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Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a randomized, double-blind, controlled trial


A detailed analysis of the results of a multi-centre clinical trial shows that, while the relapse rate following recovery from an operationally defined depressive illness was smaller among patients subsequently treated with either amitryptiline or lithium than with a placebo, there was no clinically significant difference between the prophylactic efficacy of the 2 antidepressants. An account is given of the relative adverse effects of the treatments, and the implications of the findings are discussed.

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3 Address for correspondence: Professor Michael Shepherd Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.
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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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