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Erythrocyte membrane cation carrier in depressive illness1

  • G. J. Naylor (a1), D. A. T. Dick (a1), E. G. Dick (a1), D. Le Poidevin (a1) and S. F. Whyte (a1)...

Erythrocyte sodium concentration, potassium concentration, Na-K ATPase activity, and ouabain sensitive potassium influx were determined in female inpatients suffering from a depressive illness. In most patients the biochemical values were also determined shortly before the patient's discharge from hospital. The Na-K ATPase and the ouabain sensitive potassium influx increased significantly with improvement in the depressive mood rating.

Corresponding author
2 Address for correspondence: Dr. G. J. Naylor, Department of Psychiatry, University of Dundee, Dundee, DD1 4HN.
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These studies were supported by a grant to G.J.N. and D.A.T.D. by the Scottish Hospitals Endowment Research Trust.

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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

A. Coppen , and D. M. Shaw (1963). Mineral metabolism in melancholia. British Medical Journal, 2, 14391444.

A. Coppan , D. M. Shaw , and A. Mangoni (1962). Total exchangeable sodium in depressive illness. British Medical Journal, 2, 295298.

J. R. Cox , R. E. Pearson , and C. J. Speight (1971). Changes in sodium, potassium and body fluid spaces in depression and dementia. Gerontologia Clinica, 13, 233245.

D. A. T. Dick , E. G. Dick , and D. C. Tosteson (1969). Inhibition of adenosine triphosphatase in sheep red cell membranes by oxidized glutathione. Journal of General Physiology, 54, 123133.

J. L. Gibbons (1964). Cortisol secretion rate in depressive illness. Archives of General Psychiatry, 10, 572575.

G. J. Naylor , H. B. McNamee , and J. P. Moody (1971). Changes in erythrocyte sodium and potassium on recovery from a depressive illness. British Journal of Psychiatry, 118, 219223.

S. R. Platman , R. R. Fieve , and R. N. Pierson Jr. (1970). Effect of mood and lithium carbonate on total body potassium. Archives of General Psychiatry, 22, 297300.

J. J. Schildkraut , and S. S. Kety (1967). Biogenic amines and emotion. Science, 156, 2137.

M. M. Singh (1970). A unifying hypothesis on the biochemical basis of affective disorder. Psychiatric Quarterly, 44, 706724.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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