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Changes in genetic risk for emotional eating across the menstrual cycle: a longitudinal study

  • K. L. Klump (a1), B. A. Hildebrandt (a1), S. M. O'Connor (a1), P. K. Keel (a2), M. Neale (a3), C. L. Sisk (a1) (a4), S. Boker (a5) and S. A. Burt (a1)...
Abstract
Background

Previous studies have shown significant within-person changes in binge eating and emotional eating across the menstrual cycle, with substantial increases in both phenotypes during post-ovulation. Increases in both estradiol and progesterone levels appear to account for these changes in phenotypic risk, possibly via increases in genetic effects. However, to date, no study has examined changes in genetic risk for binge phenotypes (or any other phenotype) across the menstrual cycle. The goal of the present study was to examine within-person changes in genetic risk for emotional eating scores across the menstrual cycle.

Method

Participants were 230 female twin pairs (460 twins) from the Michigan State University Twin Registry who completed daily measures of emotional eating for 45 consecutive days. Menstrual cycle phase was coded based on dates of menstrual bleeding and daily ovarian hormone levels.

Results

Findings revealed important shifts in genetic and environmental influences, where estimates of genetic influences were two times higher in post- as compared with pre-ovulation. Surprisingly, pre-ovulation was marked by a predominance of environmental influences, including shared environmental effects which have not been previously detected for binge eating phenotypes in adulthood.

Conclusions

Our study was the first to examine within-person shifts in genetic and environmental influences on a behavioral phenotype across the menstrual cycle. Results highlight a potentially critical role for these shifts in risk for emotional eating across the menstrual cycle and underscore the need for additional, large-scale studies to identify the genetic and environmental factors contributing to menstrual cycle effects.

Copyright
Corresponding author
* Address for correspondence: K. L. Klump, Ph.D., Department of Psychology, Michigan State University, 316 Physics Road – Room 107B Psychology, East Lansing, MI 48824-1116, USA. (Email: klump@msu.edu)
References
Hide All
Akaike H (1987). Factor analysis and AIC. Psychometrika 52, 317332.
Asarian L, Geary N (2006). Modulation of appetite by gonadal steroid hormones. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 361, 12511263.
Asarian L, Geary N (2013). Sex differences in the physiology of eating. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 305, R1215R1267.
Becker JB (1999). Gender differences in dopaminergic function in striatum and nucleus accumbens. Pharmacology, Biochemistry and Behavior 64, 803812.
Boker SM, Neale MC, Klump KL (2014). A differential equations model for the ovarian hormone cycle. In Handbook of Relational Developmental Systems: Emerging Methods and Concepts (ed. Molenaar P.C., Lerner R. and Newell K.). John Wiley & Sons: New York.
Bulik CM, Sullivan PF, Kendler KS (1998). Heritability of binge-eating and broadly defined bulimia nervosa. Biological Psychiatry 44, 12101218.
Bulik CM, Sullivan PF, Wade TD, Kendler KS (2000). Twin studies of eating disorders: a review. International Journal of Eating Disorders 17, 251261.
Burt SA, Klump KL (2013). The Michigan State University Twin Registry (MSUTR): an update. Twin Research and Human Genetics 16, 344350.
Deaver CM, Miltenberger RG, Symth J, Meidinger A, Crosby R (2003). An evaluation of affect and binge eating. Behavior Modification 27, 578599.
Edler C, Lipson SF, Keel PK (2007). Ovarian hormones and binge eating in bulimia nervosa. Psychological Medicine 37, 131141.
Fairburn CG (2008). Cognitive Behavior Therapy and Eating Disorders. Guilford Press: New York.
Graves NS, Hayes H, Fan L, Curtis KS (2011). Time course of behavioral, physiological, and morphological changes after estradiol treatment of ovariectomized rats. Physiology and Behavior 103, 261267.
Hildebrandt BA, Racine SE, Keel PK, Burt SA, Neale M, Boker S, Sisk CL, Klump KL (2014). The effects of ovarian hormones and emotional eating on changes in weight preoccupation across the menstrual cycle. International Journal of Eating Disorders 48, 477486.
Hildebrandt T, Alfano L, Tricamo M, Pfaff DW (2010). Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa. Clinical Psychology Review 30, 655668.
Klump KL (2013). Puberty as a critical risk period for eating disorders: a review of human and animal studies. Hormones and Behavior 64, 399410.
Klump KL, Burt SA (2006). The Michigan State University Twin Registry (MSUTR): genetic, environmental and neurobiological influences on behavior across development. Twin Research and Human Genetics 9, 971977.
Klump KL, Burt SA, McGue M, Iacono WG (2007). Changes in genetic and environmental influences on disordered eating across adolescence: a longitudinal twin study. Archives of General Psychiatry 64, 14091415.
Klump KL, Burt SA, McGue M, Iacono WG, Wade TM (2010 a). Age differences in genetic and environmental influences on weight and shape concerns. International Journal of Eating Disorders 43, 679688.
Klump KL, Keel PK, Burt SA, Racine SE, Neale MC, Sisk CL, Boker S (2013 a). Ovarian hormones and emotional eating across the menstrual cycle: an examination of the potential moderating effects of body mass index and dietary restraint. International Journal of Eating Disorders 46, 256263.
Klump KL, Keel PK, Culbert KM, Edler C (2008). Ovarian hormones and binge eating: exploring associations in community samples. Psychological Medicine 38, 17491757.
Klump KL, Keel PK, Racine SE, Burt SA, Neale M, Sisk CL, Boker S, Hu JY (2013 b). The interactive effects of estrogen and progesterone on changes in emotional eating across the menstrual cycle. Journal of Abnormal Psychology 122, 131137.
Klump KL, Keel PK, Sisk CL, Burt SA (2010 b). Preliminary evidence that estradiol moderates genetic influences on disordered eating attitudes and behaviors during puberty. Psychological Medicine 40, 17451753.
Klump KL, McGue M, Iacono WG (2000). Age differences in genetic and environmental influences on eating attitudes and behaviors in female adolescent twins. Journal of Abnormal Psychology 109, 239251.
Klump KL, McGue M, Iacono WG (2003). Differential heritability of eating attitudes and behaviors in prepubertal versus pubertal twins. International Journal of Eating Disorders 33, 287292.
Klump KL, Racine SE, Hildebrandt B, Burt SA, Neale M, Sisk CL, Boker S, Keel PK (2014). Ovarian hormone influences on dysregulated eating: a comparison of associations in women with versus without binge episodes. Clinical Psychological Science 2, 545559.
Laghi F, Pompili S, Baumgartner E, Baiocco R (2015). The role of sensation seeking and motivations for eating in female and male adolescents who binge eat. Eating Behaviors 17, 119124.
Lester NA, Keel PK, Lipson SF (2003). Symptom fluctuation in bulimia nervosa: relation to menstrual-cycle phase and cortisol levels. Psychological Medicine 33, 5160.
Lluch A, Herbert B, Mejean L, Siest G (2000). Dietary intakes, eating style and overweight in Stanilas Family Study. International Journal of Obesity 24, 14931499.
Logan PC, Ponnampalam AP, Steiner M, Mitchell MD (2012). Effect of cyclic AMP and estrogen/progesterone on the transcription of DNA methyltransferases during the decidualization of human endometrial stromal cells. Molecular Human Reproduction 19, 302312.
Martin MG, Eaves LJ, Kearsey MJ, Davies P (1978). The power of the classical twin study. Heredity 40, 97116.
McManus F, Waller GI (1995). A functional analysis of binge-eating. Clinical Psychology Review 15, 845863.
Neale MC, Boker SM, Xie G, Maes HH (2003). Mx: Statistical Modeling. Department of Psychiatry: Richmond, VA.
Nguyen-Michel ST, Unger JB, Spruijt-Metz D (2007). Dietary correlates of emotional eating in adolescence. Appetite 49, 494499.
Ostlund H, Keller E, Hurd YL (2003). Estrogen receptor gene expression in relation to neuropsychiatric disorders. Annals of the New York Academy of Sciences 1007, 5463.
Purcell S (2002). Variance components models for gene–environment interaction in twin analysis. Twin Research 5, 554571.
Racine SE, Culbert KM, Larson CL, Klump KL (2009). The possible influences of impulsivity and dietary restraint on associations between serotonin genes and binge eating. Journal of Psychiatric Research 43, 12781286.
Racine SE, Keel PK, Burt SA, Sisk CL, Neale M, Boker S, Klump KL (2013). Exploring the relationship between negative urgency and dysregulated eating: etiologic associations and the role of negative affect. Journal of Abnormal Psychology 122, 433444.
Roepke TA (2009). Oestrogen modulates hypothalamic control of energy homeostasis through multiple mechanisms. Journal of Neuroendocrinology 21, 141150.
Roepke TA, Qiu J, Bosch MA, Ronnekleiv OK, Kelly MJ (2009). Cross-talk between membrane-initiated and nuclear-initiated oestrogen signalling in the hypothalamus. Journal of Neuroendocrinology 21, 263270.
Romeo RD (2003). Puberty: a period of both organizational and activational effects of steroid hormones on neurobehavioural development. Journal of Neuroendocrinology 15, 11851192.
Santollo J, Marshall A, Daniels D (2012). Activation of membrane associated estrogen receptors decreases food and water intake in ovariectomized rats. Endocrinology 154, 320329.
Scherag S, Hebebrand J, Hinney A (2010). Eating disorders: the current status of molecular genetic research. European Child and Adolescent Psychiatry 19, 211226.
Schwarz GE (1978). Estimating the dimension of a model. Annals of Statistics 6, 461464.
Schwarz JM, Nugent BM, McCarthy MM (2010). Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life span. Endocrinology 151, 48714881.
Sisk CL, Zehr JL (2005). Puberty hormones organize the adolescent brain and behavior. Frontiers in Neuroendocrinology 26, 163174.
Snoek HM, van Strien T, Janssens JM, Engels RC (2007). Emotional, external, restrained eating and overweight in Dutch adolescents. Scandinavian Journal of Psychology 48, 2332.
Sullivan PF, Bulik CR, Kendler K (1998). Genetic epidemiology of binging and vomiting. British Journal of Psychiatry 173, 7579.
Van Strien T (2000). Ice-cream consumption, tendency toward overeating, and personality. Appetite 52, 380387.
Van Strien T, Frijters JE, Bergers GP, Defares PB (1986). The Dutch Eating Behavior Questionnaire (DEBQ) for assessment of restrained, emotional, and external eating behavior. International Journal of Eating Disorders 5, 295315.
Van Strien T, Snoek HM, van der Zwaluw CS, Engles RCME (2010). Parental control and the dopamine D2 receptor gene (DRD2) interaction on emotional eating in adolescence. Appetite 54, 255261.
Wade TD, Gordon S, Medland S, Bulik CM, Heath AC, Montgomery GW, Martin NG (2013). Genetic variants associated with disordered eating. International Journal of Eating Disorders 46, 594608.
Wardle J (1987). Eating style: a validation study of the Dutch Eating Behaviour Questionnaire in normal subjects and women with eating disorders. Journal of Psychosomatic Research 31, 161169.
Wilson JD, Foster DW, Kronenberg HM, Larsen PR (1998). Williams Textbook of Endocrinology, 9th edn. W.B. Saunders Company: Philadelphia, PA.
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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
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