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Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder

  • K. E. Lewandowski (a1), B. M. Cohen (a1) and D. Öngur (a1)

Neurocognitive dysfunction in schizophrenia (SZ), bipolar (BD) and related disorders represents a core feature of these illnesses, possibly a marker of underlying pathophysiology. Substantial overlap in domains of neuropsychological deficits has been reported among these disorders after illness onset. However, it is unclear whether deficits follow the same longitudinal pre- and post-morbid course across diagnoses. We examine evidence for neurocognitive dysfunction as a core feature of all idiopathic psychotic illnesses, and trace its evolution from pre-morbid and prodromal states through the emergence of overt psychosis and into chronic illness in patients with SZ, BD and related disorders.


Articles reporting on neuropsychological functioning in patients with SZ, BD and related disorders before and after illness onset were reviewed. Given the vast literature on these topics and the present focus on cross-diagnostic comparisons, priority was given to primary data papers that assessed cross-diagnostic samples and recent meta-analyses.


Patients with SZ exhibit dysfunction preceding the onset of illness, which becomes more pronounced in the prodrome and early years following diagnosis, then settles into a stable pattern. Patients with BD generally exhibit typical cognitive development pre-morbidly, but demonstrate deficits by first episode that are amplified with worsening symptoms and exacerbations.


Neuropsychological deficits represent a core feature of SZ and BD; however, their onset and progression differ between diagnostic groups. A lifetime perspective on the evolution of neurocognitive deficits in SZ and BD reveals distinct patterns, and may provide a useful guide to the examination of the pathophysiological processes underpinning these functions across disorders.

Corresponding author
*Address for correspondence: Dr K. E. Lewandowski, AB347, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. (Email:
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Aloia MS, Gourovitch ML, Weinberger DR, Goldberg TE (1996). An investigation of semantic space in patients with schizophrenia. Journal of the International Neuropsychological Society 2, 267273.
Altshuler LL, Ventura J, van Gorp WG, Green MF, Theberge DC, Mintz J (2004). Neurocognitive function in clinically stable men with bipolar I disorder or schizophrenia and normal control subjects. Biological Psychiatry 56, 560569.
Andreasen NC (1999). A unitary model of schizophrenia. Bleuler's ‘Fragmented Phrene’ as schizencephaly. Archives of General Psychiatry 56, 781787.
Andreasen NC, Flaum M, Swayze VW, Tyrrell G 2nd, Arndt S (1990). Positive and negative symptoms in schizophrenia. A critical reappraisal. Archives of General Psychiatry 47, 615621.
Asarnow RF, MacCrimmon DJ (1978). Residual performance deficit in clinically remitted schizophrenics: a marker of schizophrenia? Journal of Abnormal Psychology 87, 597608.
Balanza-Martinez V, Tabares-Seisdedos R, Selva-Vera G, Martinez-Aran A, Torrent C, Salazar-Fraile J, Leal-Cercos C, Vieta E, Gomez-Beneyto M (2005). Persistent cognitive dysfunctions in bipolar I disorder and schizophrenic patients: a 3-year follow-up study. Psychotherapy and Psychosomatics 74, 113119.
Barrett SL, Mulholland CC, Cooper SJ, Rushe TM (2009). Patterns of neurocognitive impairment in first-episode bipolar disorder and schizophrenia. British Journal of Psychiatry 195, 6772.
Bearden CE, Jawad AF, Lynch DR, Sokol S, Kanes SJ, McDonald-McGinn DM, Saitta SC, Harris SE, Moss E, Wang PP, Zackai E, Emanuel BS, Simon TJ (2004). Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome. American Journal of Psychiatry 161, 17001702.
Becker HE, Nieman DH, Wiltink S, Dingemans PM, van de Fliert JR, Velthorst E, de Haan L, van Amelsvoort TA, Linszen DH (2010). Neurocognitive functioning before and after the first psychotic episode: does psychosis result in cognitive deterioration? Psychological Medicine. Published online: 5 February 2010. doi:10.1017/S0033291710000048.
Berman I, Viegner B, Merson A, Allan E, Pappas D, Green AI (1997). Differential relationships between positive and negative symptoms and neuropsychological deficits in schizophrenia. Schizophrenia Research 25, 110.
Bilder RM, Reiter G, Bates J, Lencz T, Szeszko P, Goldman RS, Robinson D, Lieberman JA, Kane JM (2006). Cognitive development in schizophrenia: follow-back from the first episode. Journal of Clinical and Experimental Neuropsychology 28, 270282.
Brazo P, Marie RM, Halbecq I, Benali K, Segard L, Delamillieure P, Langlois-Thery S, Van Der Elst A, Thibaut F, Petit M, Dollfus S (2002). Cognitive patterns in subtypes of schizophrenia. European Psychiatry 17, 155162.
Brickman AM, Buchsbaum MS, Bloom R, Bokhoven P, Paul-Odouard R, Haznedar MM, Dahlman KL, Hazlett EA, Aronowitz J, Heath D, Shihabuddin L (2004). Neuropsychological functioning in first-break, never-medicated adolescents with psychosis. Journal of Nervous and Mental Disease 192, 615622.
Cannon M, Walsh E, Hollis C, Kargin M, Taylor E, Murray RM, Jones PB (2001). Predictors of later schizophrenia and affective psychosis among attendees at a child psychiatry department. British Journal of Psychiatry 178, 420426.
Carter CS, Barch DM (2007). Cognitive neuroscience-based approaches to measuring and improving treatment effects on cognition in schizophrenia: the CNTRICS initiative. Schizophrenia Bulletin 33, 11311137.
Casey BJ, Giedd JN, Thomas KM (2000). Structural and functional brain development and its relation to cognitive development. Biological Psychology 54, 241257.
Caspi A, Reichenberg A, Weiser M, Rabinowitz J, Kaplan Z, Knobler H, Davidson-Sagi N, Davidson M (2003). Cognitive performance in schizophrenia patients assessed before and following the first psychotic episode. Schizophrenia Research 65, 8794.
Chugani H, Chugani D (1997). Positron emission tomography studies of developing brain. In Neurodevelopment and Adult Psychopathology (ed. Keshavan M. and Murray R.), pp. 93–103. Cambridge University Press: Cambridge, UK.
Cohen JD, Braver TS, O'Reilly RC (1996). A computational approach to prefrontal cortex, cognitive control and schizophrenia: recent developments and current challenges. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 351, 15151527.
Cornblatt BA, Erlenmeyer-Kimling L (1985). Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. Journal of Abnormal Psychology 94, 470486.
Cornblatt BA, Lenzenweger MF, Dworkin RH, Erlenmeyer-Kimling L (1992). Childhood attentional dysfunctions predict social deficits in unaffected adults at risk for schizophrenia. British Journal of Psychiatry 18 (Suppl.), 5964.
Cornblatt BA, Lenzenweger MF, Erlenmeyer-Kimling L (1989). The continuous performance test, identical pairs version: II. Contrasting attentional profiles in schizophrenic and depressed patients. Psychiatry Research 29, 6585.
Craddock N, O'Donovan MC, Owen MJ (2006). Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophrenia Bulletin 32, 9–16.
Cunningham WR (1987). Intellectual abilities and age. Annual Review of Gerontology and Geriatrics 7, 117134.
Cvetic T, Vukovic O (2006). Cognitive deficit in schizophrenia: comparative analysis of positive and negative subtype and predictors of positive subtype. Psychiatria Danubina 18, 4–11.
Davidson M, Reichenberg A, Rabinowitz J, Weiser M, Kaplan Z, Mark M (1999). Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents. American Journal of Psychiatry 156, 13281335.
Denicoff KD, Ali SO, Mirsky AF, Smith-Jackson EE, Leverich GS, Duncan CC, Connell EG, Post RM (1999). Relationship between prior course of illness and neuropsychological functioning in patients with bipolar disorder. Journal of Affective Disorders 56, 6773.
Depp CA, Moore DJ, Sitzer D, Palmer BW, Eyler LT, Roesch S, Lebowitz BD, Jeste DV (2007). Neurocognitive impairment in middle-aged and older adults with bipolar disorder: comparison to schizophrenia and normal comparison subjects. Journal of Affective Disorders 101, 201209.
Dickerson F, Boronow JJ, Stallings C, Origoni AE, Cole SK, Yolken RH (2004). Cognitive functioning in schizophrenia and bipolar disorder: comparison of performance on the Repeatable Battery for the Assessment of Neuropsychological Status. Psychiatry Research 129, 4553.
Dickinson D, Gold JM (2008). Less unique variance than meets the eye: overlap among traditional neuropsychological dimensions in schizophrenia. Schizophrenia Bulletin 34, 423434.
Dickinson D, Iannone VN, Wilk CM, Gold JM (2004). General and specific cognitive deficits in schizophrenia. Biological Psychiatry 55, 826833.
Dickinson D, Ragland JD, Calkins ME, Gold JM, Gur RC (2006). A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis. Schizophrenia Research 85, 2029.
Dickinson D, Ragland JD, Gold JM, Gur RC (2008). General and specific cognitive deficits in schizophrenia: Goliath defeats David? Biological Psychiatry 64, 823827.
Ditman T, Kuperberg GR (2005). A source-monitoring account of auditory verbal hallucinations in patients with schizophrenia. Harvard Review of Psychiatry 13, 280299.
Dixon T, Kravariti E, Frith C, Murray RM, McGuire PK (2004). Effect of symptoms on executive function in bipolar illness. Psychological Medicine 34, 811821.
Donaldson S, Goldstein LH, Landau S, Raymont V, Frangou S (2003). The Maudsley Bipolar Disorder Project: the effect of medication, family history, and duration of illness on IQ and memory in bipolar I disorder. Journal of Clinical Psychiatry 64, 8693.
Drane DL, Meador KJ (1996). Epilepsy, anticonvulsant drugs and cognition. Baillière's Clinical Neurology 5, 877885.
Elie D, Poirier M, Chianetta J, Durand M, Gregoire C, Grignon S (2009). Cognitive effects of antipsychotic dosage and polypharmacy: a study with the BACS in patients with schizophrenia and schizoaffective disorder. Journal of Psychopharmacology. Published online: 22 January 2009. doi:10.1177/0269881108100777.
Elliott R, McKenna PJ, Robbins TW, Sahakian BJ (1995). Neuropsychological evidence for frontostriatal dysfunction in schizophrenia. Psychological Medicine 25, 619630.
Engelsmann F, Katz J, Ghadirian AM, Schachter D (1988). Lithium and memory: a long-term follow-up study. Journal of Clinical Psychopharmacology 8, 207212.
Erlenmeyer-Kimling L (2000). Neurobehavioral deficits in offspring of schizophrenic parents: liability indicators and predictors of illness. American Journal of Medical Genetics 97, 6571.
Erlenmeyer-Kimling L, Rock D, Roberts SA, Janal M, Kestenbaum C, Cornblatt B, Adamo UH, Gottesman II (2000). Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: the New York High-Risk Project. American Journal of Psychiatry 157, 14161422.
Fuller R, Nopoulos P, Arndt S, O'Leary D, Ho BC, Andreasen NC (2002). Longitudinal assessment of premorbid cognitive functioning in patients with schizophrenia through examination of standardized scholastic test performance. American Journal of Psychiatry 159, 11831189.
Genderson MR, Dickinson D, Diaz-Asper CM, Egan MF, Weinberger DR, Goldberg TE (2007). Factor analysis of neurocognitive tests in a large sample of schizophrenic probands, their siblings, and healthy controls. Schizophrenia Research 94, 231239.
Giedd JN, Jeffries NO, Blumenthal J, Castellanos FX, Vaituzis AC, Fernandez T, Hamburger SD, Liu H, Nelson J, Bedwell J, Tran L, Lenane M, Nicolson R, Rapoport JL (1999). Childhood-onset schizophrenia: progressive brain changes during adolescence. Biological Psychiatry 46, 892898.
Glahn DC, Bearden CE, Barguil M, Barrett J, Reichenberg A, Bowden CL, Soares JC, Velligan DI (2007). The neurocognitive signature of psychotic bipolar disorder. Biological Psychiatry 62, 910916.
Glahn DC, Bearden CE, Cakir S, Barrett JA, Najt P, Serap Monkul E, Maples N, Velligan DI, Soares JC (2006). Differential working memory impairment in bipolar disorder and schizophrenia: effects of lifetime history of psychosis. Bipolar Disorders 8, 117123.
Gold JM, Harvey PD (1993). Cognitive deficits in schizophrenia. Psychiatric Clinics of North America 16, 295312.
Gold S, Arndt S, Nopoulos P, O'Leary DS, Andreasen NC (1999). Longitudinal study of cognitive function in first-episode and recent-onset schizophrenia. American Journal of Psychiatry 156, 13421348.
Goldberg JF, Burdick KE (2001). Cognitive side effects of anticonvulsants. Journal of Clinical Psychiatry 62 (Suppl. 14), 2733.
Goldberg TE, Hyde TM, Kleinman JE, Weinberger DR (1993). Course of schizophrenia: neuropsychological evidence for a static encephalopathy. Schizophrenia Bulletin 19, 797804.
Goldman-Rakic P (1994). Working memory dysfunction in schizophrenia. Journal of Neuropsychiatry and Clinical Neuroscience 6, 348357.
Gonzalez-Blanch C, Alvarez-Jimenez M, Rodriguez-Sanchez JM, Perez-Iglesias R, Vazquez-Barquero JL, Crespo-Facorro B (2006). Cognitive functioning in the early course of first-episode schizophrenia spectrum disorders: timing and patterns. European Archives of Psychiatry and Clinical Neuroscience 256, 364371.
Green M (1996). What are the functional consequences of neurocognitive deficits in schizophrenia? American Journal of Psychiatry 153, 321330.
Green MF, Kern RS, Braff DL, Mintz J (2000). Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the ‘right stuff’? Schizophrenia Bulletin 26, 119136.
Green MF, Nuechterlein KH, Gold JM, Barch DM, Cohen J, Essock S, Fenton WS, Frese F, Goldberg TE, Heaton RK, Keefe RS, Kern RS, Kraemer H, Stover E, Weinberger DR, Zalcman S, Marder SR (2004). Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biological Psychiatry 56, 301307.
Gruber SA, Rosso IM, Yurgelun-Todd D (2008). Neuropsychological performance predicts clinical recovery in bipolar patients. Journal of Affective Disorders 105, 253260.
Harvey PD (2009). When does cognitive decline occur in the period prior to the first episode of schizophrenia? Psychiatry (Edgmont) 6, 1214.
Harvey PD, Hassman H, Mao L, Gharabawi GM, Mahmoud RA, Engelhart LM (2007). Cognitive functioning and acute sedative effects of risperidone and quetiapine in patients with stable bipolar I disorder: a randomized, double-blind, crossover study. Journal of Clinical Psychiatry 68, 11861194.
Harvey PD, Keefe RS (2001). Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment. American Journal of Psychiatry 158, 176184.
Harvey PD, Keefe RS, Moskowitz J, Putnam KM, Mohs RC, Davis KL (1990). Attentional markers of vulnerability to schizophrenia: performance of medicated and unmedicated patients and normals. Psychiatry Research 33, 179188.
Hawkins KA, Addington J, Keefe RS, Christensen B, Perkins DO, Zipurksy R, Woods SW, Miller TJ, Marquez E, Breier A, McGlashan TH (2004). Neuropsychological status of subjects at high risk for a first episode of psychosis. Schizophrenia Research 67, 115122.
Hawkins KA, Keefe RS, Christensen BK, Addington J, Woods SW, Callahan J, Zipursky RB, Perkins DO, Tohen M, Breier A, McGlashan TH (2008). Neuropsychological course in the prodrome and first episode of psychosis: findings from the PRIME North America Double Blind Treatment Study. Schizophrenia Research 105, 19.
Heaton RK, Gladsjo JA, Palmer BW, Kuck J, Marcotte TD, Jeste DV (2001). Stability and course of neuropsychological deficits in schizophrenia. Archives of General Psychiatry 58, 2432.
Heckers S (2008). Making progress in schizophrenia research. Schizophrenia Bulletin 34, 591594.
Heinrichs RW, Ammari N, McDermid Vaz S, Miles AA (2008). Are schizophrenia and schizoaffective disorder neuropsychologically distinguishable? Schizophrenia Research 99, 149154.
Heinrichs RW, Zakzanis KK (1998). Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 12, 426445.
Henry JC, van Amelsvoort T, Morris RG, Owen MJ, Murphy DG, Murphy KC (2002). An investigation of the neuropsychological profile in adults with velo-cardio-facial syndrome (VCFS). Neuropsychologia 40, 471478.
Hill SK, Ragland JD, Gur RC, Gur RE (2001). Neuropsychological differences among empirically derived clinical subtypes of schizophrenia. Neuropsychology 15, 492501.
Hoff AL, Svetina C, Shields G, Stewart J, DeLisi LE (2005). Ten year longitudinal study of neuropsychological functioning subsequent to a first episode of schizophrenia. Schizophrenia Research 78, 2734.
Holmes MK, Erickson K, Luckenbaugh DA, Drevets WC, Bain EE, Cannon DM, Snow J, Sahakian BJ, Manji HK, Zarate Jr. CA (2008). A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression. Bipolar Disorders 10, 806815.
Holt DJ, Titone D, Long LS, Goff DC, Cather C, Rauch SL, Judge A, Kuperberg GR (2006). The misattribution of salience in delusional patients with schizophrenia. Schizophrenia Research 83, 247256.
Jahshan C, Heaton RK, Golshan S, Cadenhead KS (2010). Course of neurocognitive deficits in the prodrome and first episode of schizophrenia. Neuropsychology 24, 109120.
Jernigan TL, Trauner DA, Hesselink JR, Tallal PA (1991). Maturation of human cerebrum observed in vivo during adolescence. Brain 114, 20372049.
Johnstone EC, Ebmeier KP, Miller P, Owens DG, Lawrie SM (2005). Predicting schizophrenia: findings from the Edinburgh High-Risk Study. British Journal of Psychiatry 186, 1825.
Jones P, Rodgers B, Murray R, Marmot M (1994). Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet 344, 13981402.
Keefe RS, Bilder RM, Davis SM, Harvey PD, Palmer BW, Gold JM, Meltzer HY, Green MF, Capuano G, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Davis CE, Hsiao JK, Lieberman JA (2007). Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial. Archives of General Psychiatry 64, 633647.
Keefe RS, Bilder RM, Harvey PD, Davis SM, Palmer BW, Gold JM, Meltzer HY, Green MF, Miller DD, Canive JM, Adler LW, Manschreck TC, Swartz M, Rosenheck R, Perkins DO, Walker TM, Stroup TS, McEvoy JP, Lieberman JA (2006 a). Baseline neurocognitive deficits in the CATIE schizophrenia trial. Neuropsychopharmacology 31, 20332046.
Keefe RS, Perkins DO, Gu H, Zipursky RB, Christensen BK, Lieberman JA (2006 b). A longitudinal study of neurocognitive function in individuals at-risk for psychosis. Schizophrenia Research 88, 2635.
Keefe RS, Silva SG, Perkins DO, Lieberman JA (1999). The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis. Schizophrenia Bulletin 25, 201222.
Kendler KS, Karkowski LM, Walsh D (1998). The structure of psychosis: latent class analysis of probands from the Roscommon Family Study. Archives of General Psychiatry 55, 492499.
Kerns JG, Nuechterlein KH, Braver TS, Barch DM (2008). Executive functioning component mechanisms and schizophrenia. Biological Psychiatry 64, 2633.
Kremen WS, Lyons MJ, Boake C, Xian H, Jacobson KC, Waterman B, Eisen SA, Goldberg J, Faraone SV, Tsuang MT (2006). A discordant twin study of premorbid cognitive ability in schizophrenia. Journal of Clinical and Experimental Neuropsychology 28, 208224.
Kuperberg G, Heckers S (2000). Schizophrenia and cognitive function. Current Opinion in Neurobiology 10, 205210.
Kurtz MM, Gerraty RT (2009). A meta-analytic investigation of neurocognitive deficits in bipolar illness: profile and effects of clinical state. Neuropsychology 23, 551562.
Kutcher S, Robertson HA, Bird D (1998). Premorbid functioning in adolescent onset bipolar I disorder: a preliminary report from an ongoing study. Journal of Affective Disorders 51, 137144.
Larsen L, Hartmann P, Nyborg H (2008). The stability of general intelligence from early adulthood to middle-age. Intelligence 36, 2934.
Leeson VC, Barnes TR, Harrison M, Matheson E, Harrison I, Mutsatsa SH, Ron MA, Joyce EM (2010). The relationship between IQ, memory, executive function, and processing speed in recent-onset psychosis: 1-year stability and clinical outcome. Schizophrenia Bulletin 36, 400409.
Leeson VC, Barnes TR, Hutton SB, Ron MA, Joyce EM (2009). IQ as a predictor of functional outcome in schizophrenia: a longitudinal, four-year study of first-episode psychosis. Schizophrenia Research 107, 5560.
Lenzenweger M, Dworkin R (1998). Origins and Development of Schizophrenia: Advances in Experimental Psychopathology. American Psychological Association: Washington, DC.
Lewandowski KE, Shashi V, Berry PM, Kwapil TR (2007). Schizophrenic-like neurocognitive deficits in children and adolescents with 22q11 deletion syndrome. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 144B, 2736.
Luck SJ, Gold JM (2008). The construct of attention in schizophrenia. Biologial Psychiatry 64, 3439.
Malmberg A, Lewis G, David A, Allebeck P (1998). Premorbid adjustment and personality in people with schizophrenia. British Journal of Psychiatry 172, 308313; discussion 314–315.
Marenco S, Weinberger DR (2000). The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave. Development and Psychopathology 12, 501527.
Martinez-Aran A, Torrent C, Tabares-Seisdedos R, Salamero M, Daban C, Balanza-Martinez V, Sanchez-Moreno J, Manuel Goikolea J, Benabarre A, Colom F, Vieta E (2008). Neurocognitive impairment in bipolar patients with and without history of psychosis. Journal of Clinical Psychiatry 69, 233239.
McClellan J, Prezbindowski A, Breiger D, McCurry C (2004). Neuropsychological functioning in early onset psychotic disorders. Schizophrenia Research 68, 2126.
McGrath J, Chapple B, Wright M (2001). Working memory in schizophrenia and mania: correlation with symptoms during the acute and subacute phases. Acta Psychiatrica Scandinavica 103, 181188.
McIntosh AM, Harrison LK, Forrester K, Lawrie SM, Johnstone EC (2005). Neuropsychological impairments in people with schizophrenia or bipolar disorder and their unaffected relatives. British Journal of Psychiatry 186, 378385.
Mesholam-Gately RI, Giuliano AJ, Goff KP, Faraone SV, Seidman LJ (2009). Neurocognition in first-episode schizophrenia: a meta-analytic review. Neuropsychology 23, 315336.
Meyer SE, Carlson GA, Wiggs EA, Martinez PE, Ronsaville DS, Klimes-Dougan B, Gold PW, Radke-Yarrow M (2004). A prospective study of the association among impaired executive functioning, childhood attentional problems, and the development of bipolar disorder. Development and Psychopathology 16, 461476.
Mojtabai R, Bromet EJ, Harvey PD, Carlson GA, Craig TJ, Fennig S (2000). Neuropsychological differences between first-admission schizophrenia and psychotic affective disorders. American Journal of Psychiatry 157, 14531460.
Mur M, Portella MJ, Martinez-Aran A, Pifarre J, Vieta E (2008). Long-term stability of cognitive impairment in bipolar disorder: a 2-year follow-up study of lithium-treated euthymic bipolar patients. Journal of Clinical Psychiatry 69, 712719.
Murphy FC, Sahakian BJ (2001). Neuropsychology of bipolar disorder. British Journal of Psychiatry. Supplement 178, s120s127.
Murray RM, Sham P, Van Os J, Zanelli J, Cannon M, McDonald C (2004). A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophrenia Research 71, 405416.
Nehra R, Chakrabarti S, Pradhan BK, Khehra N (2006). Comparison of cognitive functions between first- and multi-episode bipolar affective disorders. Journal of Affective Disorders 93, 185192.
Nieuwenstein MR, Aleman A, de Haan EH (2001). Relationship between symptom dimensions and neurocognitive functioning in schizophrenia: a meta-analysis of WCST and CPT studies. Wisconsin Card Sorting Test. Continuous Performance Test. Journal of Psychiatric Research 35, 119125.
Orzack MH, Kornetsky C (1966). Attention dysfunction in chronic schizophrenia. Archives of General Psychiatry 14, 323326.
Orzack MH, Kornetsky C (1971). Environmental and familial predictors of attention behavior in chronic schizophrenics. Journal of Psychiatric Research 9, 2129.
Osler M, Lawlor DA, Nordentoft M (2007). Cognitive function in childhood and early adulthood and hospital admission for schizophrenia and bipolar disorders in Danish men born in 1953. Schizophrenia Research 92, 132141.
Osuji IJ, Cullum CM (2005). Cognition in bipolar disorder. Psychiatric Clinics of North America 28, 427441.
Pachet AK, Wisniewski AM (2003). The effects of lithium on cognition: an updated review. Psychopharmacology 170, 225234.
Park S, Holzman PS (1992). Schizophrenics show spatial working memory deficits. Archives of General Psychiatry 49, 975982.
Pukrop R, Schultze-Lutter F, Ruhrmann S, Brockhaus-Dumke A, Tendolkar I, Bechdolf A, Matuschek E, Klosterkotter J (2006). Neurocognitive functioning in subjects at risk for a first episode of psychosis compared with first- and multiple-episode schizophrenia. Journal of Clinical and Experimental Neuropsychology 28, 13881407.
Quackenbush D, Kutcher S, Robertson HA, Boulos C, Chaban P (1996). Premorbid and postmorbid school functioning in bipolar adolescents: description and suggested academic interventions. Canadian Journal of Psychiatry 41, 1622.
Reichenberg A, Caspi A, Harrington H, Houts R, Keefe RS, Murray RM, Poulton R, Moffitt TE (2010). Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: a 30-year study. American Journal of Psychiatry 167, 160169.
Reichenberg A, Harvey PD, Bowie CR, Mojtabai R, Rabinowitz J, Heaton RK, Bromet E (2009). Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophrenia Bulletin 35, 10221029.
Reichenberg A, Weiser M, Caspi A, Knobler HY, Lubin G, Harvey PD, Rabinowitz J, Davidson M (2006). Premorbid intellectual functioning and risk of schizophrenia and spectrum disorders. Journal of Clinical and Experimental Neuropsychology 28, 193207.
Reichenberg A, Weiser M, Rabinowitz J, Caspi A, Schmeidler J, Mark M, Kaplan Z, Davidson M (2002). A population-based cohort study of premorbid intellectual, language, and behavioral functioning in patients with schizophrenia, schizoaffective disorder, and nonpsychotic bipolar disorder. American Journal of Psychiatry 159, 20272035.
Reichenberg A, Weiser M, Rapp MA, Rabinowitz J, Caspi A, Schmeidler J, Knobler HY, Lubin G, Nahon D, Harvey PD, Davidson M (2005). Elaboration on premorbid intellectual performance in schizophrenia: premorbid intellectual decline and risk for schizophrenia. Archives of General Psychiatry 62, 12971304.
Riley EM, McGovern D, Mockler D, Doku VC, O'Ceallaigh S, Fannon DG, Tennakoon L, Santamaria M, Soni W, Morris RG, Sharma T (2000). Neuropsychological functioning in first-episode psychosis – evidence of specific deficits. Schizophrenia Research 43, 4755.
Robinson LJ, Ferrier IN (2006). Evolution of cognitive impairment in bipolar disorder: a systematic review of cross-sectional evidence. Bipolar Disorders 8, 103116.
Robinson LJ, Thompson JM, Gallagher P, Goswami U, Young AH, Ferrier IN, Moore PB (2006). A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. Journal of Affective Disorders 93, 105115.
Rosmark B, Osby U, Engelbrektson K, Nyman H (1999). Stability of performance on neuropsychological tests in patients with schizophrenia. European Archives of Psychiatry and Clinical Neuroscience 249, 299304.
Rossi A, Arduini L, Daneluzzo E, Bustini M, Prosperini P, Stratta P (2000). Cognitive function in euthymic bipolar patients, stabilized schizophrenic patients, and healthy controls. Journal of Psychiatric Research 34, 333339.
Rubia K, Overmeyer S, Taylor E, Brammer M, Williams SC, Simmons A, Andrew C, Bullmore ET (2000). Functional frontalisation with age: mapping neurodevelopmental trajectories with fMRI. Neuroscience and Biobehavioral Reviews 24, 1319.
Rubinsztein JS, Michael A, Paykel ES, Sahakian BJ (2000). Cognitive impairment in remission in bipolar affective disorder. Psychological Medicine 30, 10251036.
Sanchez-Morla EM, Barabash A, Martinez-Vizcaino V, Tabares-Seisdedos R, Balanza-Martinez V, Cabranes-Diaz JA, Baca-Baldomero E, Gomez JL (2009). Comparative study of neurocognitive function in euthymic bipolar patients and stabilized schizophrenic patients. Psychiatry Research 169, 220228.
Saykin AJ, Gur RC, Gur RE, Mozley PD, Mozley LH, Resnick SM, Kester DB, Stafiniak P (1991). Neuropsychological function in schizophrenia. Selective impairment in memory and learning. Archives of General Psychiatry 48, 618624.
Schaie KW (1980). Intelligence change in adulthood [in German]. Zeitschrift für Gerontologie 15, 373384.
Schaie KW (1994). The course of adult intellectual development. The American Psychologist 49, 304313.
Schretlen DJ, Cascella NG, Meyer SM, Kingery LR, Testa SM, Munro CA, Pulver AE, Rivkin P, Rao VA, Diaz-Asper CM, Dickerson FB, Yolken RH, Pearlson GD (2007). Neuropsychological functioning in bipolar disorder and schizophrenia. Biological Psychiatry 62, 179186.
Schultze-Lutter F, Ruhrmann S, Picker H, von Reventlow HG, Daumann B, Brockhaus-Dumke A, Klosterkkotter J, Pukrop R (2007). Relationship between subjective and objective cognitive function in the early and late prodrome. British Journal of Psychiatry. Supplement 51, s43s51.
Seidman LJ, Buka SL, Goldstein JM, Tsuang MT (2006 a). Intellectual decline in schizophrenia: evidence from a prospective birth cohort 28 year follow-up study. Journal of Clinical and Experimental Neuropsychology 28, 225242.
Seidman LJ, Giuliano AJ, Smith CW, Stone WS, Glatt SJ, Meyer E, Faraone SV, Tsuang MT, Cornblatt B (2006 b). Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and Hillside Adolescent High Risk Studies. Schizophrenia Bulletin 32, 507524.
Seidman LJ, Kremen WS, Koren D, Faraone SV, Goldstein JM, Tsuang MT (2002). A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophrenia Research 53, 3144.
Seidman LJ, Lanca M, Kremen WS, Faraone SV, Tsuang MT (2003). Organizational and visual memory deficits in schizophrenia and bipolar psychoses using the Rey-Osterrieth complex figure: effects of duration of illness. Journal of Clinical and Experimental Neuropsychology 25, 949964.
Selva G, Salazar J, Balanza-Martinez V, Martinez-Aran A, Rubio C, Daban C, Sanchez-Moreno J, Vieta E, Tabares-Seisdedos R (2007). Bipolar I patients with and without a history of psychotic symptoms: do they differ in their cognitive functioning? Journal of Psychiatric Research 41, 265272.
Simon AE, Cattapan-Ludewig K, Zmilacher S, Arbach D, Gruber K, Dvorsky DN, Roth B, Isler E, Zimmer A, Umbricht D (2007). Cognitive functioning in the schizophrenia prodrome. Schizophrenia Bulletin 33, 761771.
Simonsen C, Sundet K, Vaskinn A, Birkenaes AB, Engh JA, Faerden A, Jonsdottir H, Ringen PA, Opjordsmoen S, Melle I, Friis S, Andreassen OA (2009). Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophrenia Bulletin. Published online: 14 May 2009, doi:10.1093/schbul/sbp034.
Smith MJ, Barch DM, Csernansky JG (2009). Bridging the gap between schizophrenia and psychotic mood disorders: relating neurocognitive deficits to psychopathology. Schizophrenia Research 107, 6975.
Sowell ER, Thompson PM, Tessner KD, Toga AW (2001). Mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: inverse relationships during postadolescent brain maturation. Journal of Neuroscience 21, 88198829.
Stip E, Dufresne J, Lussier I, Yatham L (2000). A double-blind, placebo-controlled study of the effects of lithium on cognition in healthy subjects: mild and selective effects on learning. Journal of Affective Disorders 60, 147157.
Stip E, Sepehry AA, Prouteau A, Briand C, Nicole L, Lalonde P, Lesage A (2005). Cognitive discernible factors between schizophrenia and schizoaffective disorder. Brain and Cognition 59, 292295.
Sweeney JA, Kmiec JA, Kupfer DJ (2000). Neuropsychologic impairments in bipolar and unipolar mood disorders on the CANTAB neurocognitive battery. Biological Psychiatry 48, 674684.
Tabares-Seisdedos R, Balanza-Martinez V, Salazar-Fraile J, Selva-Vera G, Leal-Cercos C, Gomez-Beneyto M (2003). Specific executive/attentional deficits in patients with schizophrenia or bipolar disorder who have a positive family history of psychosis. Journal of Psychiatric Research 37, 479486.
Tam WC, Liu Z (2004). Comparison of neurocognition between drug-free patients with schizophrenia and bipolar disorder. Journal of Nervous and Mental Disease 192, 464470.
Tiihonen J, Haukka J, Henriksson M, Cannon M, Kieseppa T, Laaksonen I, Sinivuo J, Lonnqvist J (2005). Premorbid intellectual functioning in bipolar disorder and schizophrenia: results from a cohort study of male conscripts. American Journal of Psychiatry 162, 19041910.
Torrey EF (1999). Epidemiological comparison of schizophrenia and bipolar disorder. Schizophrenia Research 39, 101106; discussion 159–160.
Toulopoulou T, Quraishi S, McDonald C, Murray RM (2006). The Maudsley Family Study: premorbid and current general intellectual function levels in familial bipolar I disorder and schizophrenia. Journal of Clinical and Experimental Neuropsychology 28, 243259.
Tsuang MT, Winokur G, Crowe RR (1980). Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions. British Journal of Psychiatry 137, 497504.
Uzelac S, Jaeger J, Berns S, Gonzales C (2006). Premorbid adjustment in bipolar disorder: comparison with schizophrenia. Journal of Nervous and Mental Disease 194, 654658.
Valles V, Van Os J, Guillamat R, Gutierrez B, Campillo M, Gento P, Fananas L (2000). Increased morbid risk for schizophrenia in families of in-patients with bipolar illness. Schizophrenia Research 42, 8390.
van Amelsvoort T, Henry J, Morris R, Owen M, Linszen D, Murphy K, Murphy D (2004). Cognitive deficits associated with schizophrenia in velo-cardio-facial syndrome. Schizophrenia Research 70, 223232.
Voglmaier MM, Seidman LJ, Salisbury D, McCarley RW (1997). Neuropsychological dysfunction in schizotypal personality disorder: a profile analysis. Biological Psychiatry 41, 530540.
Wang X, Yao S, Kirkpatrick B, Shi C, Yi J (2008). Psychopathology and neuropsychological impairments in deficit and nondeficit schizophrenia of Chinese origin. Psychiatry Research 158, 195205.
Weickert TW, Goldberg TE, Gold JM, Bigelow LB, Egan MF, Weinberger DR (2000). Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect. Archives of General Psychiatry 57, 907913.
Weinberger DR (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 44, 660669.
Wohlberg GW, Kornetsky C (1973). Sustained attention in remitted schizophrenics. Archives of General Psychiatry 28, 533537.
Woodberry KA, Giuliano AJ, Seidman LJ (2008). Premorbid IQ in schizophrenia: a meta-analytic review. American Journal of Psychiatry 165, 579587.
Woodward ND, Purdon SE, Meltzer HY, Zald DH (2005). A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia. International Journal of Neuropsychopharmacology 8, 457472.
Zalewski C, Johnson-Selfridge MT, Ohriner S, Zarrella K, Seltzer JC (1998). A review of neuropsychological differences between paranoid and nonparanoid schizophrenia patients. Schizophrenia Bulletin 24, 127145.
Zubieta JK, Huguelet P, O'Neil RL, Giordani BJ (2001). Cognitive function in euthymic bipolar I disorder. Psychiatry Research 102, 9–20.
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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
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