Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 17
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Cao, Jun Chen, Xiaorong Chen, Jianmei Ai, Ming Gan, Yao Wang, Wo Lv, Zhen Zhang, Shuang Zhang, Shudong Wang, Suya Kuang, Li and Fang, Weidong 2016. Resting-state functional MRI of abnormal baseline brain activity in young depressed patients with and without suicidal behavior. Journal of Affective Disorders, Vol. 205, p. 252.


    de Cates, Angharad N. and Broome, Matthew R. 2016. Can We Use Neurocognition to Predict Repetition of Self-Harm, and Why Might This Be Clinically Useful? A Perspective. Frontiers in Psychiatry, Vol. 7,


    Fekih-Romdhane, Feten Chennoufi, Leila and Cheour, Mejda 2016. Les terroristes suicidaires : qui sont-ils ?. Annales Médico-psychologiques, revue psychiatrique, Vol. 174, Issue. 4, p. 274.


    Iorfino, Frank Hickie, Ian B. Lee, Rico S. C. Lagopoulos, Jim and Hermens, Daniel F. 2016. The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: a systematic review. BMC Psychiatry, Vol. 16, Issue. 1,


    Kerestes, Rebecca Segreti, Anna Maria Pan, Lisa A. Phillips, Mary L. Birmaher, Boris Brent, David A. and Ladouceur, Cecile D. 2016. Altered neural function to happy faces in adolescents with and at risk for depression. Journal of Affective Disorders, Vol. 192, p. 143.


    Sánchez-Loyo, Luis Ventura-Martínez, Eva and González-Garrido, Andrés Antonio 2016. Decision Making in Social Context in Patients with Suicide Attempt History. Suicide and Life-Threatening Behavior, p. n/a.


    Seymour, Karen E. Jones, Richard N. Cushman, Grace K. Galvan, Thania Puzia, Megan E. Kim, Kerri L. Spirito, Anthony and Dickstein, Daniel P. 2016. Emotional face recognition in adolescent suicide attempters and adolescents engaging in non-suicidal self-injury. European Child & Adolescent Psychiatry, Vol. 25, Issue. 3, p. 247.


    Silvers, Jennifer A. Hubbard, Alexa D. Chaudhury, Sadia Biggs, Emily Shu, Jocelyn Grunebaum, Michael F. Fertuck, Eric Weber, Jochen Kober, Hedy Carson-Wong, Amanda Brodsky, Beth S. Chesin, Megan Ochsner, Kevin N. and Stanley, Barbara 2016. Suicide attempters with Borderline Personality Disorder show differential orbitofrontal and parietal recruitment when reflecting on aversive memories. Journal of Psychiatric Research, Vol. 81, p. 71.


    Yaseen, Zimri S. Galynker, Igor I. Briggs, Jessica Freed, Rachel D. and Gabbay, Vilma 2016. Functional domains as correlates of suicidality among psychiatric inpatients. Journal of Affective Disorders, Vol. 203, p. 77.


    Martin, Petra C. Zimmer, Thomas J. and Pan, Lisa A. 2015. Magnetic resonance imaging markers of suicide attempt and suicide risk in adolescents. CNS Spectrums, Vol. 20, Issue. 04, p. 355.


    Minzenberg, Michael J. Lesh, Tyler A. Niendam, Tara A. Yoon, Jong H. Cheng, Yaoan Rhoades, Remy N. and Carter, Cameron S. 2015. Control-related frontal-striatal function is associated with past suicidal ideation and behavior in patients with recent-onset psychotic major mood disorders. Journal of Affective Disorders, Vol. 188, p. 202.


    Radaelli, D. Sferrazza Papa, G. Vai, B. Poletti, S. Smeraldi, E. Colombo, C. and Benedetti, F. 2015. Fronto-limbic disconnection in bipolar disorder. European Psychiatry, Vol. 30, Issue. 1, p. 82.


    Vanyukov, Polina M. Szanto, Katalin Siegle, Greg J. Hallquist, Michael N. Reynolds, Charles F. Aizenstein, Howard J. and Dombrovski, Alexandre Y. 2015. Impulsive Traits and Unplanned Suicide Attempts Predict Exaggerated Prefrontal Response to Angry Faces in the Elderly. The American Journal of Geriatric Psychiatry, Vol. 23, Issue. 8, p. 829.


    Cox Lippard, Elizabeth T. Johnston, Jennifer A.Y. and Blumberg, Hilary P. 2014. Neurobiological Risk Factors for Suicide. American Journal of Preventive Medicine, Vol. 47, Issue. 3, p. S152.


    van Heeringen, Kees and Mann, J John 2014. The neurobiology of suicide. The Lancet Psychiatry, Vol. 1, Issue. 1, p. 63.


    van Heeringen, Kees Bijttebier, Stijn Desmyter, Stefanie Vervaet, Myriam and Baeken, Chris 2014. Is there a neuroanatomical basis of the vulnerability to suicidal behavior? A coordinate-based meta-analysis of structural and functional MRI studies. Frontiers in Human Neuroscience, Vol. 8,


    Zhang, Huawei Chen, Ziqi Jia, Zhiyun and Gong, Qiyong 2014. Dysfunction of neural circuitry in depressive patients with suicidal behaviors: A review of structural and functional neuroimaging studies. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 53, p. 61.


    ×

Differential patterns of activity and functional connectivity in emotion processing neural circuitry to angry and happy faces in adolescents with and without suicide attempt

  • L. A. Pan (a1), S. Hassel (a2), A. M. Segreti (a1), S. A. Nau (a1), D. A. Brent (a1) and M. L. Phillips (a1) (a3)
  • DOI: http://dx.doi.org/10.1017/S0033291712002966
  • Published online: 09 January 2013
Abstract
Background

Neural substrates of emotion dysregulation in adolescent suicide attempters remain unexamined.

Method

We used functional magnetic resonance imaging to measure neural activity to neutral, mild or intense (i.e. 0%, 50% or 100% intensity) emotion face morphs in two separate emotion-processing runs (angry and happy) in three adolescent groups: (1) history of suicide attempt and depression (ATT, n = 14); (2) history of depression alone (NAT, n = 15); and (3) healthy controls (HC, n = 15). Post-hoc analyses were conducted on interactions from 3 group × 3 condition (intensities) whole-brain analyses (p < 0.05, corrected) for each emotion run.

Results

To 50% intensity angry faces, ATT showed significantly greater activity than NAT in anterior cingulate gyral–dorsolateral prefrontal cortical attentional control circuitry, primary sensory and temporal cortices; and significantly greater activity than HC in the primary sensory cortex, while NAT had significantly lower activity than HC in the anterior cingulate gyrus and ventromedial prefrontal cortex. To neutral faces during the angry emotion-processing run, ATT had significantly lower activity than NAT in the fusiform gyrus. ATT also showed significantly lower activity than HC to 100% intensity happy faces in the primary sensory cortex, and to neutral faces in the happy run in the anterior cingulate and left medial frontal gyri (all p < 0.006,corrected). Psychophysiological interaction analyses revealed significantly reduced anterior cingulate gyral–insula functional connectivity to 50% intensity angry faces in ATT v. NAT or HC.

Conclusions

Elevated activity in attention control circuitry, and reduced anterior cingulate gyral–insula functional connectivity, to 50% intensity angry faces in ATT than other groups suggest that ATT may show inefficient recruitment of attentional control neural circuitry when regulating attention to mild intensity angry faces, which may represent a potential biological marker for suicide risk.

Copyright
Corresponding author
*Address for correspondence: L. A. Pan, M.D., Assistant Professor of Psychiatry, Child and Adolescent Psychiatry, Loeffler Building, 121 Meyran Avenue, Room 304, Pittsburgh, PA 15213, USA. (Email: thomasla@upmc.edu)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

A Anand , Y Li , Y Wang , J Wu , S Gao , L Bukhari , VP Mathews , A Kalnin , MJ Lowe (2005). Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biological Psychiatry 57, 10791088.

MT Banich (2009). Executive function: the search for an integrated account. Current Directions in Psychological Science 18, 8994.

AT Beck , CH Ward , M Mendelson , J Mock , J Erbaugh (1961). An inventory for measuring depression. Archives of General Psychiatry 4, 561571.

B Birmaher , S Khetarpal , D Brent , M Cully , L Balach , J Kaufman , SM Neer (1997). The Screen for Child Anxiety Related Emotional Disorders (SCARED): scale construction and psychometric characteristics. Journal of the American Academy of Child and Adolescent Psychiatry 36, 545553.

DA Brent , M Baugher , J Bridge , T Chen , L Chiappetta (1999). Age- and sex-related risk factors for adolescent suicide. Journal of the American Academy of Child and Adolescent Psychiatry 38, 14971505.

AJ Calder , AW Young , D Rowland , DI Perrett (1997). Computer-enhanced emotion in facial expressions. Proceedings in Biological Science 264, 919925.

AD Craig (2011). Significance of the insula for the evolution of human awareness of feelings from the body. Annals of the New York Academy of Sciences 1225, 7282.

KR Cullen , DG Gee , B Klimes-Dougan , V Gabbay , L Hulvershorn , BA Mueller , J Camchong , CJ Bell , A Houri , S Kumra , KO Lim , FX Castellanos , MP Milham (2009). A preliminary study of functional connectivity in co-morbid adolescent depression. Neuroscience Letters 460, 227231.

DP Dickstein , EC Finger , M Skup , DS Pine , JR Blair , E Leibenluft (2010). Altered neural function in pediatric bipolar disorder during reversal learning. Bipolar Disorders 12, 707719.

A Etkin , T Egner , R Kalisch (2011). Emotional processing in anterior cingulate and medial prefrontal cortex. Trends in Cognitive Science 15, 8593.

KJ Friston , C Buechel , GR Fink , J Morris , E Rolls , RJ Dolan (1997). Psychophysiological and modulatory interactions in neuroimaging. NeuroImage 6, 218229.

T Giesecke , RH Gracely , DA Williams , ME Geisser , FW Petzke , DJ Clauw (2005). The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort. Arthritis and Rheumatism 52, 15771584.

AR Gilbert , D Akkal , JRC Almeida , D Mataix-Cols , C Kalas , B Devlin , B Birmaher , ML Phillips (2005). Neural correlates of symptom dimensions in pediatric obsessive-compulsive disorder: a functional magnetic resonance imaging study. Journal of the American Academy of Child and Adolescent Psychiatry 48, 936944.

F Grabenhorst , ET Rolls (2011). Value, pleasure and choice in the ventral prefrontal cortex. Trends in Cognitive Science 15, 5667.

S Hassel , JR Almeida , N Kerr , S Nau , CD Ladouceur , K Fissell , DJ Kupfer , ML Phillips (2008). Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load. Bipolar Disorders 10, 916927.

JV Haxby , EA Hoffman , MI Gobbini (2000). The distributed human neural system for face perception. Trends in Cognitive Science 4, 223233.

LA Hulvershorn , K Cullen , A Anand (2011). Toward dysfunctional connectivity: a review of neuroimaging findings in pediatric major depressive disorder. Brain Imaging and Behavior 5, 307328.

F Jollant , F Bellivier , M Leboyer , B Astruc , S Torres , R Verdier , D Castelnau , A Malafosse , P Courtet (2005). Impaired decision making in suicide attempters. American Journal of Psychiatry 162, 304310.

F Jollant , NS Lawrence , V Giampietro , MJ Brammer , MA Fullana , D Drapier , P Courtet , ML Phillips (2008). Orbitofrontal cortex response to angry faces in men with histories of suicide attempts. American Journal of Psychiatry 165, 740748.

J Kaufman , B Birmaher , D Brent , U Rao , C Flynn , P Moreci , D Williamson , N Ryan (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry 36, 980988.

JG Keilp , HA Sackeim , BS Brodsky , MA Oquendo , KM Malone , JJ Mann (2001). Neuropsychological dysfunction in depressed suicide attempters. American Journal of Psychiatry 158, 735741.

WD Killgore , DA Yurgelun-Todd (2006). Ventromedial prefrontal activity correlates with depressed mood in adolescent children. NeuroReport 17, 167171.

P Kim , LA Thomas , BH Rosen , AM Moscicki , MA Brotman , CA Zarate , RJ Blair , DS Pine , E Liebenluft (2012). Differing amygdale responses to facial expressions in children and adults with bipolar disorder. American Journal of Psychiatry 169, 642649.

CD Ladouceur , T Farchione , V Diwadkar , P Pruitt , J Radwan , DA Axelson , B Birmaher , ML Phillips (2011). Differential patterns of abnormal activity and connectivity in the amygdala-prefrontal circuitry in bipolar-I and bipolar-NOS youth. Journal of the American Academy of Child and Adolescent Psychiatry 50, 12751289.

JY Lau , D Goldman , B Buzas , C Hodgkinson , E Leibenluft , E Nelson , L Sankin , DS Pine , M Ernst (2010). BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. NeuroImage 53, 952961.

NS Lawrence , AM Williams , S Surguladze , V Giampietro , MJ Brammer , C Andrew , S Frangou , C Ecker , ML Phillips (2004). Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biological Psychiatry 55, 578587.

JJ Mann , YY Huang , MD Underwood , SA Kassir , S Oppenheim , TM Kelly , AJ Dwork , V Arango (2000). A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Archives of General Psychiatry 57, 729738.

CS Monk , EB McClure , EE Nelson , E Zarahn , RM Bilder , E Leibenluft , DS Charney , M Ernst , DS Pine (2003). Adolescent immaturity in attention-related brain engagement to emotional facial expressions. NeuroImage 20, 420428.

CS Monk , EH Telzer , K Mogg , BP Bradley , X Mai , HM Louro , G Chen , EB McClure-Tone , M Ernst , DS Pine (2008). Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Archives of General Psychiatry 65, 568576.

L Nummenmaa , J Hirvonen , R Parkkola , JK Hietanen (2008). Is emotional contagion special? An fMRI study on neural systems for affective and cognitive empathy. NeuroImage 43, 571580.

MA Oquendo , GP Placidi , KM Malone , C Campbell , J Keilp , B Brodsky , LS Kegeles , TB Cooper , RV Parsey , RL van Heertum , JJ Mann (2003 b). Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Archives of General Psychiatry 60, 1422.

LA Pan , SC Batezati-Alves , JR Almeida , A Segreti , D Akkal , S Hassel , S Lakdawala , DA Brent , ML Phillips (2011). Dissociable patterns of neural activity during response inhibition in depressed adolescents with and without suicidal behavior. Journal of the American Academy of Child and Adolescent Psychiatry 50, 602611.

AC Petersen , L Crockett , M Richards , A Boxer (1988). A self-report measure of pubertal status: reliability, validity, and initial norms. Journal of Youth and Adolescence 17, 117133.

K Posner , MA Oquendo , M Gould , B Stanley , M Davies (2007). Columbia Classification Algorithm of Suicide Assessment (C-CASA): classification of suicidal events in the FDA's pediatric suicidal risk analysis of antidepressants. American Journal of Psychiatry 164, 10351043.

M Sugiura , R Kawashima , M Nakagawa , K Okada , T Sato , R Goto , K Sato , S Ono , T Schormann , K Zilles , H Fukuda (2000). Correlation between human personality and neural activity in cerebral cortex. NeuroImage 11, 541546.

S Surguladze , MJ Brammer , P Keedwell , V Giampietro , AW Young , MJ Travis , SC Williams , ML Phillips (2005). A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biological Psychiatry 57, 201209.

KS Taylor , DA Seminowicz , KD Davis (2009). Two systems of resting state connectivity between the insula and cingulate cortex. Human Brain Mapping 30, 27312745.

A Versace , WK Thompson , D Zhou , JR Almeida , S Hassel , CR Klein , DJ Kupfer , ML Phillips (2010). Abnormal left and right amygdala–orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder. Biological Psychiatry 67, 422431.

DA Yurgelun-Todd , WD Killgore (2006). Fear-related activity in the prefrontal cortex increases with age during adolescence: a preliminary fMRI study. Neuroscience Letters 406, 194199.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: