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The contribution of brain imaging to the understanding of psychopathy

  • Jesus Pujol (a1), Ben J. Harrison (a2), Oren Contreras-Rodriguez (a3) and Narcis Cardoner (a4)
Abstract

Psychopathy is a personality type characterized by both callous emotional dysfunction and deviant behavior that affects society in the form of actions that harm others. Historically, researchers have been concerned with seeking data and arguments to support a neurobiological foundation of psychopathy. In the past few years, increasing research has begun to reveal brain alterations putatively underlying the enigmatic psychopathic personality. In this review, we describe the brain anatomical and functional features that characterize psychopathy from a synthesis of available neuroimaging research and discuss how such brain anomalies may account for psychopathic behavior. The results are consistent in showing anatomical alterations involving primarily a ventral system connecting the anterior temporal lobe to anterior and ventral frontal areas, and a dorsal system connecting the medial frontal lobe to the posterior cingulate cortex/precuneus complex and, in turn, to medial structures of the temporal lobe. Functional imaging data indicate that relevant emotional flow breakdown may occur in both these brain systems and suggest specific mechanisms via which emotion is anomalously integrated into cognition in psychopathic individuals during moral challenge. Directions for future research are delineated emphasizing, for instance, the relevance of further establishing the contribution of early life stress to a learned blockage of emotional self-exposure, and the potential role of androgenic hormones in the development of cortical anomalies.

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Corresponding author
Author for correspondence: Jesus Pujol, E-mail: 21404jpn@comb.cat
References
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Aharoni, E, Vincent, GM, Harenski, CL, Calhoun, VD, Sinnott-Armstrong, W, Gazzaniga, MS and Kiehl, KA (2013) Neuroprediction of future rearrest. Proceedings of the National Academy of Sciences of the USA 110, 62236228.
American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders, 5th Edn. Arlington, VA: American Psychiatric Association.
Anderson, SW, Bechara, A, Damasio, H, Tranel, D and Damasio, AR (1999) Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nature Neuroscience 2, 10321037.
Aoki, Y, Inokuchi, R, Nakao, T and Yamasue, H (2014) Neural bases of antisocial behavior: a voxel-based meta-analysis. Social Cognitive and Affective Neuroscience 9, 12231231.
Arnold, AP and Gorski, RA (1984) Gonadal steroid induction of structural sex differences in the central nervous system. Annual Review of Neuroscience 7, 413442.
Bado, P, Engel, A, de Oliveira-Souza, R, Bramati, IE, Paiva, FF, Basilio, R, Sato, JR, Tovar-Moll, F and Moll, J (2014) Functional dissociation of ventral frontal and dorsomedial default mode network components during resting state and emotional autobiographical recall. Human Brain Mapping 35, 33023313.
Barkataki, I, Kumari, V, Das, M, Taylor, P and Sharma, T (2006) Volumetric structural brain abnormalities in men with schizophrenia or antisocial personality disorder. Behavioural Brain Research 169, 239247.
Baskin-Sommers, AR, Brazil, IA, Ryan, J, Kohlenberg, NJ, Neumann, CS and Newman, JP (2015) Mapping the association of global executive functioning onto diverse measures of psychopathic traits. Personality Disorders 6, 336346.
Baskin-Sommers, AR, Neumann, CS, Cope, LM and Kiehl, KA (2016) Latent-variable modeling of brain gray-matter volume and psychopathy in incarcerated offenders. Journal of Abnormal Psychology 125, 811817.
Bertsch, K, Grothe, M, Prehn, K, Vohs, K, Berger, C, Hauenstein, K, Keiper, P, Domes, G, Teipel, S and Herpertz, SC (2013) Brain volumes differ between diagnostic groups of violent criminal offenders. European Archives of Psychiatry and Clinical Neuroscience 263, 593606.
Birkhoff, JM, Garberi, C and Re, L (2016) The behavioral variant of frontotemporal dementia: an analysis of the literature and a case report. International Journal of Law and Psychiatry 47, 157163.
Biswal, B, Yetkin, FZ, Haughton, VM and Hyde, JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magnetic Resonance in Medicine 34, 537541.
Bjørnebekk, A, Walhovd, KB, Jørstad, ML, Due-Tønnessen, P, Hullstein, IR and Fjell, AM (2017) Structural brain imaging of long-term anabolic-androgenic steroid users and nonusing weightlifters. Biological Psychiatry 82, 294302.
Blair, RJ (2007) The amygdala and ventromedial prefrontal cortex in morality and psychopathy. Trends in Cognitive Science 11, 387392.
Blair, RJ (2012) Cortical thinning and functional connectivity in psychopathy. The American Journal of Psychiatry 169, 684687.
Blair, RJ, Veroude, K and Buitelaar, JK (2018) Neuro-cognitive system dysfunction and symptom sets: a review of fMRI studies in youth with conduct problems. Neuroscience & Biobehavioral Reviews 91, 6990.
Boccardi, M, Ganzola, R, Rossi, R, Sabattoli, F, Laakso, MP, Repo-Tiihonen, E, Vaurio, O, Könönen, M, Aronen, HJ, Thompson, PM, Frisoni, GB and Tiihonen, J (2010) Abnormal hippocampal shape in offenders with psychopathy. Human Brain Mapping 31, 438447.
Boccardi, M, Frisoni, GB, Hare, RD, Cavedo, E, Najt, P, Pievani, M, Rasser, PE, Laakso, MP, Aronen, HJ, Repo-Tiihonen, E, Vaurio, O, Thompson, PM and Tiihonen, J (2011) Cortex and amygdala morphology in psychopathy. Psychiatry Research 193, 8592.
Boccardi, M, Bocchetta, M, Aronen, HJ, Repo-Tiihonen, E, Vaurio, O, Thompson, PM, Tiihonen, J and Frisoni, GB (2013) Atypical nucleus accumbens morphology in psychopathy: another limbic piece in the puzzle. International Journal of Law and Psychiatry 36, 157167.
Brower, MC and Price, BH (2001) Neuropsychiatry of frontal lobe dysfunction in violent and criminal behaviour: a critical review. Journal of Neurology, Neurosurgery, and Psychiatry 71, 720726.
Busso, DS, McLaughlin, KA, Brueck, S, Peverill, M, Gold, AL and Sheridan, MA (2017) Child abuse, neural structure, and adolescent psychopathology: a longitudinal study. Journal of the American Academy of Child and Adolescent Psychiatry 56, 321328.e1.
Choi, J, Jeong, B, Rohan, ML, Polcari, AM and Teicher, MH (2009) Preliminary evidence for white matter tract abnormalities in young adults exposed to parental verbal abuse. Biological Psychiatry 65, 227234.
Contreras-Rodríguez, O, Pujol, J, Batalla, I, Harrison, BJ, Bosque, J, Ibern-Regàs, I, Hernández-Ribas, R, Soriano-Mas, C, Deus, J, López-Solà, M, Pifarré, J, Menchón, JM and Cardoner, N (2014) Disrupted neural processing of emotional faces in psychopathy. Social Cognitive and Affective Neuroscience 9, 505512.
Contreras-Rodríguez, O, Pujol, J, Batalla, I, Harrison, BJ, Soriano-Mas, C, Deus, J, López-Solà, M, Macià, D, Pera, V, Hernández-Ribas, R, Pifarré, J, Menchón, JM and Cardoner, N (2015) Functional connectivity bias in the prefrontal cortex of psychopaths. Biological Psychiatry 78, 647655.
Cope, LM, Ermer, E, Nyalakanti, PK, Calhoun, VD and Kiehl, KA (2014 a) Paralimbic gray matter reductions in incarcerated adolescent females with psychopathic traits. Journal of Abnormal Child Psychology 42, 659668.
Cope, LM, Vincent, GM, Jobelius, JL, Nyalakanti, PK, Calhoun, VD and Kiehl, KA (2014 b) Psychopathic traits modulate brain responses to drug cues in incarcerated offenders. Frontiers in Human Neuroscience 8, 87.
Craig, MC, Catani, M, Deeley, Q, Latham, R, Daly, E, Kanaan, R, Picchioni, M, McGuire, PK, Fahy, T and Murphy, DG (2009) Altered connections on the road to psychopathy. Molecular Psychiatry 14, 946953.
da Cunha-Bang, S, Hjordt, LV, Perfalk, E, Beliveau, V, Bock, C, Lehel, S, Thomsen, C, Sestoft, D, Svarer, C and Knudsen, GM (2017) Serotonin 1B receptor binding is associated with trait anger and level of psychopathy in violent offenders. Biological Psychiatry 82, 267274.
Darby, RR, Horn, A, Cushman, F and Fox, MD (2018) Lesion network localization of criminal behavior. Proceedings of the National Academy of Sciences of the USA 115, 601606.
De Brito, SA, Mechelli, A, Wilke, M, Laurens, KR, Jones, AP, Barker, GJ, Hodgins, S and Viding, E (2009) Size matters: increased grey matter in boys with conduct problems and callous-unemotional traits. Brain 132, 843852.
De Brito, SA, McCrory, EJ, Mechelli, A, Wilke, M, Jones, AP, Hodgins, S and Viding, E (2011) Small, but not perfectly formed: decreased white matter concentration in boys with psychopathic tendencies. Molecular Psychiatry 16, 476477.
Decety, J, Chen, C, Harenski, C and Kiehl, KA (2013 a) An fMRI study of affective perspective taking in individuals with psychopathy: imagining another in pain does not evoke empathy. Frontiers in Human Neuroscience 7, 489.
Decety, J, Skelly, LR and Kiehl, KA (2013 b) Brain response to empathy-eliciting scenarios involving pain in incarcerated individuals with psychopathy. JAMA Psychiatry 70, 638645.
Decety, J, Skelly, L, Yoder, KJ and Kiehl, KA (2014) Neural processing of dynamic emotional facial expressions in psychopaths. Social Neuroscience 9, 3649.
Decety, J, Chen, C, Harenski, CL and Kiehl, KA (2015) Socioemotional processing of morally-laden behavior and their consequences on others in forensic psychopaths. Human Brain Mapping 36, 20152026.
Deeley, Q, Daly, E, Surguladze, S, Tunstall, N, Mezey, G, Beer, D, Ambikapathy, A, Robertson, D, Giampietro, V, Brammer, MJ, Clarke, A, Dowsett, J, Fahy, T, Phillips, ML and Murphy, DG (2006) Facial emotion processing in criminal psychopathy. Preliminary functional magnetic resonance imaging study. The British Journal of Psychiatry 189, 533539.
de Oliveira-Souza, R, Hare, RD, Bramati, IE, Garrido, GJ, Azevedo Ignácio, F, Tovar-Moll, F and Moll, J (2008) Psychopathy as a disorder of the moral brain: fronto-temporo-limbic grey matter reductions demonstrated by voxel-based morphometry. Neuroimage 40, 12021213.
Diehl-Schmid, J, Perneczky, R, Koch, J, Nedopil, N and Kurz, A (2013) Guilty by suspicion? Criminal behavior in frontotemporal lobar degeneration. Cognitive and Behavioral Neurology 26, 7377.
Dolan, MC, Deakin, JF, Roberts, N and Anderson, IM (2002) Quantitative frontal and temporal structural MRI studies in personality-disordered offenders and control subjects. Psychiatry Research 116, 133149.
Douaud, G, Jbabdi, S, Behrens, TE, Menke, RA, Gass, A, Monsch, AU, Rao, A, Whitcher, B, Kindlmann, G, Matthews, PM and Smith, S (2011) DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease. Neuroimage 55, 880890.
Ermer, E, Cope, LM, Nyalakanti, PK, Calhoun, VD and Kiehl, KA (2012) Aberrant paralimbic gray matter in criminal psychopathy. Journal of Abnormal Psychology 121, 649658.
Ermer, E, Cope, LM, Nyalakanti, PK, Calhoun, VD and Kiehl, KA (2013) Aberrant paralimbic gray matter in incarcerated male adolescents with psychopathic traits. Journal of the American Academy of Child and Adolescent Psychiatry 52, 94103.e3.
Fair, DA, Cohen, AL, Power, JD, Dosenbach, NU, Church, JA, Miezin, FM, Schlaggar, BL and Petersen, SE (2009) Functional brain networks develop from a ‘local to distributed’ organization. PLoS Computational Biology 5, e1000381.
Fairchild, G, Hagan, CC, Walsh, ND, Passamonti, L, Calder, AJ and Goodyer, IM (2013) Brain structure abnormalities in adolescent girls with conduct disorder. Journal of Child Psychology and Psychiatry 54, 8695.
Freeman, SM, Clewett, DV, Bennett, CM, Kiehl, KA, Gazzaniga, MS and Miller, MB (2015) The posteromedial region of the default mode network shows attenuated task-induced deactivation in psychopathic prisoners. Neuropsychology 29, 493500.
Geurts, DE, von Borries, K, Volman, I, Bulten, BH, Cools, R and Verkes, RJ (2016) Neural connectivity during reward expectation dissociates psychopathic criminals from non-criminal individuals with high impulsive/antisocial psychopathic traits. Social Cognitive and Affective Neuroscience 11, 13261334.
Glenn, AL, Raine, A and Schug, RA (2009) The neural correlates of moral decision-making in psychopathy. Molecular Psychiatry 14, 56.
Glenn, AL, Yang, Y, Raine, A and Colletti, P (2010 a) No volumetric differences in the anterior cingulate of psychopathic individuals. Psychiatry Research 183, 140143.
Glenn, AL, Raine, A, Yaralian, PS and Yang, Y (2010 b) Increased volume of the striatum in psychopathic individuals. Biological Psychiatry 67, 5258.
Greene, JD, Sommerville, RB, Nystrom, LE, Darley, JM and Cohen, JD (2001) An fMRI investigation of emotional engagement in moral judgment. Science 293, 21052108.
Gregory, S, ffytche, D, Simmons, A, Kumari, V, Howard, M, Hodgins, S and Blackwood, N (2012) The antisocial brain: psychopathy matters. Archives of General Psychiatry 69, 962972.
Gregory, S, Blair, RJ, Ffytche, D, Simmons, A, Kumari, V, Hodgins, S and Blackwood, N (2015) Punishment and psychopathy: a case-control functional MRI investigation of reinforcement learning in violent antisocial personality disordered men. The Lancet. Psychiatry 2 153160.
Hare, RD (2003) Hare Psychopathy Checklist- Revised (PCL-R), 2nd Edn. Toronto: Multi-Health Systems Inc.
Harenski, CL, Harenski, KA, Shane, MS and Kiehl, KA (2010) Aberrant neural processing of moral violations in criminal psychopaths. Journal of Abnormal Psychology 119, 863874.
Harenski, CL, Harenski, KA and Kiehl, KA (2014) Neural processing of moral violations among incarcerated adolescents with psychopathic traits. Developmental Cognitive Neuroscience 10, 181189.
Harrison, BJ, Pujol, J, López-Solà, M, Hernández-Ribas, R, Deus, J, Ortiz, H, Soriano-Mas, C, Yücel, M, Pantelis, C and Cardoner, N (2008) Consistency and functional specialization in the default mode brain network. Proceedings of the National Academy of Sciences of the USA 105, 97819786.
Heany, SJ, van Honk, J, Stein, DJ and Brooks, SJ (2016) A quantitative and qualitative review of the effects of testosterone on the function and structure of the human social-emotional brain. Metabolic Brain Disease 31, 157167.
Holz, NE, Boecker, R, Hohm, E, Zohsel, K, Buchmann, AF, Blomeyer, D, Barker, G, Bokde, AL, Bromberg, U, Büchel, C, Cattrell, A, Conrod, PJ, Desrivières, S, Flor, H, Frouin, V, Gallinat, J, Gowland, P, Heinz, A, Ittermann, B, Paillère Martinot, ML, Artiges, E, Nees, F, Papadopoulos-Orfanos, D, Poustka, L, Smolka, MN, Jurk, S, Walter, H, Whelan, R, Schumann, G, Althoff, RR, Garavan, H and IMAGEN Consortium (2015) The long-term impact of early life poverty on orbitofrontal cortex volume in adulthood: results from a prospective study over 25 years. Neuropsychopharmacology 40, 9961004.
Hoppenbrouwers, SS, Nazeri, A, de Jesus, DR, Stirpe, T, Felsky, D, Schutter, DJ, Daskalakis, ZJ and Voineskos, AN (2013) White matter deficits in psychopathic offenders and correlation with factor structure. PLoS One 8, e72375.
Hyde, LW, Byrd, AL, Votruba-Drzal, E, Hariri, AR and Manuck, SB (2014) Amygdala reactivity and negative emotionality: divergent correlates of antisocial personality and psychopathy traits in a community sample. Journal of Abnormal Psychology 123, 214224.
Intrator, J, Hare, R, Stritzke, P, Brichtswein, K, Dorfman, D, Harpur, T, Bernstein, D, Handelsman, L, Schaefer, C, Keilp, J, Rosen, J and Machac, J (1997) A brain imaging (single photon emission computerized tomography) study of semantic and affective processing in psychopaths. Biological Psychiatry 42, 96103.
Jeong, W, Chung, CK and Kim, JS (2015) Episodic memory in aspects of large-scale brain networks. Frontiers in Human Neuroscience 9, 454.
Jiang, W, Li, G, Liu, H, Shi, F, Wang, T, Shen, C, Lee, SW, Hu, D, Wang, W and Shen, D (2016) Reduced cortical thickness and increased surface area in antisocial personality disorder. Neuroscience 337, 143152.
Jiang, W, Shi, F, Liao, J, Liu, H, Wang, T, Shen, C, Hu, D, Wang, W and Shen, D (2017 a) Disrupted functional connectome in antisocial personality disorder. Brain Imaging and Behavior 11, 10711084.
Jiang, W, Shi, F, Liu, H, Li, G, Ding, Z, Shen, H, Lee, SW, Hu, D, Wang, W and Shen, D (2017 b) Reduced white matter integrity in antisocial personality disorder: a diffusion tensor imaging study. Scientific Reports 7, 43002.
Jones, DK, Knösche, TR and Turner, R (2013) White matter integrity, fiber count, and other fallacies: the do's and don'ts of diffusion MRI. Neuroimage 73: 239254.
Juárez, M, Kiehl, KA and Calhoun, VD (2013) Intrinsic limbic and paralimbic networks are associated with criminal psychopathy. Human Brain Mapping 34, 19211930.
Kiehl, KA and Hoffman, MB (2011) The criminal psychopath: history, neuroscience, treatment, and economics. Jurimetrics 51, 355397.
Kiehl, KA, Smith, AM, Hare, RD, Mendrek, A, Forster, BB, Brink, J and Liddle, PF (2001) Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biological Psychiatry 50, 677684.
Koenigs, M, Young, L, Adolphs, R, Tranel, D, Cushman, F, Hauser, M and Damasio, A (2007) Damage to the prefrontal cortex increases utilitarian moral judgements. Nature 446, 908911.
Kolla, NJ, Gregory, S, Attard, S, Blackwood, N and Hodgins, S (2014) Disentangling possible effects of childhood physical abuse on gray matter changes in violent offenders with psychopathy. Psychiatry Research 221, 123126.
Kolla, NJ, Matthews, B, Wilson, AA, Houle, S, Bagby, RM, Links, P, Simpson, AI, Hussain, A and Meyer, JH (2015) Lower monoamine oxidase-A total distribution volume in impulsive and violent male offenders with antisocial personality disorder and high psychopathic traits: an [(11)C] harmine positron emission tomography study. Neuropsychopharmacology 40, 25962603.
Korponay, C, Pujara, M, Deming, P, Philippi, C, Decety, J, Kosson, DS, Kiehl, KA and Koenigs, M (2017 a) Impulsive-antisocial psychopathic traits linked to increased volume and functional connectivity within prefrontal cortex. Social Cognitive and Affective Neuroscience 12, 11691178.
Korponay, C, Pujara, M, Deming, P, Philippi, C, Decety, J, Kosson, DS, Kiehl, KA and Koenigs, M (2017 b) Impulsive-antisocial dimension of psychopathy linked to enlargement and abnormal functional connectivity of the striatum. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2, 149157.
Kumari, V, Uddin, S, Premkumar, P, Young, S, Gudjonsson, GH, Raghuvanshi, S, Barkataki, I, Sumich, A, Taylor, P and Das, M (2014) Lower anterior cingulate volume in seriously violent men with antisocial personality disorder or schizophrenia and a history of childhood abuse. Australian and New Zealand Journal of Psychiatry 48, 153161.
Laakso, MP, Vaurio, O, Koivisto, E, Savolainen, L, Eronen, M, Aronen, HJ, Hakola, P, Repo, E, Soininen, H and Tiihonen, J (2001) Psychopathy and the posterior hippocampus. Behavioural Brain Research 118, 187193.
Laakso, MP, Gunning-Dixon, F, Vaurio, O, Repo-Tiihonen, E, Soininen, H and Tiihonen, J (2002) Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism. Psychiatry Research 114, 95102.
Lamsma, J, Mackay, C and Fazel, S (2017) Structural brain correlates of interpersonal violence: systematic review and voxel-based meta-analysis of neuroimaging studies. Psychiatry Research, Neuroimaging 267, 6973.
Larson, CL, Baskin-Sommers, AR, Stout, DM, Balderston, NL, Curtin, JJ, Schultz, DH, Kiehl, KA and Newman, JP (2013) The interplay of attention and emotion: top-down attention modulates amygdala activation in psychopathy. Cognitive, Affective, & Behavioral Neuroscience 13, 757770.
Lebel, C, Gee, M, Camicioli, R, Wieler, M, Martin, W and Beaulieu, C (2012) Diffusion tensor imaging of white matter tract evolution over the lifespan. Neuroimage 60, 340352.
Leech, R and Sharp, DJ (2014) The role of the posterior cingulate cortex in cognition and disease. Brain 137, 1232.
Lilienfeld, SO and Andrews, BP (1996) Development and preliminary validation of a self-report measure of psychopathic personality traits in noncriminal populations. Journal of Personality Assessment 66, 488524.
Ly, M, Motzkin, JC, Philippi, CL, Kirk, GR, Newman, JP, Kiehl, KA and Koenigs, M (2012) Cortical thinning in psychopathy. The American Journal of Psychiatry 169, 743749.
Mackey, S, Chaarani, B, Kan, KJ, Spechler, PA, Orr, C, Banaschewski, T, Barker, G, Bokde, AL, Bromberg, U, Büchel, C, Cattrell, A, Conrod, PJ, Desrivières, S, Flor, H, Frouin, V, Gallinat, J, Gowland, P, Heinz, A, Ittermann, B, Paillère Martinot, ML, Artiges, E, Nees, F, Papadopoulos-Orfanos, D, Poustka, L, Smolka, MN, Jurk, S, Walter, H, Whelan, R, Schumann, G, Althoff, RR, Garavan, H and IMAGEN Consortium (2017) Brain regions related to impulsivity mediate the effects of early adversity on antisocial behavior. Biological Psychiatry 82, 275282.
Marsh, AA and Cardinale, EM (2014) When psychopathy impairs moral judgments: neural responses during judgments about causing fear. Social Cognitive and Affective Neuroscience 9, 311.
Matochik, JA, Eldreth, DA, Cadet, JL and Bolla, KI (2005) Altered brain tissue composition in heavy marijuana users. Drug and Alcohol Dependence 77, 2330.
McKenzie, IA, Ohayon, D, Li, H, de Faria, JP, Emery, B, Tohyama, K and Richardson, WD (2014) Motor skill learning requires active central myelination. Science 346, 318322.
Meffert, H, Gazzola, V, den Boer, JA, Bartels, AA and Keysers, C (2013) Reduced spontaneous but relatively normal deliberate vicarious representations in psychopathy. Brain 136, 25502562.
Mier, D, Haddad, L, Diers, K, Dressing, H, Meyer-Lindenberg, A and Kirsch, P (2014) Reduced embodied simulation in psychopathy. The World Journal of Biological Psychiatry 15, 479487.
Moll, J, de Oliveira-Souza, R, Garrido, GJ, Bramati, IE, Caparelli-Daquer, EM, Paiva, ML, Zahn, R and Grafman, J (2007) The self as a moral agent: linking the neural bases of social agency and moral sensitivity. Social Neuroscience 2, 336352.
Moll, J, De Oliveira-Souza, R and Zahn, R (2008) The neural basis of moral cognition: sentiments, concepts, and values. Annals of the New York Academy of Sciences 1124, 161180.
Motzkin, JC, Newman, JP, Kiehl, KA and Koenigs, M (2011) Reduced prefrontal connectivity in psychopathy. Journal of Neuroscience 31, 1734817357.
Müller, JL, Sommer, M, Wagner, V, Lange, K, Taschler, H, Röder, CH, Schuierer, G, Klein, HE and Hajak, G (2003) Abnormalities in emotion processing within cortical and subcortical regions in criminal psychopaths: evidence from a functional magnetic resonance imaging study using pictures with emotional content. Biological Psychiatry 54, 152162.
Müller, JL, Gänssbauer, S, Sommer, M, Döhnel, K, Weber, T, Schmidt-Wilcke, T and Hajak, G (2008) Gray matter changes in right superior temporal gyrus in criminal psychopaths. Evidence from voxel-based morphometry. Psychiatry Research 163, 213222.
Narayan, VM, Narr, KL, Kumari, V, Woods, RP, Thompson, PM, Toga, AW and Sharma, T (2007) Regional cortical thinning in subjects with violent antisocial personality disorder or schizophrenia. The American Journal of Psychiatry 164, 14181427.
Newman, JP and Baskin-Sommers, AR (2016) Smith and Lilienfeld's meta-analysis of the response modulation hypothesis: important theoretical and quantitative clarifications. Psychological Bulletin 142, 13841393.
Newman, JP, Curtin, JJ, Bertsch, JD and Baskin-Sommers, AR (2010) Attention moderates the fearlessness of psychopathic offenders. Biological Psychiatry 67, 6670.
Noordermeer, SD, Luman, M and Oosterlaan, J (2016) A systematic review and meta-analysis of neuroimaging in Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) taking Attention-Deficit Hyperactivity Disorder (ADHD) into account. Neuropsychology Review 26, 4472.
Ou, X, Andres, A, Pivik, RT, Cleves, MA and Badger, TM (2015) Brain gray and white matter differences in healthy normal weight and obese children. Journal of Magnetic Resonance Imaging 42, 12051213.
Patrick, CJ (2014) Physiological correlates of psychopathy, antisocial personality disorder, habitual aggression, and violence. Current Topics in Behavioral Neurosciences 21, 197227.
Patrick, CJ, Fowles, DC and Krueger, RF (2009) Triarchic conceptualization of psychopathy: developmental origins of disinhibition, boldness, and meanness. Development and Psychopathology 21, 913938.
Paus, T, Collins, DL, Evans, AC, Leonard, G, Pike, B and Zijdenbos, A (2001) Maturation of white matter in the human brain: a review of magnetic resonance studies. Brain Research Bulletin 54, 255266.
Pera-Guardiola, V, Contreras-Rodríguez, O, Batalla, I, Kosson, D, Menchón, JM, Pifarré, J, Bosque, J, Cardoner, N and Soriano-Mas, C (2016) Brain structural correlates of emotion recognition in psychopaths. PLoS One 11, e0149807.
Philippi, CL, Pujara, MS, Motzkin, JC, Newman, J, Kiehl, KA and Koenigs, M (2015) Altered resting-state functional connectivity in cortical networks in psychopathy. Journal of Neuroscience 35, 60686078.
Prehn, K, Schlagenhauf, F, Schulze, L, Berger, C, Vohs, K, Fleischer, M, Hauenstein, K, Keiper, P, Domes, G and Herpertz, SC (2013) Neural correlates of risk taking in violent criminal offenders characterized by emotional hypo- and hyper-reactivity. Social Neuroscience 8, 136147.
Pujara, M, Motzkin, JC, Newman, JP, Kiehl, KA and Koenigs, M (2014) Neural correlates of reward and loss sensitivity in psychopathy. Social Cognitive and Affective Neuroscience 9, 794801.
Pujol, J, Vendrell, P, Junqué, C, Martí-Vilalta, JL and Capdevila, A (1993) When does human brain development end? Evidence of corpus callosum growth up to adulthood. Annals of Neurology 34, 7175.
Pujol, J, Soriano-Mas, C, Ortiz, H, Sebastián-Gallés, N, Losilla, JM and Deus, J (2006) Myelination of language-related areas in the developing brain. Neurology 66, 339343.
Pujol, J, Batalla, I, Contreras-Rodríguez, O, Harrison, BJ, Pera, V, Hernández-Ribas, R, Real, E, Bosa, L, Soriano-Mas, C, Deus, J, López-Solà, M, Pifarré, J, Menchón, JM and Cardoner, N (2012) Breakdown in the brain network subserving moral judgment in criminal psychopathy. Social Cognitive and Affective Neuroscience 7, 917923.
Pujol, J, Fenoll, R, Forns, J, Harrison, BJ, Martínez-Vilavella, G, Macià, D, Alvarez-Pedrerol, M, Blanco-Hinojo, L, González-Ortiz, S, Deus, J and Sunyer, J (2016 a) Video gaming in school children: how much is enough? Annals of Neurology 80, 424433.
Pujol, J, Martínez-Vilavella, G, Macià, D, Fenoll, R, Alvarez-Pedrerol, M, Rivas, I, Forns, J, Blanco-Hinojo, L, Capellades, J, Querol, X, Deus, J and Sunyer, J (2016 b) Traffic pollution exposure is associated with altered brain connectivity in school children. Neuroimage 129, 175184.
Raine, A and Yang, Y (2006) Neural foundations to moral reasoning and antisocial behavior. Social Cognitive and Affective Neuroscience 1, 203213.
Raine, A, Buchsbaum, M and LaCasse, L (1997) Brain abnormalities in murderers indicated by positron emission tomography. Biological Psychiatry 42, 495508.
Raine, A, Lencz, T, Bihrle, S, LaCasse, L and Colletti, P (2000) Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. Archives of General Psychiatry 57, 119127.
Raine, A, Lencz, T, Taylor, K, Hellige, JB, Bihrle, S, Lacasse, L, Lee, M, Ishikawa, S and Colletti, P (2003) Corpus callosum abnormalities in psychopathic antisocial individuals. Archives of General Psychiatry 60, 11341142.
Raine, A, Ishikawa, SS, Arce, E, Lencz, T, Knuth, KH, Bihrle, S, LaCasse, L and Colletti, P (2004) Hippocampal structural asymmetry in unsuccessful psychopaths. Biological Psychiatry 55, 185191.
Raine, A, Lee, L, Yang, Y and Colletti, P (2010) Neurodevelopmental marker for limbic maldevelopment in antisocial personality disorder and psychopathy. The British Journal of Psychiatry 197, 186192.
Raine, A, Yang, Y, Narr, KL and Toga, AW (2011) Sex differences in orbitofrontal gray as a partial explanation for sex differences in antisocial personality. Molecular Psychiatry 16, 227236.
Rodman, AM, Kastman, E, Dorfman, HM, Baskin-Sommers, A, Kiehl, KA, Newman, JP and Buckholtz, JW (2016) Selective mapping of psychopathy and externalizing to dissociable circuits for inhibitory self-control. Clinical Psychological Science 4, 559571.
Rogers, JC and De Brito, SA (2016) Cortical and subcortical gray matter volume in youths with conduct problems: a meta-analysis. JAMA Psychiatry 73, 6472.
Saba, L, Anzidei, M, Raz, E, Suri, J, Piga, M, Grassi, R and Catalano, C (2013) MR and CT of brain's cava. Journal of Neuroimaging 23, 326335.
Sato, SM, Schulz, KM, Sisk, CL and Wood, RI (2008) Adolescents and androgens, receptors and rewards. Hormones and Behavior 53, 647658.
Sato, JR, de Oliveira-Souza, R, Thomaz, CE, Basílio, R, Bramati, IE, Amaro, E Jr., Tovar-Moll, F, Hare, RD and Moll, J (2011) Identification of psychopathic individuals using pattern classification of MRI images. Social Neuroscience 6, 627639.
Schneider, F, Habel, U, Kessler, C, Posse, S, Grodd, W and Müller-Gärtner, HW (2000) Functional imaging of conditioned aversive emotional responses in antisocial personality disorder. Neuropsychobiology 42, 192201.
Schultz, DH, Balderston, NL, Baskin-Sommers, AR, Larson, CL and Helmstetter, FJ (2016) Psychopaths show enhanced amygdala activation during fear conditioning. Frontiers in Psychology 7, 348.
Sethi, A, Gregory, S, Dell'Acqua, F, Periche Thomas, E, Simmons, A, Murphy, DG, Hodgins, S, Blackwood, NJ and Craig, MC (2015) Emotional detachment in psychopathy: involvement of dorsal default-mode connections. Cortex 62, 1119.
Sherman, LE, Rudie, JD, Pfeifer, JH, Masten, CL, McNealy, K and Dapretto, M (2014) Development of the default mode and central executive networks across early adolescence: a longitudinal study. Developmental Cognitive Neuroscience 10, 148159.
Simpson, EH and Balsam, PD (2016) Behavioral Neuroscience of Motivation. Switzerland: Springer International Publishing.
Sitaram, R, Caria, A, Veit, R, Gaber, T, Ruiz, S and Birbaumer, N (2014) Volitional control of the anterior insula in criminal psychopaths using real-time fMRI neurofeedback: a pilot study. Frontiers in Behavioral Neuroscience 8, 344.
Soderstrom, H, Hultin, L, Tullberg, M, Wikkelso, C, Ekholm, S and Forsman, A (2002) Reduced frontotemporal perfusion in psychopathic personality. Psychiatry Research 114, 8194.
Sommer, M, Sodian, B, Döhnel, K, Schwerdtner, J, Meinhardt, J and Hajak, G (2010) In psychopathic patients emotion attribution modulates activity in outcome-related brain areas. Psychiatry Research 182, 8895.
Soriano-Mas, C, Hernández-Ribas, R, Pujol, J, Urretavizcaya, M, Deus, J, Harrison, BJ, Ortiz, H, López-Solà, M, Menchón, JM and Cardoner, N (2011) Cross-sectional and longitudinal assessment of structural brain alterations in melancholic depression. Biological Psychiatry 69, 318325.
Sundram, F, Deeley, Q, Sarkar, S, Daly, E, Latham, R, Craig, M, Raczek, M, Fahy, T, Picchioni, M, UK AIMS Network, Barker, GJ and Murphy, DG (2012) White matter microstructural abnormalities in the frontal lobe of adults with antisocial personality disorder. Cortex 48, 216229.
Tang, Y, Long, J, Wang, W, Liao, J, Xie, H, Zhao, G and Zhang, H (2016) Aberrant functional brain connectome in people with antisocial personality disorder. Scientific Reports 6, 26209.
Tiihonen, J, Rossi, R, Laakso, MP, Hodgins, S, Testa, C, Perez, J, Repo-Tiihonen, E, Vaurio, O, Soininen, H, Aronen, HJ, Könönen, M, Thompson, PM and Frisoni, GB (2008) Brain anatomy of persistent violent offenders: more rather than less. Psychiatry Research 163, 201212.
Toivonen, P, Könönen, M, Niskanen, E, Vaurio, O, Repo-Tiihonen, E, Seppänen, A, Aronen, HJ, Vanninen, R, Tiihonen, J and Laakso, MP (2013) Cavum septum pellucidum and psychopathy. The British Journal of Psychiatry 203, 152153.
Veit, R, Flor, H, Erb, M, Hermann, C, Lotze, M, Grodd, W and Birbaumer, N (2002) Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neuroscience Letters 328, 233236.
Veit, R, Lotze, M, Sewing, S, Missenhardt, H, Gaber, T and Birbaumer, N (2010) Aberrant social and cerebral responding in a competitive reaction time paradigm in criminal psychopaths. Neuroimage 49, 33653372.
Venables, NC, Hall, JR and Patrick, CJ (2014) Differentiating psychopathy from antisocial personality disorder: a triarchic model perspective. Psychological Medicine 44, 10051013.
Veroude, K, von Rhein, D, Chauvin, RJ, van Dongen, EV, Mennes, MJ, Franke, B, Heslenfeld, DJ, Oosterlaan, J, Hartman, CA, Hoekstra, PJ, Glennon, JC and Buitelaar, JK (2016) The link between callous-unemotional traits and neural mechanisms of reward processing: an fMRI study. Psychiatry Research 255, 7580.
Volkow, ND, Tancredi, LR, Grant, C, Gillespie, H, Valentine, A, Mullani, N, Wang, GJ and Hollister, L (1995) Brain glucose metabolism in violent psychiatric patients: a preliminary study. Psychiatry Research 61, 243253.
Volman, I, von Borries, AK, Bulten, BH, Verkes, RJ, Toni, I and Roelofs, K (2016) Testosterone modulates altered prefrontal control of emotional actions in psychopathic offenders. eNeuro 3, pii, ENEURO.0107-15.2016.
Waller, R, Dotterer, HL, Murray, L, Maxwell, AM and Hyde, LW (2017) White-matter tract abnormalities and antisocial behavior: a systematic review of diffusion tensor imaging studies across development. Neuroimage Clinical 14, 201215.
Walters, GD, Ermer, E, Knight, RA and Kiehl, KA (2015) Paralimbic biomarkers in taxometric analyses of psychopathy: does changing the indicators change the conclusion? Personality Disorders 6, 4152.
White, SF, Brislin, S, Sinclair, S, Fowler, KA, Pope, K and Blair, RJ (2013) The relationship between large cavum septum pellucidum and antisocial behavior, callous-unemotional traits and psychopathy in adolescents. Journal of Child Psychology and Psychiatry 54, 575581.
Wolf, RC, Pujara, MS, Motzkin, JC, Newman, JP, Kiehl, KA, Decety, J, Kosson, DS and Koenigs, M (2015) Interpersonal traits of psychopathy linked to reduced integrity of the uncinate fasciculus. Human Brain Mapping 36, 42024209.
Yakovlev, PI and LeCours, AR (1967): The myelogenetic cycles of regional maturation of the brain. In Minkowski, A (ed.), Regional Development of the Brain in Early Life. Oxford: Blackwell, pp. 370.
Yang, Y and Raine, A (2009) Prefrontal structural and functional brain imaging findings in antisocial, violent, and psychopathic individuals: a meta-analysis. Psychiatry Research 174, 8188.
Yang, Y, Raine, A, Lencz, T, Bihrle, S, LaCasse, L and Colletti, P (2005 a) Volume reduction in prefrontal gray matter in unsuccessful criminal psychopaths. Biological Psychiatry 57, 11031108.
Yang, Y, Raine, A, Lencz, T, Bihrle, S, Lacasse, L and Colletti, P (2005 b) Prefrontal white matter in pathological liars. The British Journal of Psychiatry 187, 320325.
Yang, Y, Raine, A, Colletti, P, Toga, AW and Narr, KL (2009 a) Abnormal temporal and prefrontal cortical gray matter thinning in psychopaths. Molecular Psychiatry 14, 561562.
Yang, Y, Raine, A, Narr, KL, Colletti, P and Toga, AW (2009 b) Localization of deformations within the amygdala in individuals with psychopathy. Archives of General Psychiatry 66, 986994.
Yang, Y, Raine, A, Colletti, P, Toga, AW and Narr, KL (2010) Morphological alterations in the prefrontal cortex and the amygdala in unsuccessful psychopaths. Journal of Abnormal Psychology 119, 546554.
Yang, Y, Raine, A, Joshi, AA, Joshi, S, Chang, YT, Schug, RA, Wheland, D, Leahy, R and Narr, KL (2012) Frontal information flow and connectivity in psychopathy. The British Journal of Psychiatry 201, 408409.
Yildirim, BO and Derksen, JJ (2012) A review on the relationship between testosterone and life-course persistent antisocial behavior. Psychiatry Research 200, 9841010.
Yoder, KJ, Harenski, C, Kiehl, KA and Decety, J (2015) Neural networks underlying implicit and explicit moral evaluations in psychopathy. Translational Psychiatry 5, e625.
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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
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