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Common genetic and environmental contributions to post-traumatic stress disorder and alcohol dependence in young women

  • C. E. Sartor (a1), V. V. McCutcheon (a1), N. E. Pommer (a1), E. C. Nelson (a1), J. D. Grant (a1), A. E. Duncan (a1), M. Waldron (a1) (a2), K. K. Bucholz (a1), P. A. F. Madden (a1) and A. C. Heath (a1)...
Abstract
Background

The few genetically informative studies to examine post-traumatic stress disorder (PTSD) and alcohol dependence (AD), all of which are based on a male veteran sample, suggest that the co-morbidity between PTSD and AD may be attributable in part to overlapping genetic influences, but this issue has yet to be addressed in females.

Method

Data were derived from an all-female twin sample (n=3768) ranging in age from 18 to 29 years. A trivariate genetic model that included trauma exposure as a separate phenotype was fitted to estimate genetic and environmental contributions to PTSD and the degree to which they overlap with those that contribute to AD, after accounting for potential confounding effects of heritable influences on trauma exposure.

Results

Additive genetic influences (A) accounted for 72% of the variance in PTSD; individual-specific environmental (E) factors accounted for the remainder. An AE model also provided the best fit for AD, for which heritability was estimated to be 71%. The genetic correlation between PTSD and AD was 0.54.

Conclusions

The heritability estimate for PTSD in our sample is higher than estimates reported in earlier studies based almost exclusively on an all-male sample in which combat exposure was the precipitating traumatic event. However, our findings are consistent with the absence of evidence for shared environmental influences on PTSD and, most importantly, the substantial overlap in genetic influences on PTSD and AD reported in these investigations. Additional research addressing potential distinctions by gender in the relative contributions of genetic and environmental influences on PTSD is merited.

Copyright
Corresponding author
*Address for correspondence: C. E. Sartor, Ph.D., Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, Saint Louis, MI 63110, USA. (Email: sartorc@psychiatry.wustl.edu)
References
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Afifi TO, Asmundson GJG, Taylor S, Jang KL (2010). The role of genes and environment on trauma exposure and posttraumatic stress disorder symptoms: a review of twin studies. Clinical Psychology Review 30, 101112.
Bierut LJ, Heath AC, Bucholz KK, Dinwiddie SH, Madden PAF, Statham DJ, Dunne MP, Martin NG (1999). Major depressive disorder in a community-based twin sample: are there different genetic and environmental contributions for men and women? Archives of General Psychiatry 56, 557562.
Breslau N, Davis GC, Peterson EL, Schultz L (1997). Psychiatric sequelae of posttraumatic stress disorder in women. Archives of General Psychiatry 54, 8187.
Breslau N, Kessler RC, Chilcoat HD, Schultz LR, Davis GC, Andreski P (1998). Trauma and posttraumatic stress disorder in the community. Archives of General Psychiatry 55, 626632.
Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger Jr. JI, Reich T, Schmidt I, Schuckit MA (1994). A new, semi-structured psychiatric interview for use in genetic linkage studies: a report of the reliability of the SSAGA. Journal of Studies on Alcohol 55, 149158.
Chilcoat HD, Breslau N (1998). Investigations of causal pathways between PTSD and drug use disorders. Addictive Behaviors 23, 827840.
Danielson CK, Amstandter AB, Dangelmaier RE, Resnick HE, Saunders BE, Kilpatrick DG (2009). Trauma-related risk factors for substance abuse among male versus female young adults. Addictive Behaviors 34, 395399.
Fergusson DM, Horwood LJ, Lynskey MT (1996). Childhood sexual abuse and psychiatric disorder in young adulthood: II. Journal of the American Academy of Child and Adolescent Psychiatry 35, 13651374.
Franic S, Middledorp CM, Dolan CV, Ligthart L, Boomsma DI (2010). Childhood and adolescent anxiety and depression. Journal of the American Academy of Child and Adolescent Psychiatry 49, 820829.
Hapke U, Schumann A, Rumpf H, John U, Meyer C (2006). Post-traumatic stress disorder: the role of trauma, pre-existing psychiatric disorders, and gender. European Archives of Psychiatry and Clinical Neuroscience 256, 299306.
Hasin DS, Stinson FS, Ogburn E, Grant BF (2007). Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiological Survey on Alcohol and Related Conditions. Archives of General Psychiatry 64, 830842.
Heath AC, Bucholz KK, Madden PA, Dinwiddie SH, Slutske WS, Bierut RJ, Statham DJ, Dunne NP, Whitfield JB, Martin NG (1997). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychological Medicine 27, 13811396.
Heath AC, Howells W, Bucholz KK, Glowinski AL, Nelson EC, Madden PA (2002). Ascertainment of a mid-western U.S. female adolescent twin cohort for alcohol studies: assessment of sample representativeness using birth record data. Twin Research 5, 107112.
Heath AC, Martin NG, Lynskey MT, Todorov AA, Madden PAF (2004). Estimating two-stage models for genetic influences on alcohol, tobacco or drug use initiation and dependence vulnerability in twin and family data. Twin Research 5, 113124.
Hesselbrock M, Easton C, Bucholz KK, Schuckit M, Hesselbrock V (1999). A validity study of the SSAGA: a comparison with the SCAN. Addiction 94, 13611370.
Hettema JM, Prescott CA, Myers JM, Neale MC, Kendler KS (2005). The structure of genetic and environmental risk factors for anxiety disorders in men and women. Archives of General Psychiatry 62, 182189.
Holdcraft LC, Iacono WG (2002). Cohort effects on gender differences in alcohol dependence. Addiction 97, 10251036.
Jang KL, Stein MB, Taylor S, Asmundson GJG, Livesley WJ (2003). Exposure to traumatic events and experiences: aetiological relationships with personality function. Psychiatry Research 120, 61–19.
Kendler KS, Neale MC, Heath AC, Kessler RC, Eaves LC (1994). A twin-family study of alcoholism in women. American Journal of Psychiatry 151, 707715.
Kendler KS, Prescott CA, Myers J, Neale MC (2003). The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Archives of General Psychiatry 60, 929937.
Kessler RC, Crum RM, Warner LA, Nelson CB, Schulenberg J, Anthony JC (1997). Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Archives of General Psychiatry 54, 313321.
Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB (1995). Posttraumatic stress disorder in the National Comorbidity Survey. Archives of General Psychiatry 52, 10481060.
Keyes KM, Grant BF, Hasin DS (2008). Evidence for a closing gender gap in alcohol use, abuse, and dependence in the United States population. Drug and Alcohol Dependence 93, 2129.
Kilpatrick DG, Acierno R, Resnick HS, Saunders BE, Best CL (1997). A 2-year longitudinal analysis of the relationship between violent assault and substance use in women. Journal of Consulting and Clinical Psychology 65, 834847.
Koenen KC, Fu QJ, Ertel K, Lyons MJ, Eisen SA, True WR, Goldberg J, Tsuang MT (2008). Common genetic liability to major depression and posttraumatic stress disorder in men. Journal of Affective Disorders 105, 109115.
Koenen KC, Lyons MJ, Goldberg J, Simpson J, Williams WM, Toomey R, Eisen SA, True WR, Cloitre M, Wolfe J, Tsuang M (2003). A high risk study of combat-related PTSD comorbidity. Twin Research 6, 218226.
Lyons MJ, Goldberg J, Eisen SA, True W, Tsuang MT, Meyer JM, Henderson WG (1993). Do genes influence exposure to trauma? A twin study of combat. American Journal of Medical Genetics (Neuropsychiatric Genetics) 8, 2227.
McCutcheon VV, Sartor CE, Pommer NE, Bucholz KK, Nelson EC, Madden PAF, Heath AC (in press). Age at trauma exposure and PTSD risk in a young adult female sample. Journal of Traumatic Stress.
Neale MC, Boker SM, Xie G, Maes HH (2003). Mx: Statistical Modeling, 6th edn. Virginia Commonwealth University: Richmond, VA.
Perkonigg A, Kessler RC, Storz S, Wittchen H (2000). Traumatic events and post-traumatic stress disorder in the community: prevalence, risk factors and comorbidity. Acta Psychiatrica Scandinavica 101, 4659.
Prescott CA, Aggen SH, Kendler KS (1999). Sex differences in the sources of genetic liability to alcohol abuse and dependence in a population-based sample of U.S. twins. Alcoholism: Clinical and Experimental Research 23, 11361144.
Reed T, Page WF, Viken RJ, Christian JC (1996). Genetic predisposition to organ-specific endpoints of alcoholism. Alcoholism: Clinical and Experimental Research 20, 15281533.
Resnick HS, Kilpatrick DG, Dansky BS, Saunders BE, Best CL (1993). Prevalence of civilian trauma and posttraumatic stress disorder in a representative national sample of women. Journal of Consulting and Clinical Psychology 61, 984991.
Scherrer JF, Xian H, Lyons MJ, Goldberg J, Eisen SA, True WR, Tsuang M, Bucholz KK, Koenen KC (2008). Posttraumatic stress disorder; combat exposure; and nicotine dependence, alcohol dependence, and major depression in male twins. Comprehensive Psychiatry 49, 297304.
Seedat S, Niehaus DJ, Stein DJ (2001). The roles of genes and family in trauma exposure and posttraumatic stress disorder. Molecular Psychiatry 6, 360362.
Stein MB, Jang KL, Taylor S, Vernon PA, Livesley WJ (2002). Genetic and environmental influences on trauma exposure and posttraumatic stress disorder symptoms: a twin study. American Journal of Psychiatry 159, 16751681.
True WR, Heath AC, Bucholz KK, Slutske W, Romeis JC, Scherrer JF, Lin N, Eisen SA, Goldberg J, Lyons MJ, Tsuang MT (1996). Models of treatment seeking for alcoholism: the role of genes and environment. Alcoholism: Clinical and Experimental Research 20, 15771581.
True WR, Rice J, Eisen SA, Heath AC, Goldberg J, Lyons MJ, Nowak J (1993). A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms. Archives of General Psychiatry 50, 257264.
van den Bree MBM, Johnson EO, Neale MC, Svikis DS, McGue M, Pickens RW (1998). Genetic analysis of diagnostic systems of alcoholism in males. Biological Psychiatry 43, 139145.
Wilsnack SC, Vogeltanz ND, Klassen AD, Harris TR (1997). Childhood sexual abuse and women's substance abuse: national survey findings. Journal of Studies on Alcohol 58, 264271.
Xian H, Chantarujikapong SI, Scherrer JF, Eisen SA, Lyons MJ, Goldberg J, Tsuang M, True WR (2000). Genetic and environmental influences on posttraumatic stress disorder, alcohol and drug dependence in twin pairs. Drug and Alcohol Dependence 61, 95102.
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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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