WG, Beasley, CL (2013). Effects of chronic exercise and treatment with the antipsychotic drug olanzapine on hippocampal volume in adult female rats. Neuroscience 255, 147157.
Boyda, HN, Tse, L, Procyshyn, RM, Honer, WG, Barr, AM (2010). Preclinical models of antipsychotic drug-induced metabolic side effects. Trends in Pharmacological Sciences 31, 484497.
Cotel, MC, Lenartowicz, EM, Natesan, S, Modo, MM, Cooper, JD, Williams, SC, Kapur, S, Vernon, AC (2015). Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses. European Neuropsychopharmacology 25, 20982107.
Crum, WR, Modo, M, Vernon, AC, Barker, GJ, Williams, SC (2013). Registration of challenging pre-clinical brain images. Journal of Neuroscience Methods 216, 6277.
Csernansky, JG, Joshi, S, Wang, L, Haller, JW, Gado, M, Miller, JP, Grenander, U, Miller, MI (1998). Hippocampal morphometry in schizophrenia by high dimensional brain mapping. Proceedings of the National Academy Science USA 95, 1140611411.
Csernansky, JG, Wang, L, Jones, D, Rastogi-Cruz, D, Posener, JA, Heydebrand, G, Miller, JP, Miller, MI (2002). Hippocampal deformities in schizophrenia characterized by high dimensional brain mapping. American Journal of Psychiatry 159, 20002006.
Danckaers, F, Huysmans, T, Lacko, D, Ledda, A, Verwulgen, S, Van Dongen, S, Sijbers, J (2014). Correspondance preserving elastic surface registration with shape model prior. Pattern Recognition (International Conference on Pattern Recognition) 22, 21432148.
Dean, DJ, Orr, JM, Bernard, JA, Gupta, T, Pelletier-Baldelli, A, Carol, EE, Mittal, VA (2016). Hippocampal shape abnormalities predict symptom progression in neuroleptic-free youth at ultrahigh risk for psychosis. Schizophrenia Bulletin 42, 161169.
Delgado y Palacios, R, Campo, A, Henningsen, K, Verhoye, M, Poot, D, Dijkstra, J, Van Audekerke, J, Benveniste, H, Sijbers, J, Wiborg, O, Van der Linden, A (2011). Magnetic resonance imaging and spectroscopy reveal differential hippocampal changes in anhedonic and resilient subtypes of the chronic mild stress rat model. Biological Psychiatry 70, 449457.
Didriksen, M, Kreilgaard, M, Arnt, J (2006). Sertindole, in contrast to clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment. European Journal Pharmacology 542, 108115.
Dorph-Petersen, KA, Pierri, JN, Perel, JM, Sun, Z, Sampson, AR, Lewis, DA (2005). The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: a comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacology 30, 16491661.
Ebdrup, BH, Skimminge, A, Rasmussen, H, Aggernaes, B, Oranje, B, Lublin, H, Baare, W, Glenthoj, B (2011). Progressive striatal and hippocampal volume loss in initially antipsychotic-naive, first-episode schizophrenia patients treated with quetiapine: relationship to dose and symptoms. International Journal of Neuropsychopharmacology 14, 6982.
Fanselow, MS, Dong, HW (2010). Are the dorsal and ventral hippocampus functionally distinct structures? Neuron 65, 719.
Gass, N, Schwarz, AJ, Sartorius, A, Cleppien, D, Zheng, L, Schenker, E, Risterucci, C, Meyer-Lindenberg, A, Weber-Fahr, W (2013). Haloperidol modulates midbrain-prefrontal functional connectivity in the rat brain. European Neuropsychopharmacology 23, 13101319.
Genovese, CR, Lazar, NA, Nichols, T (2002). Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 15, 870878.
Gundersen, HJ, Jensen, EB (1987). The efficiency of systematic sampling in stereology and its prediction. Journal of Microscopy 147, 229263.
Gur, RE, Turetsky, BI, Cowell, PE, Finkelman, C, Maany, V, Grossman, RI, Arnold, SE, Bilker, WB, Gur, RC (2000). Temporolimbic volume reductions in schizophrenia. Archives of General Psychiatry 57, 769775.
Harrison, IF, Crum, WR, Vernon, AC, Dexter, DT (2015). Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors. British Journal of Pharmacology 172, 42004215.
Ho, BC, Andreasen, NC, Ziebell, S, Pierson, R, Magnotta, V (2011). Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Archives of General Psychiatry 68, 128137.
Hutchings, EJ, Waller, JL, Terry, AV Jr (2013). Differential long-term effects of haloperidol and risperidone on the acquisition and performance of tasks of spatial working and short-term memory and sustained attention in rats. Journal of Pharmacology and Experimental Therapeutics 347, 547556.
Jenkinson, M, Bannister, P, Brady, M, Smith, S (2002). Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17, 825841.
Jenkinson, M, Smith, S (2001). A global optimisation method for robust affine registration of brain images. Medical Image Analysis 5, 143156.
Kapur, S, VanderSpek, SC, Brownlee, BA, Nobrega, JN (2003). Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy. Journal of Pharmacology Experimental Therapeutics 305, 625631.
Konopaske, GT, Dorph-Petersen, KA, Sweet, RA, Pierri, JN, Zhang, W, Sampson, AR, Lewis, DA (2008). Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biological Psychiatry 63, 759765.
Koolschijn, PC, van Haren, NE, Cahn, W, Schnack, HG, Janssen, J, Klumpers, F, Hulshoff Pol, HE, Kahn, RS (2010). Hippocampal volume change in schizophrenia. Journal of Clinical Psychiatry 71, 737744.
Lau, JC, Lerch, JP, Sled, JG, Henkelman, RM, Evans, AC, Bedell, BJ (2008). Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease. Neuroimage 42, 1927.
Lerch, JP, Carroll, JB, Spring, S, Bertram, LN, Schwab, C, Hayden, MR, Henkelman, RM (2008). Automated deformation analysis in the YAC128 Huntington disease mouse model. Neuroimage 39, 3239.
Leucht, S, Corves, C, Arbter, D, Engel, RR, Li, C, Davis, JM (2009). Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet 373, 3141.
Lewis, DA (2011). Antipsychotic medications and brain volume: do we have cause for concern? Archives of General Psychiatry 68, 126127.
Lieberman, JA, Tollefson, GD, Charles, C, Zipursky, R, Sharma, T, Kahn, RS, Keefe, RS, Green, AI, Gur, RE, McEvoy, J, Perkins, D, Hamer, RM, Gu, H, Tohen, M (2005). Antipsychotic drug effects on brain morphology in first-episode psychosis. Archives of General Psychiatry 62, 361370.
Mamah, D, Alpert, KI, Barch, DM, Csernansky, JG, Wang, L (2016). Subcortical neuromorphometry in schizophrenia spectrum and bipolar disorders. Neuroimage Clinical 11, 276286.
Mamah, D, Harms, MP, Barch, D, Styner, M, Lieberman, JA, Wang, L (2012). Hippocampal shape and volume changes with antipsychotics in early stage psychotic illness. Frontiers in Psychiatry 3, 96.
Marsh, L, Suddath, RL, Higgins, N, Weinberger, DR (1994). Medial temporal lobe structures in schizophrenia: relationship of size to duration of illness. Schizophrenia Research 11, 225238.
McClure, RK, Carew, K, Greeter, S, Maushauer, E, Steen, G, Weinberger, DR (2008). Absence of regional brain volume change in schizophrenia associated with short-term atypical antipsychotic treatment. Schizophrenia Research 98, 2939.
McClure, RK, Phillips, I, Jazayerli, R, Barnett, A, Coppola, R, Weinberger, DR (2006). Regional change in brain morphometry in schizophrenia associated with antipsychotic treatment. Psychiatry Research 148, 121132.
McClure, RK, Styner, M, Maltbie, E, Lieberman, JA, Gouttard, S, Gerig, G, Shi, X, Zhu, H (2013). Localized differences in caudate and hippocampal shape are associated with schizophrenia but not antipsychotic type. Psychiatry Research 211, 110.
McHugh, SB, Deacon, RM, Rawlins, JN, Bannerman, DM (2004). Amygdala and ventral hippocampus contribute differentially to mechanisms of fear and anxiety. Behavioural Neuroscience 118, 6378.
Mondelli, V, Anacker, C, Vernon, AC, Cattaneo, A, Natesan, S, Modo, M, Dazzan, P, Kapur, S, Pariante, CM (2013). Haloperidol and olanzapine mediate metabolic abnormalities through different molecular pathways. Translational Psychiatry 3, e208.
Moser, MB, Moser, EI (1998). Functional differentiation in the hippocampus. Hippocampus 8, 608619.
Narr, KL, Thompson, PM, Szeszko, P, Robinson, D, Jang, S, Woods, RP, Kim, S, Hayashi, KM, Asunction, D, Toga, AW, Bilder, RM (2004). Regional specificity of hippocampal volume reductions in first-episode schizophrenia. Neuroimage 21, 15631575.
Panenka, WJ, Khorram, B, Barr, AM, Smith, GN, Lang, DJ, Kopala, LC, Vandorpe, RA, Honer, WG (2007). A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia. Schizophrenia Research 94, 288292.
Pillai, A, Mahadik, SP (2006). Differential effects of haloperidol and olanzapine on levels of vascular endothelial growth factor and angiogenesis in rat hippocampus. Schizophrenia Research 87, 4859.
Pillai, A, Terry, AV Jr, Mahadik, SP (2006). Differential effects of long-term treatment with typical and atypical antipsychotics on NGF and BDNF levels in rat striatum and hippocampus. Schizophrenia Research 82, 95106.
Piontkewitz, Y, Arad, M, Weiner, I (2011). Abnormal trajectories of neurodevelopment and behavior following in utero insult in the rat. Biological Psychiatry 70, 842851.
Reinke, A, Martins, MR, Lima, MS, Moreira, JC, Dal-Pizzol, F, Quevedo, J (2004). Haloperidol and clozapine, but not olanzapine, induces oxidative stress in rat brain. Neuroscience Letters 372, 157160.
Schobel, SA, Chaudhury, NH, Khan, UA, Paniagua, B, Styner, MA, Asllani, I, Inbar, BP, Corcoran, CM, Lieberman, JA, Moore, H, Small, SA (2013). Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver. Neuron 78, 8193.
Schobel, SA, Lewandowski, NM, Corcoran, CM, Moore, H, Brown, T, Malaspina, D, Small, SA (2009). Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders. Archives of General Psychiatry 66, 938946.
Shenton, ME, Gerig, G, McCarley, RW, Szekely, G, Kikinis, R (2002). Amygdala-hippocampal shape differences in schizophrenia: the application of 3D shape models to volumetric MR data. Psychiatry Research 115, 1535.
Skarsfeldt, T (1996). Differential effect of antipsychotics on place navigation of rats in the Morris water maze. A comparative study between novel and reference antipsychotics. Psychopharmacology (Berlin) 124, 126133.
Small, SA, Schobel, SA, Buxton, RB, Witter, MP, Barnes, CA (2011). A pathophysiological framework of hippocampal dysfunction in ageing and disease. Nature Reviews Neuroscience 12, 585601.
Stefanis, N, Frangou, S, Yakeley, J, Sharma, T, O'Connell, P, Morgan, K, Sigmudsson, T, Taylor, M, Murray, R (1999). Hippocampal volume reduction in schizophrenia: effects of genetic risk and pregnancy and birth complications. Biological Psychiatry 46, 697702.
Szeszko, PR, Goldberg, E, Gunduz-Bruce, H, Ashtari, M, Robinson, D, Malhotra, AK, Lencz, T, Bates, J, Crandall, DT, Kane, JM, Bilder, RM (2003). Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophrenia. American Journal of Psychiatry 160, 21902197.
Terry, AV Jr, Mahadik, SP (2007). Time-dependent cognitive deficits associated with first and second generation antipsychotics: cholinergic dysregulation as a potential mechanism. Journal of Pharmacology and Experimental Therapeutics 320, 961968.
Uranova, NA, Orlovskaya, DD, Apel, K, Klintsova, AJ, Haselhorst, U, Schenk, H (1991). Morphometric study of synaptic patterns in the rat caudate nucleus and hippocampus under haloperidol treatment. Synapse 7, 253259.
van Erp, TG, Hibar, DP, Rasmussen, JM, Glahn, DC, Pearlson, GD, Andreassen, OA, Agartz, I, Westlye, LT, Haukvik, UK, Dale, AM, Melle, I, Hartberg, CB, Gruber, O, Kraemer, B, Zilles, D, Donohoe, G, Kelly, S, McDonald, C, Morris, DW, Cannon, DM, Corvin, A, Machielsen, MW, Koenders, L, de Haan, L, Veltman, DJ, Satterthwaite, TD, Wolf, DH, Gur, RC, Gur, RE, Potkin, SG, Mathalon, DH, Mueller, BA, Preda, A, Macciardi, F, Ehrlich, S, Walton, E, Hass, J, Calhoun, VD, Bockholt, HJ, Sponheim, SR, Shoemaker, JM, van Haren, NE, Pol, HE, Ophoff, RA, Kahn, RS, Roiz-Santianez, R, Crespo-Facorro, B, Wang, L, Alpert, KI, Jonsson, EG, Dimitrova, R, Bois, C, Whalley, HC, McIntosh, AM, Lawrie, SM, Hashimoto, R, Thompson, PM, Turner, JA (2015). Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Molecular Psychiatry 21, 547553.
van Haren, NE, Schnack, HG, Cahn, W, van den Heuvel, MP, Lepage, C, Collins, L, Evans, AC, Hulshoff Pol, HE, Kahn, RS (2011). Changes in cortical thickness during the course of illness in schizophrenia. Archives of General Psychiatry 68, 871880.
Velakoulis, D, Wood, SJ, Wong, MT, McGorry, PD, Yung, A, Phillips, L, Smith, D, Brewer, W, Proffitt, T, Desmond, P, Pantelis, C (2006). Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Archives of General Psychiatry 63, 139149.
Vernon, AC, Crum, WR, Lerch, JP, Chege, W, Natesan, S, Modo, M, Cooper, JD, Williams, SC, Kapur, S (2014). Reduced cortical volume and elevated astrocyte density in rats chronically treated with antipsychotic drugs-linking magnetic resonance imaging findings to cellular pathology. Biological Psychiatry 75, 982990.
Vernon, AC, Natesan, S, Crum, WR, Cooper, JD, Modo, M, Williams, SC, Kapur, S (2012). Contrasting effects of haloperidol and lithium on rodent brain structure: a magnetic resonance imaging study with postmortem confirmation. Biological Psychiatry 71, 855863.
Vernon, AC, Natesan, S, Modo, M, Kapur, S (2011). Effect of chronic antipsychotic treatment on brain structure: a serial magnetic resonance imaging study with ex vivo and postmortem confirmation. Biological Psychiatry 69, 936944.
Vita, A, De Peri, L, Deste, G, Barlati, S, Sacchetti, E (2015). The effect of antipsychotic treatment on cortical gray matter changes in Schizophrenia: does the class matter? A meta-analysis and meta-regression of longitudinal magnetic resonance imaging studies. Biological Psychiatry 78, 403412.
Wang, L, Joshi, SC, Miller, MI, Csernansky, JG (2001). Statistical analysis of hippocampal asymmetry in schizophrenia. Neuroimage 14, 531545.
Watson, C, Paxinos, G (2007). The Rat Brain in Stereotaxic Co-Ordinates. Academic Press: London.
Wheeler, AL, Creed, MC, Voineskos, AN, Nobrega, JN (2014). Changes in brain functional connectivity after chronic haloperidol in rats: a network analysis. International Journal of Neuropsychopharmacology 17, 11291138.
Wheeler, AL, Lerch, JP, Chakravarty, MM, Friedel, M, Sled, JG, Fletcher, PJ, Josselyn, SA, Frankland, PW (2013). Adolescent cocaine exposure causes enduring macroscale changes in mouse brain structure. Journal of Neuroscience 33, 17971803.
Whitworth, AB, Honeder, M, Kremser, C, Kemmler, G, Felber, S, Hausmann, A, Wanko, C, Wechdorn, H, Aichner, F, Stuppaeck, CH, Fleischhacker, WW (1998). Hippocampal volume reduction in male schizophrenic patients. Schizophrenia Research 31, 7381.
Wolf, OT, Dyakin, V, Vadasz, C, de Leon, MJ, McEwen, BS, Bulloch, K (2002). Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI. Brain Research Brain Research Protocols 10, 4146.
Yushkevich, PA, Piven, J, Hazlett, HC, Smith, RG, Ho, S, Gee, JC, Gerig, G (2006). User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 31, 11161128.
Zierhut, K, Bogerts, B, Schott, B, Fenker, D, Walter, M, Albrecht, D, Steiner, J, Schutze, H, Northoff, G, Duzel, E, Schiltz, K (2010). The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophrenia. Psychiatry Research 183, 187194.
Zierhut, KC, Grassmann, R, Kaufmann, J, Steiner, J, Bogerts, B, Schiltz, K (2013). Hippocampal CA1 deformity is related to symptom severity and antipsychotic dosage in schizophrenia. Brain 136, 804814.


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Chronic exposure to haloperidol and olanzapine leads to common and divergent shape changes in the rat hippocampus in the absence of grey-matter volume loss

  • W. R. Crum (a1), F. Danckaers (a2), T. Huysmans (a2), M.-C. Cotel (a3), S. Natesan (a3), M. M. Modo (a4), J. Sijbers (a2), S. C. R. Williams (a1), S. Kapur (a3) and A. C. Vernon (a3) (a4)...


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