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Changes in genetic risk for emotional eating across the menstrual cycle: a longitudinal study

  • K. L. Klump (a1), B. A. Hildebrandt (a1), S. M. O'Connor (a1), P. K. Keel (a2), M. Neale (a3), C. L. Sisk (a1) (a4), S. Boker (a5) and S. A. Burt (a1)...
Abstract
Background

Previous studies have shown significant within-person changes in binge eating and emotional eating across the menstrual cycle, with substantial increases in both phenotypes during post-ovulation. Increases in both estradiol and progesterone levels appear to account for these changes in phenotypic risk, possibly via increases in genetic effects. However, to date, no study has examined changes in genetic risk for binge phenotypes (or any other phenotype) across the menstrual cycle. The goal of the present study was to examine within-person changes in genetic risk for emotional eating scores across the menstrual cycle.

Method

Participants were 230 female twin pairs (460 twins) from the Michigan State University Twin Registry who completed daily measures of emotional eating for 45 consecutive days. Menstrual cycle phase was coded based on dates of menstrual bleeding and daily ovarian hormone levels.

Results

Findings revealed important shifts in genetic and environmental influences, where estimates of genetic influences were two times higher in post- as compared with pre-ovulation. Surprisingly, pre-ovulation was marked by a predominance of environmental influences, including shared environmental effects which have not been previously detected for binge eating phenotypes in adulthood.

Conclusions

Our study was the first to examine within-person shifts in genetic and environmental influences on a behavioral phenotype across the menstrual cycle. Results highlight a potentially critical role for these shifts in risk for emotional eating across the menstrual cycle and underscore the need for additional, large-scale studies to identify the genetic and environmental factors contributing to menstrual cycle effects.

Copyright
Corresponding author
* Address for correspondence: K. L. Klump, Ph.D., Department of Psychology, Michigan State University, 316 Physics Road – Room 107B Psychology, East Lansing, MI 48824-1116, USA. (Email: klump@msu.edu)
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H Akaike (1987). Factor analysis and AIC. Psychometrika 52, 317332.

L Asarian , N Geary (2006). Modulation of appetite by gonadal steroid hormones. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 361, 12511263.

JB Becker (1999). Gender differences in dopaminergic function in striatum and nucleus accumbens. Pharmacology, Biochemistry and Behavior 64, 803812.

CM Bulik , PF Sullivan , KS Kendler (1998). Heritability of binge-eating and broadly defined bulimia nervosa. Biological Psychiatry 44, 12101218.

CM Bulik , PF Sullivan , TD Wade , KS Kendler (2000). Twin studies of eating disorders: a review. International Journal of Eating Disorders 17, 251261.

CM Deaver , RG Miltenberger , J Symth , A Meidinger , R Crosby (2003). An evaluation of affect and binge eating. Behavior Modification 27, 578599.

NS Graves , H Hayes , L Fan , KS Curtis (2011). Time course of behavioral, physiological, and morphological changes after estradiol treatment of ovariectomized rats. Physiology and Behavior 103, 261267.

BA Hildebrandt , SE Racine , PK Keel , SA Burt , M Neale , S Boker , CL Sisk , KL Klump (2014). The effects of ovarian hormones and emotional eating on changes in weight preoccupation across the menstrual cycle. International Journal of Eating Disorders 48, 477486.

T Hildebrandt , L Alfano , M Tricamo , DW Pfaff (2010). Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa. Clinical Psychology Review 30, 655668.

KL Klump (2013). Puberty as a critical risk period for eating disorders: a review of human and animal studies. Hormones and Behavior 64, 399410.

KL Klump , SA Burt , M McGue , WG Iacono (2007). Changes in genetic and environmental influences on disordered eating across adolescence: a longitudinal twin study. Archives of General Psychiatry 64, 14091415.

KL Klump , SA Burt , M McGue , WG Iacono , TM Wade (2010 a). Age differences in genetic and environmental influences on weight and shape concerns. International Journal of Eating Disorders 43, 679688.

KL Klump , PK Keel , SA Burt , SE Racine , MC Neale , CL Sisk , S Boker (2013 a). Ovarian hormones and emotional eating across the menstrual cycle: an examination of the potential moderating effects of body mass index and dietary restraint. International Journal of Eating Disorders 46, 256263.

KL Klump , PK Keel , SE Racine , SA Burt , M Neale , CL Sisk , S Boker , JY Hu (2013 b). The interactive effects of estrogen and progesterone on changes in emotional eating across the menstrual cycle. Journal of Abnormal Psychology 122, 131137.

KL Klump , M McGue , WG Iacono (2000). Age differences in genetic and environmental influences on eating attitudes and behaviors in female adolescent twins. Journal of Abnormal Psychology 109, 239251.

KL Klump , M McGue , WG Iacono (2003). Differential heritability of eating attitudes and behaviors in prepubertal versus pubertal twins. International Journal of Eating Disorders 33, 287292.

KL Klump , SE Racine , B Hildebrandt , SA Burt , M Neale , CL Sisk , S Boker , PK Keel (2014). Ovarian hormone influences on dysregulated eating: a comparison of associations in women with versus without binge episodes. Clinical Psychological Science 2, 545559.

F Laghi , S Pompili , E Baumgartner , R Baiocco (2015). The role of sensation seeking and motivations for eating in female and male adolescents who binge eat. Eating Behaviors 17, 119124.

NA Lester , PK Keel , SF Lipson (2003). Symptom fluctuation in bulimia nervosa: relation to menstrual-cycle phase and cortisol levels. Psychological Medicine 33, 5160.

A Lluch , B Herbert , L Mejean , G Siest (2000). Dietary intakes, eating style and overweight in Stanilas Family Study. International Journal of Obesity 24, 14931499.

PC Logan , AP Ponnampalam , M Steiner , MD Mitchell (2012). Effect of cyclic AMP and estrogen/progesterone on the transcription of DNA methyltransferases during the decidualization of human endometrial stromal cells. Molecular Human Reproduction 19, 302312.

MG Martin , LJ Eaves , MJ Kearsey , P Davies (1978). The power of the classical twin study. Heredity 40, 97116.

F McManus , GI Waller (1995). A functional analysis of binge-eating. Clinical Psychology Review 15, 845863.

ST Nguyen-Michel , JB Unger , D Spruijt-Metz (2007). Dietary correlates of emotional eating in adolescence. Appetite 49, 494499.

H Ostlund , E Keller , YL Hurd (2003). Estrogen receptor gene expression in relation to neuropsychiatric disorders. Annals of the New York Academy of Sciences 1007, 5463.

S Purcell (2002). Variance components models for gene–environment interaction in twin analysis. Twin Research 5, 554571.

SE Racine , KM Culbert , CL Larson , KL Klump (2009). The possible influences of impulsivity and dietary restraint on associations between serotonin genes and binge eating. Journal of Psychiatric Research 43, 12781286.

SE Racine , PK Keel , SA Burt , CL Sisk , M Neale , S Boker , KL Klump (2013). Exploring the relationship between negative urgency and dysregulated eating: etiologic associations and the role of negative affect. Journal of Abnormal Psychology 122, 433444.

TA Roepke (2009). Oestrogen modulates hypothalamic control of energy homeostasis through multiple mechanisms. Journal of Neuroendocrinology 21, 141150.

TA Roepke , J Qiu , MA Bosch , OK Ronnekleiv , MJ Kelly (2009). Cross-talk between membrane-initiated and nuclear-initiated oestrogen signalling in the hypothalamus. Journal of Neuroendocrinology 21, 263270.

RD Romeo (2003). Puberty: a period of both organizational and activational effects of steroid hormones on neurobehavioural development. Journal of Neuroendocrinology 15, 11851192.

J Santollo , A Marshall , D Daniels (2012). Activation of membrane associated estrogen receptors decreases food and water intake in ovariectomized rats. Endocrinology 154, 320329.

S Scherag , J Hebebrand , A Hinney (2010). Eating disorders: the current status of molecular genetic research. European Child and Adolescent Psychiatry 19, 211226.

GE Schwarz (1978). Estimating the dimension of a model. Annals of Statistics 6, 461464.

JM Schwarz , BM Nugent , MM McCarthy (2010). Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life span. Endocrinology 151, 48714881.

CL Sisk , JL Zehr (2005). Puberty hormones organize the adolescent brain and behavior. Frontiers in Neuroendocrinology 26, 163174.

HM Snoek , T van Strien , JM Janssens , RC Engels (2007). Emotional, external, restrained eating and overweight in Dutch adolescents. Scandinavian Journal of Psychology 48, 2332.

PF Sullivan , CR Bulik , K Kendler (1998). Genetic epidemiology of binging and vomiting. British Journal of Psychiatry 173, 7579.

T Van Strien (2000). Ice-cream consumption, tendency toward overeating, and personality. Appetite 52, 380387.

T Van Strien , JE Frijters , GP Bergers , PB Defares (1986). The Dutch Eating Behavior Questionnaire (DEBQ) for assessment of restrained, emotional, and external eating behavior. International Journal of Eating Disorders 5, 295315.

T Van Strien , HM Snoek , CS van der Zwaluw , RCME Engles (2010). Parental control and the dopamine D2 receptor gene (DRD2) interaction on emotional eating in adolescence. Appetite 54, 255261.

TD Wade , S Gordon , S Medland , CM Bulik , AC Heath , GW Montgomery , NG Martin (2013). Genetic variants associated with disordered eating. International Journal of Eating Disorders 46, 594608.

J Wardle (1987). Eating style: a validation study of the Dutch Eating Behaviour Questionnaire in normal subjects and women with eating disorders. Journal of Psychosomatic Research 31, 161169.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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