Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Open access
  • Cited by 4
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Murray, Robin M. Quigley, Harriet Quattrone, Diego Englund, Amir and Di Forti, Marta 2016. Traditional marijuana, high-potency cannabis and synthetic cannabinoids: increasing risk for psychosis. World Psychiatry, Vol. 15, Issue. 3, p. 195.


    Zorlu, Nabi Angelique Di Biase, Maria Kalaycı, Çiğdem Çolak Zalesky, Andrew Bağcı, Başak Oğuz, Nihan Gelal, Fazıl Beşiroğlu, Lütfullah Gülseren, Şeref Sarıçiçek, Aybala Bora, Emre and Pantelis, Christos 2016. Abnormal white matter integrity in synthetic cannabinoid users. European Neuropsychopharmacology,


    Rigucci, Silvia Santi, Giulia Corigliano, Valentina Imola, Annamaria Rossi-Espagnet, Camilla Mancinelli, Iginia De Pisa, Eleonora Manfredi, Giovanni Bozzao, Alessandro Carducci, Filippo Girardi, Paolo and Comparelli, Anna 2016. White matter microstructure in ultra-high risk and first episode schizophrenia: A prospective study. Psychiatry Research: Neuroimaging, Vol. 247, p. 42.


    Jakabek, David Yücel, Murat Lorenzetti, Valentina and Solowij, Nadia 2016. An MRI study of white matter tract integrity in regular cannabis users: effects of cannabis use and age. Psychopharmacology, Vol. 233, Issue. 19-20, p. 3627.


    ×

Effect of high-potency cannabis on corpus callosum microstructure

  • S. Rigucci (a1) (a2), T. R. Marques (a2), M. Di Forti (a2), H. Taylor (a2), F. Dell'Acqua (a3), V. Mondelli (a4) (a5), S. Bonaccorso (a2), A. Simmons (a3), A. S. David (a2) (a5), P. Girardi (a1), C. M. Pariante (a4) (a5), R. M. Murray (a2) (a5) and P. Dazzan (a2) (a5)
  • DOI: http://dx.doi.org/10.1017/S0033291715002342
  • Published online: 27 November 2015
Abstract
Background

The use of cannabis with higher Δ9-tetrahydrocannabinol content has been associated with greater risk, and earlier onset, of psychosis. However, the effect of cannabis potency on brain morphology has never been explored. Here, we investigated whether cannabis potency and pattern of use are associated with changes in corpus callosum (CC) microstructural organization, in patients with first-episode psychosis (FEP) and individuals without psychosis, cannabis users and non-users.

Method

The CC of 56 FEP (37 cannabis users) and 43 individuals without psychosis (22 cannabis users) was virtually dissected and segmented using diffusion tensor imaging tractography. The diffusion index of fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity was calculated for each segment.

Results

Across the whole sample, users of high-potency cannabis had higher total CC MD and higher total CC AD than both low-potency users and those who never used (p = 0.005 and p = 0.004, respectively). Daily users also had higher total CC MD and higher total CC AD than both occasional users and those who never used (p = 0.001 and p < 0.001, respectively). However, there was no effect of group (patient/individuals without psychosis) or group x potency interaction for either potency or frequency of use. The within-group analysis showed in fact that the effects of potency and frequency were similar in FEP users and in users without psychosis.

Conclusions

Frequent use of high-potency cannabis is associated with disturbed callosal microstructural organization in individuals with and without psychosis. Since high-potency preparations are now replacing traditional herbal drugs in many European countries, raising awareness about the risks of high-potency cannabis is crucial.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effect of high-potency cannabis on corpus callosum microstructure
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Effect of high-potency cannabis on corpus callosum microstructure
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Effect of high-potency cannabis on corpus callosum microstructure
      Available formats
      ×
Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
*Address for correspondence: S. Rigucci, M.D., Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, Unit of Psychiatry, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy. (Email: s.rigucci@gmail.com)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

J Acosta-Cabronero , GB Williams , G Pengas , PJ Nestor (2010). Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease. Brain 133, 529539.

MAnnett (1970). A classification of hand preference by association analysis. British Journal of Psychology 61, 303321.

DArnone , MTAbou-Saleh , TRBarrick (2006). Diffusion tensor imaging of the corpus callosum in addiction. Neuropsychobiology 54, 107113.

D Arnone , TR Barrick , S Chengappa , CE Mackaya , CA Clark , and MT Abou-Saleh (2008). Corpus callosum damage in heavy marijuana use: preliminary evidence from diffusion tensor tractography and tract-based spatial statistics. NeuroImage 41, 10671074.

PJ Basser , J Matiello , D Le Bihan (1994). Estimation of the effective self-diffusion tensor from the NMR spin echo. Journal of Magnetic Resonance, Series B 103, 247254.

JMBeaulieu , JKriz , JPJulien (2002). Induction of peripherin expression in subsets of brain neurons after lesion injury or cerebral ischemia. Brain Research 946, 153161.

B Bosch , EM Arenaza-Urquijo , L Rami , R Sala-Llonch , C Junqué (2012). Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance. Neurobiology of Aging 33, 6174.

P Brambilla , R Cerini , A Gasparini , A Versace , N Andreone , E Vittorini (2005). Investigation of corpus callosum in schizophrenia with diffusion imaging. Schizophrenia Research 79, 201210.

MS Buchsbaum , J Friedman , BR Buchsbaum , KW Chu , EA Hazlett (2006). Diffusion tensor imaging in schizophrenia. Biological Psychiatry 60, 11811187.

P Casadio , C Fernandes , RM Murray , M Di Forti (2011). Cannabis use in young people: the risk for schizophrenia. Neuroscience and Biobehavioral Reviews 35, 17791787.

M Catani , RJ Howard , S Pajevic , DK Jones (2002). Virtual in vivo interactive dissection of white matter fasciculi in the human brain. NeuroImage 17, 7794.

MCatani , MThiebaut de Schotten (2008). A diffusion tensor imaging tractography atlas for virtual in vivo dissections. Cortex 44, 11051132.

V Cheung , C Cheung , GM McAlonan , Y Deng , JG Wong (2008). A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia. Psychological Medicine 38, 877885.

JCousijn , RWWiers , KRRidderinkhof , Wvan den Brink , DJVeltman , AEGoudriaan (2012). Grey matter alterations associated with cannabis use: results of a VBM study in heavy cannabis users and healthy controls. NeuroImage 59, 38453851.

KL Davis , DG Stewart , JI Friedman , M Buchsbaum , PD Harvey , PR Hof , J Buxbaum , V Haroutunian (2003). White matter changes in schizophrenia: evidence for myelin-related dysfunction. Archives of General Psychiatry 60, 443456.

MD De Bellis , E Van Voorhees , SR Hooper , N Gibler , L Nelson (2008). Diffusion tensor measures of the corpus callosum in adolescents with adolescent onset alcohol use disorders. Alcohol Clinical Experimental Research 32, 395404.

N Dekker , N Schmitz , BD Peters , TA van Amelsvoort , DH Linszen , L de Haan (2010). Cannabis use and callosal white matter structure and integrity in recent-onset schizophrenia. Psychiatry Research 181, 5156.

F Dell'Acqua , A Simmons , SC Williams , M Catani (2013). Can spherical deconvolution provide more information than fiber orientations? Hindrance modulated orientational anisotropy, a true-tract specific index to characterize white matter diffusion. Human Brain Mapping 34, 24642483.

M Di Forti , C Iyegbe , H Sallis , A Kolliakou , MA Falcone , A Paparelli , M Sirianni , C La Cascia , SA Stilo , TR Marques , R Handley , V Mondelli , P Dazzan , C Pariante , AS David , C Morgan , J Powell , RM Murray (2012). Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users. Biological Psychiatry 72, 811816.

M Di Forti , C Morgan , P Dazzan , C Pariante , V Mondelli , TR Marques , R Handley , S Luzi , M Russo , A Paparelli , A Butt , SA Stilo , B Wiffen , J Powell , RM Murray (2009). High-potency cannabis and the risk of psychosis. British Journal of Psychiatry 195, 488491.

TP Freeman , CJ Morgan , C Hindocha , G Schafer , RK Das , HV Curran (2014). Just say ‘know’: how do cannabinoid concentrations influence users’ estimates of cannabis potency and the amount they roll in joints? Addiction 109, 16861694.

JIFriedman , CTang , DCarpenter , MBuchsbaum , JSchmeidler (2008). Diffusion tensor imaging findings in first-episode and chronic schizophrenia patients. American Journal of Psychiatry 165, 10241032.

RGasparotti , PValsecchi , FCarletti , AGalluzzo , RLiserre (2009). Reduced fractional anisotropy of corpus callosum in first-contact, antipsychotic drug-naive patients with schizophrenia. Schizophrenia Research 108, 4148.

JM Gilman , JK Kuster , S Lee , MJ Lee , BW Kim , N Makris , A van der Kouwe , AJ Blood , HC Breiter (2014). Cannabis use is quantitatively associated with nucleus accumbens and amygdala abnormalities in young adult recreational users. Journal of Neuroscience 34, 529538.

SA Gruber , DA Yurgelun-Todd (2005). Neuroimaging of marijuana smokers during inhibitory processing: a pilot investigation. Cognitive Brain Research 23, 107118.

S Haller , L Curtis , M Badan , S Bessero , M Albom , F Chantraine , A Alimenti , KO Lovblad , P Giannakopoulos , M Merlo (2013). Combined grey matter VBM and white matter TBSS analysis in young first episode psychosis patients with and without cannabis consumption. Brain Topography 26, 641647.

L Heng , JA Beverley , H Steiner , KY Tseng (2011). Differential developmental trajectories for CB1 cannabinoid receptor expression in limbic/associative and sensorimotor cortical areas. Synapse 65, 278286.

C Henquet , J Van Os (2008). The coherence of the evidence linking cannabis with psychosis. Psychological Medicine 38, 461462.

CRHjorthøj , AFohlmann , A-MLarsen , MArendt and MNordentoft (2011). Correlations and agreement between delta-9-tetrahydrocannabinol (THC) in blood plasma and timeline follow-back (TLFB)-assisted self-reported use of cannabis of patients with cannabis use disorder and psychotic illness attending the CapOpus randomized clinical trial. Addiction 107, 11231131.

AJames , MHough , SJames , LWinmill , LBurge , SNijhawan , PMMatthews , MZarei (2011). Greater white and grey matter changes associated with early cannabis use in adolescent-onset schizophrenia (AOS). Schizophrenia Research 128, 9197.

DKJones , LDGriffin , DCAlexander , MCatani , MAHorsfield , RHoward , SCWilliams (2002). Spatial normalization and averaging of diffusion tensor MRI sets. NeuroImage 17, 592617.

RAKanaan , JSKim , WEKaufmann , GDPearlson , GJBarker , PKMcGuire (2005). Diffusion tensor imaging in schizophrenia. Biological Psychiatry 58, 921929.

SRKay , AFiszbein , LAOpler (1987). The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261276.

MKubicki , MStyner , SBouix , GGerig , DMarkant (2008). Reduced interhemispheric connectivity in schizophrenia-tractography based segmentation of the corpus callosum. Schizophrenia Research 106, 125131.

MKyriakopoulos , NSVyas , GJBarker , XAChitnis , SFrangou (2008). A diffusion tensor imaging study of white matter in early-onset schizophrenia. Biological Psychiatry 63, 519523.

ALeemans , DKJones (2009). The B-matrix must be rotated when correcting for subject motion in DTI data. Magnetic Resonance Medicine 61, 13361349.

MS Lener , E Wong , CY Tang , W Byne , KE Goldstein , NJ Blair , MM Haznedar , AS New , E Chemerinski , KW Chu , LS Rimsky , LJ Siever , HW Koenigsberg , EA Hazlett (2015). White matter abnormalities in schizophrenia and schizotypal personality disorder. Schizophrenia Bulletin 41, 300310.

V Lorenzetti , DI Lubman , S Whittle , N Solowj , M Yucel (2010). Structural MRI findings in long-term cannabis users: what do we know? Substance Use and Misuse 45, 17871808.

P McGuffin , A Farmer , I Harvey (1991). A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Archives of General Psychiatry 48, 764770.

RG Pertwee (2008). The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. British Journal of Pharmacology 153, 199215.

DJ Potter , P Clark , MB Brown (2008). Potency of delta 9-THC and other cannabinoids in cannabis in England in 2005: implications for psychoactivity and pharmacology. Journal of Forensic Sciences 53, 9094.

LD Selemon , PS Goldman-Rakic (1999). The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biological Psychiatry 45, 1725.

SSShergill , RAKanaan , XAChitnis , OO'Daly , DKJones (2007). A diffusion tensor imaging study of fasciculi in schizophrenia. American Journal of Psychiatry 164, 467473.

SP Singh , JE Cooper , HL Fisher , CJ Tarrant , T Lloyd , J Banjo , S Corfe , P Jones (2005). Determining the chronology and components of psychosis onset: the Nottingham Onset Schedule (NOS). Schizophrenia Research 80, 117130.

M Walterfang , AG Wood , DC Reutens , SJ Wood , J Chen , D Velakoulis , PD McGorry , C Pantelis (2008). Morphology of the corpus callosum at different stages of schizophrenia: cross-sectional study in first-episode and chronic illness. British Journal of Psychiatry 192, 429434.

SF Witelson (1989). Hand and sex differences in the isthmus and genu of the human corpus callosum: a postmortem morphological study. Brain 112, 799835.

SWWoods (2003). Chlorpromazine equivalent doses for the newer atypical antipsychotics. Journal of Clinical Psychiatry 64, 663667.

HYasmin , SAoki , OAbe , YNakata , NHayashi , YMasutani , MGoto , KOhtomo (2009). Tract-specific analysis of white matter pathways in healthy subjects: a pilot study using diffusion tensor MRI. Neuroradiology 51, 831840.

M Yücel , N Solowij , C Respondek , S Whittle , A Fornito , C Pantelis , DI Lubman (2008). Regional brain abnormalities associated with long-term heavy cannabis use. Archives of General Psychiatry 65, 694701.

AZalesky , NSolowij , MYücel , DILubman , MTakagi , IHHarding , VLorenzetti , RWang , KSearle , CPantelis , MSeal (2012). Effect of long-term cannabis use on axonal fibre connectivity. Brain 135, 22452255.

M Zarei , H Johansen-Berg , S Smith , O Ciccarelli , AJ Thompson (2006). Functional anatomy of interhemispheric cortical connections in the human brain. Journal of Anatomy 209, 311320.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
UNKNOWN
Supplementary Materials

Rigucci supplementary material
Rigucci supplementary material 1

 Unknown (32 KB)
32 KB