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Defective genetic control of sodium-pump density in manic depressive psychosis

Published online by Cambridge University Press:  09 July 2009

Graham J. Naylor  and
Anne H. W. Smith
Graham J. Naylor*
Affiliation:
Department of Psychiatry, The University, Dundee
Anne H. W. Smith
Affiliation:
Department of Psychiatry, The University, Dundee
*
1Address for correspondence: Dr G. J. Naylor, Department of Psychiatry, Ninewells Hospital and Medical School, Dundee DD1 9SY.
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Synopsis

The ability of lymphocytes from manic-depressive and normal subjects to produce new pump sites in response to increased cell sodium was compared in a series of experiments. Ethacrynate or different potassium concentrations were used to increase cell sodium concentration. The lymphocytes of manic depressives had a significantly reduced ability to produce new pump sites. It is suggested that this may be the genetic defect underlying manic depressive psychosis.

Type
Research Article
Information
Psychological Medicine , Volume 11 , Issue 2 , May 1981 , pp. 257 - 263
Copyright
Copyright © Cambridge University Press 1981

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