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Curiosity killed the cat: no evidence of an association between cat ownership and psychotic symptoms at ages 13 and 18 years in a UK general population cohort

  • F. Solmi (a1), J. F. Hayes (a1), G. Lewis (a1) and J. B. Kirkbride (a1)
Abstract
Background

Congenital or early life infection with Toxoplasma gondii has been implicated in schizophrenia aetiology. Childhood cat ownership has been hypothesized as an intermediary marker of T. gondii infection and, by proxy, as a risk factor for later psychosis. Evidence supporting this hypothesis is, however, limited.

Method

We used birth cohort data from the Avon Longitudinal Study of Parents and Children (ALSPAC) to investigate whether cat ownership in pregnancy and childhood (ages 4 and 10 years) was associated with psychotic experiences (PEs) in early (age 13, N = 6705) and late (age 18, N = 4676) adolescence, rated from semi-structured interviews. We used logistic regression to examine associations between cat ownership and PEs, adjusting for several sociodemographic and socioeconomic factors, household characteristics and dog ownership. Missing data were handled via multiple imputation.

Results

Cat ownership during pregnancy was not associated with PEs at age 13 years [adjusted odds ratio (OR) 1.15, 95% confidence interval (CI) 0.97–1.35] or 18 years (OR 1.08, 95% CI 0.86–1.35). Initial univariable evidence that cat ownership at ages 4 and 10 years was associated with PEs at age 13 years did not persist after multivariable adjustment (4 years: OR 1.18, 95% CI 0.94–1.48; 10 years: OR 1.12, 95% CI 0.92–1.36). There was no evidence that childhood cat ownership was associated with PEs at age 18 years.

Conclusions

While pregnant women should continue to avoid handling soiled cat litter, given possible T. gondii exposure, our study strongly indicates that cat ownership in pregnancy or early childhood does not confer an increased risk of later adolescent PEs.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
*Address for correspondence: F. Solmi, Ph.D., UCL Division of Psychiatry, 6th Floor, Wing B, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK. (Email: francesca.solmi@ucl.ac.uk)
References
Hide All
AngoldA, CostelloEJ, MesserSC, PicklesA, WinderF, SilverD (1995). Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents. International Journal of Methods in Psychiatric Research 5, 237249.
BoydA, GoldingJ, MacleodJ, LawlorD, FraserA, HendersonJ, MolloyL, NessA, RingS, Davey SmithG (2012). Cohort Profile: The ‘Children of the 90s’ – the index offspring of the Avon Longitudinal Study of Parents and Children. International Journal of Epidemiology 42, 111127.
BrownAS, SchaeferCA, QuesenberryCP, LiuL, BabulasVP, SusserES (2005). Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. American Journal of Psychiatry 162, 767773.
CarruthersVB, SuzukiY (2007). Effects of Toxoplasma gondii infection on the brain. Schizophrenia Bulletin 33, 745751.
CetinkayaZ, YazarS, GeciciO, NamliMN (2007). Anti-Toxoplasma gondii antibodies in patients with schizophrenia – preliminary findings in a Turkish sample. Schizophrenia Bulletin 33, 789791.
CookAJ, GilbertRE, BuffolanoW, ZuffereyJ, PetersenE, JenumPA, FoulonW, SempriniAE, DunnDT (2000). Sources of toxoplasma infection in pregnant women: European multicentre case-control study. European Research Network on Congenital Toxoplasmosis. British Medical Journal (Clinical Research Edition) 321, 142147.
DorringtonS, ZammitS, AsherL, EvansJ, HeronJ, LewisG (2014). Perinatal maternal life events and psychotic experiences in children at twelve years in a birth cohort study. Schizophrenia Research 152, 158163.
FisherHL, CaspiA, PoultonR, MeierMH, HoutsR, HarringtonH, ArseneaultL, MoffittTE (2013). Specificity of childhood psychotic symptoms for predicting schizophrenia by 38 years of age: a birth cohort study. Psychological Medicine 43, 20772086.
GaskellEA, SmithJE, PinneyJW, WestheadDR, McConkeyGA (2009). A unique dual activity amino acid hydroxylase in Toxoplasma gondii . PLoS ONE 4, e4801.
HorwoodJ, SalviG, ThomasK, DuffyL, GunnellD, HollisC, LewisG, MenezesP, ThompsonA, WolkeD, ZammitS, HarrisonG (2008). IQ and non-clinical psychotic symptoms in 12-year-olds: results from the ALSPAC birth cohort. British Journal of Psychiatry 193, 185191.
KannanG, PletnikovMV (2012). Toxoplasma gondii and cognitive deficits in schizophrenia: an animal model perspective. Schizophrenia Bulletin 38, 11551161.
KapperudG, JenumPA, Stray-PedersenB, MelbyKK, EskildA, EngJ (1996). Risk factors for Toxoplasma gondii infection in pregnancy: results of a prospective case-control study in Norway. American Journal of Epidemiology 144, 405412.
KelleherI, KeeleyH, CorcoranP, LynchF, FitzpatrickC, DevlinN, MolloyC, RoddyS, ClarkeMC, HarleyM, ArseneaultL, WassermanC, CarliV, SarchiaponeM, HovenC, WassermanD, CannonM (2012). Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies. British Journal of Psychiatry 201, 2632.
KirkbrideJB, ErrazurizA, CroudaceTJ, MorganC, JacksonD, BoydellJ, MurrayRM, JonesPB (2012). Incidence of schizophrenia and other psychoses in England, 1950–2009: a systematic review and meta-analyses. PLoS ONE 7, e31660.
KleinhausK, HarlapS, PerrinMC, ManorO, Calderon-MargalitR, FriedlanderY, MalaspinaD (2008). Twin pregnancy and the risk of schizophrenia. Schizophrenia Research 105, 197200.
LaurensKR, HodginsS, MaughanB, MurrayRM, RutterML, TaylorEA (2007). Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9–12 years. Schizophrenia Research 90, 130146.
LichtensteinP, YipBH, BjörkC, PawitanY, CannonTD, SullivanPF, HultmanCM (2009). Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 373, 234239.
Lopez-CastromanJ, GómezDD, BellosoJJC, Fernandez-NavarroP, Perez-RodriguezMM, VillamorIB, NavarreteFF, GinestarCM, CurrierD, TorresMR, Navio-AcostaM, Saiz-RuizJ, Jimenez-ArrieroMA, Baca-GarciaE (2010). Differences in maternal and paternal age between schizophrenia and other psychiatric disorders. Schizophrenia Research 116, 184–90.
McConkeyGA, MartinHL, BristowGC, WebsterJP (2013). Toxoplasma gondii infection and behaviour - location, location, location? Journal of Experimental Biology 216, 113119.
MortensenPB, Nørgaard-PedersenB, WaltoftBL, SørensenTL, HougaardD, TorreyEF, YolkenRH (2007a). Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth. Biological Psychiatry 61, 688693.
MortensenPB, Nørgaard-PedersenB, WaltoftBL, SørensenTL, HougaardD, YolkenRH (2007b). Early infections of Toxoplasma gondii and the later development of schizophrenia. Schizophrenia Bulletin 33, 741744.
MulvanyF, O'CallaghanE, TakeiN, ByrneM, FearonP, LarkinC, WiersmaD, GielR, De JongA, SlooffC, ArgyleM, JonesP, BebbingtonP, FoersterA, LewisS, MurrayR, RussellA, AroS, AroH, KeskimäkiI, WarnerR, de GirolamoG, CroudaceT, KayneR, JonesP, HarrisonG, GeddesJ, LawrieS, HultmanC, SparénP, TakeiN, MurrayR, CnattingiusS, GeddesJ, ShamP, O'CallaghanE, TakeiN, SusserE, LinS, WynnS, WynnA, DoyleW, SaxenaS, MajeedA, JonesM, TurnerR, WagenfeldM, HareE, PriceJ, SlaterE, LoebelA, LiebermanJ, AlvirJ, MayerhoffD, GeislerS, SzymanskiS, CarboneS, HarriganS, McGorryP, BirtchnellJ, SchwartzJ, FennigS, Tanenberg-KarantM, CarlsonG, CraigT, GalambosN, MäkikyröT, IsohanniM, MoringJ, DohrenwendB, LevavI, ShroutP, SchwartzS, NavehG, LinkB, CooperB, RobertsK, BosmaH, SchrijversC, MackenbachJ, ClarkeM, BrownS, McTigueO, GervinM, MurphyP, WaddingtonJ (2001). Effect of social class at birth on risk and presentation of schizophrenia: case-control study. British Medical Journal (Clinical Research Edition) 323, 13981401.
OnstadS, SkreI, TorgersenS, KringlenE (1992). Birthweight and obstetric complications in schizophrenic twins. Blackwell Publishing Ltd Acta Psychiatrica Scandinavica 85, 7073.
PetersenL, MortensenPB, PedersenCB (2011). Paternal age at birth of first child and risk of schizophrenia. American Psychiatric Publishing Arlington, VA American Journal of Psychiatry 168, 8288.
PoultonR, CaspiA, MoffittTE, CannonM, MurrayR, HarringtonH (2000). Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Archives of General Psychiatry 57, 10531058.
PrandovszkyE, GaskellE, MartinH, DubeyJP, WebsterJP, McConkeyGA (2011). The neurotropic parasite Toxoplasma gondii increases dopamine metabolism. Public Library of Science PLoS ONE 6, e23866.
RoystonP, WhiteIR (2011). Multiple Imputation by Chained Equations (MICE): implementation in Stata. Journal of Statistical Software 45, 120.
ShafferD, FisherP, LucasCP, DulcanMK, Schwab-StoneME (2000). NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. Journal of the American Academy of Child and Adolescent Psychiatry 39, 2838.
SinghSP, WinsperC, WolkeD, et al. (2014). School mobility and prospective pathways to psychotic-like symptoms in early adolescence: a prospective birth cohort study. Journal of the American Academy of Child and Adolescent Psychiatry 53, 518–27.
SiposA, RasmussenF, HarrisonG, TyneliusP, LewisG, LeonDA, GunnellD (2004). Paternal age and schizophrenia: a population based cohort study. British Medical Journal (Clinical Research Edition) 329, 1070.
StataCorp (2013). Stata Statistical Software: Release 13. StataCorp LP: College Station, TX 13.
SterneJAC, WhiteIR, CarlinJB, SprattM, RoystonP, KenwardMG, WoodAM, CarpenterJR (2009). Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. British Medical Journal (Clinical Research Edition) 338, b2393.
SugdenK, MoffittTE, PintoL, PoultonR, WilliamsBS, CaspiA (2016). Is Toxoplasma gondii infection related to brain and behavior impairments in humans? Evidence from a population-representative birth cohort. Public Library of Science PLoS ONE 11, e0148435.
TaylorMR, LennonB, HollandCV, CafferkeyM (1997). Community study of toxoplasma antibodies in urban and rural schoolchildren aged 4 to 18 years. Archives of Disease in Childhood 77, 406409.
TenterAM, HeckerothAR, WeissLM (2000). Toxoplasma gondii: from animals to humans. International Journal for Parasitology 30, 12171258.
TextorJ, HardtJ, KnüppelS (2011). DAGitty. Epidemiology 22, 745.
TextorJ, LiśkiewiczM (2011). Adjustment criteria in causal diagrams: an algorithmic perspective. In Proceedings of the 27th Conference on Uncertainty in Artificial Intelligence, pp. 681688.
TorreyEF, BartkoJJ, YolkenRH (2012). Toxoplasma gondii and other risk factors for schizophrenia: an update. Schizophrenia Bulletin 38, 642647.
TorreyEF, RawlingsR, YolkenRH (2000). The antecedents of psychoses: a case-control study of selected risk factors. Schizophrenia Research 46, 1723.
TorreyEF, SimmonsW, YolkenRH (2015). Is childhood cat ownership a risk factor for schizophrenia later in life? Schizophrenia Research 165, 12.
TorreyEF, YolkenRH (1995). Could schizophrenia be a viral zoonosis transmitted from house cats? Schizophrenia Bulletin 21, 167171.
WebsterJP, KaushikM, BristowGC, McConkeyGA (2013). Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour? Journal of Experimental Biology 216, 99112.
WernerS, MalaspinaD, RabinowitzJ (2007). Socioeconomic status at birth is associated with risk of Schizophrenia: population-based multilevel study. Schizophrenia Bulletin 33, 13731378.
WestgarthC, HeronJ, NessAR, BundredP, GaskellRM, CoyneKP, GermanAJ, McCuneS, DawsonS (2010). Family pet ownership during childhood: findings from a UK birth cohort and implications for public health research. International Journal of Environmental Research and Public Health 7, 37043729.
WHO (1994). SCAN: Schedules for Clinical Assessment in Neuropsychiatry, Version 2.0. Geneva.
WolfPJ, HamiltonFE (2015). Flawed analyses undermine proposed relationship between childhood cat ownership and schizophrenia. Schizophrenia Research 168, 596.
YukselP, AlpayN, BaburC, BayarR, SaribasS, KarakoseAR, AksoyC, AsianM, MehmetaliS, KilicS, BalciogluI, HamancaO, DiricanA, KucukbasmaciO, OnerA, TorunMM, KocazeybekB (2010). The role of latent toxoplasmosis in the aetiopathogenesis of schizophrenia – the risk factor or an indication of a contact with cat? Folia Parasitologica 57, 121128.
ZammitS, HorwoodJ, ThompsonA, ThomasK, MenezesP, GunnellD, HollisC, WolkeD, LewisG, HarrisonG (2008). Investigating if psychosis-like symptoms (PLIKS) are associated with family history of schizophrenia or paternal age in the ALSPAC birth cohort. Schizophrenia Research 104, 279286.
ZammitS, ThomasK, ThompsonA, HorwoodJ, MenezesP, GunnellD, HollisC, WolkeD, LewisG, HarrisonG (2009). Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring. British Journal of Psychiatry 195, 294300.
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