Boulos, Laura-Joy Darcq, Emmanuel and Kieffer, Brigitte Lina 2017. Translating the Habenula—From Rodents to Humans. Biological Psychiatry, Vol. 81, Issue. 4, p. 296.
Kaye, Alfred and Ross, David A. 2017. The Habenula: Darkness, Disappointment, and Depression. Biological Psychiatry, Vol. 81, Issue. 4, p. e27.
Ahumada-Galleguillos, Patricio Lemus, Carmen G. Díaz, Eugenia Osorio-Reich, María Härtel, Steffen and Concha, Miguel L. 2016. Directional asymmetry in the volume of the human habenula. Brain Structure and Function,
Bernstein, Hans-Gert Hildebrandt, Jens Dobrowolny, Henrik Steiner, Johann Bogerts, Bernhard and Pahnke, Jens 2016. Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula. Schizophrenia Research, Vol. 177, Issue. 1-3, p. 52.
Bernstein, Hans-Gert Ortmann, Anna Dobrowolny, Henrik Steiner, Johann Brisch, Ralf Gos, Tomasz and Bogerts, Bernhard 2016. Bilaterally reduced claustral volumes in schizophrenia and major depressive disorder: a morphometric postmortem study. European Archives of Psychiatry and Clinical Neuroscience, Vol. 266, Issue. 1, p. 25.
Bogerts, Bernhard and Walter, Martin 2016. Psychiatrie, Psychosomatik, Psychotherapie.
Ely, Benjamin A. Xu, Junqian Goodman, Wayne K. Lapidus, Kyle A. Gabbay, Vilma and Stern, Emily R. 2016. Resting-state functional connectivity of the human habenula in healthy individuals: Associations with subclinical depression. Human Brain Mapping, Vol. 37, Issue. 7, p. 2369.
Hétu, Sébastien Luo, Yi Saez, Ignacio D'Ardenne, Kimberlee Lohrenz, Terry and Montague, P. Read 2016. Asymmetry in functional connectivity of the human habenula revealed by high-resolution cardiac-gated resting state imaging. Human Brain Mapping, Vol. 37, Issue. 7, p. 2602.
Huie, David Aronson, Joshua P. and Eskandar, Emad N. 2016. Neuromodulation in Psychiatry.
Kim, Joo-won Naidich, Thomas P. Ely, Benjamin A. Yacoub, Essa De Martino, Federico Fowkes, Mary E. Goodman, Wayne K. and Xu, Junqian 2016. Human habenula segmentation using myelin content. NeuroImage, Vol. 130, p. 145.
Lawson, R P Nord, C L Seymour, B Thomas, D L Dayan, P Pilling, S and Roiser, J P 2016. Disrupted habenula function in major depression. Molecular Psychiatry,
McInerney, Shane J. Giacobbe, Peter Cyriac, Anna and Kennedy, Sidney H. 2016. Neuromodulation in Psychiatry.
Sartorius, Alexander Demirakca, Traute Böhringer, Andreas Clemm von Hohenberg, Christian Aksay, Suna Su Bumb, Jan Malte Kranaster, Laura and Ende, Gabriele 2016. Electroconvulsive therapy increases temporal gray matter volume and cortical thickness. European Neuropsychopharmacology, Vol. 26, Issue. 3, p. 506.
Schmidt, Frank M. Schindler, Stephanie Adamidis, Melanie Strauß, Maria Tränkner, Anja Trampel, Robert Walter, Martin Hegerl, Ulrich Turner, Robert Geyer, Stefan and Schönknecht, Peter 2016. Habenula volume increases with disease severity in unmedicated major depressive disorder as revealed by 7T MRI. European Archives of Psychiatry and Clinical Neuroscience,
Benarroch, Eduardo E. 2015. Habenula. Neurology, Vol. 85, Issue. 11, p. 992.
Brisch, Ralf Bielau, Hendrik Saniotis, Arthur Wolf, Rainer Bogerts, Bernhard Krell, Dieter Steiner, Johann Braun, Katharina Krzyżanowska, Marta Krzyżanowski, Maciej Jankowski, Zbigniew Kaliszan, Michał Bernstein, Hans-Gert and Gos, Tomasz 2015. Calretinin and parvalbumin in schizophrenia and affective disorders: a mini-review, a perspective on the evolutionary role of calretinin in schizophrenia, and a preliminary post-mortem study of calretinin in the septal nuclei. Frontiers in Cellular Neuroscience, Vol. 9,
Broms, Jonas Antolin-Fontes, Beatriz Tingström, Anders and Ibañez-Tallon, Ines 2015. Conserved expression of the GPR151 receptor in habenular axonal projections of vertebrates. Journal of Comparative Neurology, Vol. 523, Issue. 3, p. 359.
Carceller-Sindreu, M. de Diego-Adeliño, J. Serra-Blasco, M. Vives-Gilabert, Y. Martí;n-Blanco, A. Puigdemont, D. Álvarez, E. Pérez, V. and Portella, M.J. 2015. Volumetric MRI study of the habenula in first episode, recurrent and chronic major depression. European Neuropsychopharmacology, Vol. 25, Issue. 11, p. 2015.
Cleary, Daniel R. Ozpinar, Alp Raslan, Ahmed M. and Ko, Andrew L. 2015. Deep brain stimulation for psychiatric disorders: where we are now. Neurosurgical Focus, Vol. 38, Issue. 6, p. E2.
Han, Ling-Na Zhang, Li Li, Li-Bo Sun, Yi-Na Wang, Yong Chen, Li Guo, Yuan Zhang, Yu-Ming Zhang, Qiao-Jun and Liu, Jian 2015. Activation of serotonin2C receptors in the lateral habenular nucleus increases the expression of depression-related behaviors in the hemiparkinsonian rat. Neuropharmacology, Vol. 93, p. 68.
The habenular complex is composed of important relay nuclei linking the limbic forebrain to the midbrain and brain stem nuclei. Based on clinical observations, experiments with animals and theoretical considerations, it has been speculated that this brain area might be involved in psychiatric diseases (i.e. schizophrenia and depression). However, evidence in favour of this hypothesis is still lacking because the human habenular complex has rarely been studied with regard to mental illness.
We examined habenular volumes in post-mortem brains of 17 schizophrenia patients, 14 patients with depression (six patients with major depression and eight patients with bipolar depression) and 13 matched controls. We further determined the neuronal density, cell number and cell area of the medial habenular nuclei of the same cohorts using a counting box and a computer-assisted instrument.
Significantly reduced habenular volumes of the medial and lateral habenula were estimated in depressive patients in comparison to normal controls and schizophrenia patients. We also found a reduction in neuronal cell number and cell area in depressive patients for the right side compared to controls and schizophrenia patients. No such changes were seen in schizophrenia.
Our anatomical data argue against prominent structural alterations of the habenular nuclei in schizophrenia but demonstrate robust alterations in depressive patients. We are currently applying immunohistochemical markers to better characterize neuronal subpopulations of this brain region in schizophrenia and depression.
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