Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 56
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Lara, Elvira Haro, Josep Maria Tang, Ming-Xin Manly, Jennifer and Stern, Yaakov 2016. Exploring the excess mortality due to depressive symptoms in a community-based sample: The role of Alzheimer's Disease. Journal of Affective Disorders, Vol. 202, p. 163.


    Adams, C. Donnelly, C. and Macdonald, A. 2015. Adverse selection in a start-up long-term care insurance market. British Actuarial Journal, Vol. 20, Issue. 02, p. 298.


    Moon, Yeonsil Kim, Heejin Ok Kim, Jin and Han, Seol-Heui 2014. Vascular factors are associated with the severity of the neuropsychiatric symptoms in Alzheimer's disease. International Journal of Neuroscience, Vol. 124, Issue. 7, p. 512.


    Singh, Inderpal Varanasi, Amrita and Williamson, Kathryn 2014. Assessment and management of dementia in the general hospital setting. Reviews in Clinical Gerontology, Vol. 24, Issue. 03, p. 205.


    Hoe, Juanita Cooper, Claudia and Livingston, Gill 2013. An overview of the LASER-AD study: A longitudinal epidemiological study of people with Alzheimer's disease. International Review of Psychiatry, Vol. 25, Issue. 6, p. 659.


    Mölsä, P. K. Marttila, R. J. and Rinne, U. K. 2009. Long-term survival and predictors of mortality in Alzheimer's disease and multi-infarct dementia. Acta Neurologica Scandinavica, Vol. 91, Issue. 3, p. 159.


    Paradise, Matt Cooper, Claudia and Livingston, Gill 2009. Systematic review of the effect of education on survival in Alzheimer's disease. International Psychogeriatrics, Vol. 21, Issue. 01, p. 25.


    Paradise, Matt Walker, Zuzana Cooper, Claudia Blizard, Robert Regan, Ciaran Katona, Cornelius and Livingston, Gill 2009. Prediction of survival in Alzheimer's disease-The LASER-AD longitudinal study. International Journal of Geriatric Psychiatry, Vol. 24, Issue. 7, p. 739.


    Ballard, Clive Day, Sarah Sharp, Sally Wing, Gayle and Sorensen, Susanne 2008. Neuropsychiatric symptoms in dementia: Importance and treatment considerations. International Review of Psychiatry, Vol. 20, Issue. 4, p. 396.


    López, Oscar L. and DeKosky, Steven T. 2008. Dementias.


    Okonkwo, Ozioma C. Wadley, Virginia G. Griffith, H Randall Belue, Katherine Lanza, Sara Zamrini, Edward Y. Harrell, Lindy E. Brockington, John C. Clark, David Raman, Rema and Marson, Daniel C. 2008. Awareness of Deficits in Financial Abilities in Patients With Mild Cognitive Impairment: Going Beyond Self-Informant Discrepancy. The American Journal of Geriatric Psychiatry, Vol. 16, Issue. 8, p. 650.


    Cacciatore, Francesco Mazzella, Francesca Abete, Pasquale Viati, Luisa Galizia, Gianluigi D'Ambrosio, Daniele Gargiulo, Gaetano Russo, Salvatore Visconti, Claudia Morte, David Della Ferrara, Nicola and Rengo, Franco 2007. Mortality and Heart Rate in the Elderly: Role of Cognitive Impairment. Experimental Aging Research, Vol. 33, Issue. 2, p. 127.


    Crutch, Sebastian J. Rossor, Martin N. and Warrington, Elizabeth K. 2007. A novel technique for the quantitative assessment of apraxic deficits: Application to individuals with mild cognitive impairment. Journal of Neuropsychology, Vol. 1, Issue. 2, p. 237.


    Crutch, Sebastian J. Rossor, Martin N. and Warrington, Elizabeth K. 2007. The Quantitative Assessment of Apraxic Deficits in Alzheimer's Disease. Cortex, Vol. 43, Issue. 7, p. 976.


    Dekosky, Steven T. and Lopez, Oscar L. 2007. The Dementias 2.


    Cosentino, Stephanie Scarmeas, Nikolaos Albert, Steven M. and Stern, Yaakov 2006. Verbal Fluency Predicts Mortality in Alzheimer Disease. Cognitive and Behavioral Neurology, Vol. 19, Issue. 3, p. 123.


    Thomas, A. J. Hendriksen, M. Piggott, M. Ferrier, I. N. Perry, E. Ince, P. and O'Brien, J. T. 2006. A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression. Neuropathology and Applied Neurobiology, Vol. 32, Issue. 3, p. 296.


    Wilson, Robert S. Li, Yan Aggarwal, Neelum T. McCann, Judy J. Gilley, David W. Bienias, Julia L. Barnes, Lisa L. and Evans, Denis A. 2006. Cognitive decline and survival in Alzheimer's disease. International Journal of Geriatric Psychiatry, Vol. 21, Issue. 4, p. 356.


    Dorenlot, Pascale Harboun, Marc Bige, Vincent Henrard, Jean-Claude and Ankri, Jo�l 2005. Major depression as a risk factor for early institutionalization of dementia patients living in the community. International Journal of Geriatric Psychiatry, Vol. 20, Issue. 5, p. 471.


    Fornazzari, L. R. 2005. Preserved painting creativity in an artist with Alzheimer's disease. European Journal of Neurology, Vol. 12, Issue. 6, p. 419.


    ×

Factors affecting survival in Alzheimer's disease

  • Alistair Burns (a1), Glyn Lewis (a1), Robin Jacoby (a1) and Raymond Levy (a1)
  • DOI: http://dx.doi.org/10.1017/S0033291700020468
  • Published online: 01 July 2009
Abstract
SYNOPSIS

Factors affecting survival of 178 patients diagnosed using NINCDS/ADRDA criteria for Alzheimer's disease were studied. All patients were drawn from the Camberwell Health Authority Area and so were a representative sample of subjects from a clinical old age psychiatry service. The mortality rate of the sample was 3·5 times that expected after adjustment for age. Younger subjects had a higher standardized mortality ratio than older subjects. The cumulative three-year mortality of the sample was 47%. Factors shown to be associated with a reduced survival included: increasing age, longer duration of illness, male sex, presence of physical illness, poor cognitive function, observed depression and absence of misidentification syndromes. Apraxia was a stronger predictor of early death than aphasia or dysmnesia.

Copyright
Corresponding author
1Address for correspondence: Dr Alistair Burns, Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF.
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

L. Barclay , A. Zemcov , J. Blass & F. McDowell (1985). Factors associated with duration of survival in Alzheimer's disease. Biological Psychiatry 20, 8693.

L. Berg , W. Danziger , M. Storandt , L. Coben , M. Gado , C. Hughes , J. Knesevich & J. Botwinick (1984). Predictive features in mild senile dementia of the Alzheimer type. Neurology 34, 563569.

A. Burns , P. Cuthbert , R. Levy , R. Jacoby & P. Lantos (1990 a). Accuracy of clinical diagnosis in Alzheimer's disease. British Medical Journal 301, 1026.

O. Camargo & G. Preston (1945). What happen to patients who are hospitalised for the first time when over 65 years of age. American Journal of Psychiatry 102, 168173.

A. Christie (1982). Changing patterns in mental illness in the elderly. British Journal of Psychiatry 140, 154159.

A. Christie & E. Wood (1988). Age, clinical features and prognosis in SDAT. International Journal of Geriatric Psychiatry 3, 6368.

J. Colgan (1985). Regional density and survival in senile dementia. British Journal of Psychiatry 147, 6366.

W. Drevets & E. Rubin (1989). Psychotic symptoms in the longitudinal course of senile dementia of the Alzheimer type. Biological Psychiatry 25, 3948.

K. Faber-Langendoen , J. Morris , J. Knesevich , E. Labarge , J. Miller & L. Berg (1988). Aphasia in senile dementia of the Alzheimer type. Annals of Neurology 23, 365370.

M. Folstein , S. Folstein & P. McHugh (1975). Mini-Mental State Examination. Journal of Psychiatric Research 12, 189198.

A. Goldfarb (1969). Predicting mortality in the institutionalized aged. Archives of General Psychiatry 21, 172176.

A. Heyman , W. Wilkinson , B. Hurwitz , M. Helms , C. Haynes , C. Utley & L. Gwyther (1987). Early onset Alzheimer's disease: clinical predictors of institutionalisation and death. Neurology 37, 980984.

A. Kaszniak , J. Fox , D. Gandell , D. Garron , M. Huckman & R. Ramsey (1978). Predictors of mortality in presenile dementia. Annals of Neurology 3, 246252.

D. Kay (1962). Outcome and cause of death in mental disorders of old age: a longer term follow-up of functional and organic psychoses. Acta Psychiatrica Scandinavica 38, 249276.

D. Kay & K. Bergmann (1966). Physical disability and mental health in old age. Journal of Psychosomatic Research 10, 312.

J. Knesevich , F. Toro , J. Morris & E. Labarge (1985). Aphasia, family history and the longitudinal course of senile dementia of the Alzheimer type. Psychiatry Research 14, 255263.

C. McDonald (1969). Clinical heterogeneity in senile dementia. British Journal of Psychiatry 115, 267271.

G. McKhann , D. Drachman , M. Folstein , R. Katzmas , D. Price & E. Stadlar (1984). Clinical diagnosis of Alzheimer's disease: report on the NINCDS/ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34, 939944.

E. Martin , R. Wilson , R. Penn , J. Fox , R. Clasen & S. Savoy (1987). Cortical biopsy results in Alzheimer's disease: correlation of cognitive deficits. Neurology 37, 12011204.

M. Naguib & R. Levy (1982 a). Prediction of outcome in senile dementia – a computed tomography study. British Journal of Psychiatry 140, 263267.

M. Naguib & R. Levy (1982 b). CT scanning in senile dementia. A follow-up of survivors. British Journal of Psychiatry 141, 618620.

M. Roth , E. Tym , C. Mountjoy , F. Huppert , H. Hendrie , S. Verma & R. Goddard (1986). CAMDEX. British Journal of Psychiatry 149, 698709.

B. Seltzer & I. Sherwin (1983). The comparison of clinical features in early and late onset primary degenerative dementia. Archives of Neurology 40, 143146.

K. Shah , G. Banks & H. Merskey (1969). Survival in arteriosclerotic and senile dementia. British Journal of Psychiatry 115, 12831286.

Y. Stern , R. Mayeux , M. Sano , W. Hauser & T. Bush (1987). Predictors of disease course in patients with probable Alzheimer's disease. Neurology 37, 16491653.

M. Tierney , R. Fischer , A. Lewis , M. Zorzitto , G. Snow , D. Reid & P. Nieuwstaten (1988). The NINCDS/ADRDA workgroup criteria for the clinical diagnosis of probable Alzheimer's disease. Neurology 38, 359364.

G. Zubenko & J. Moossy (1988). Major depression in primary dementia – clinical and neuropathologic correlates. Archives of Neurology 45, 11821186.

R. Zweig , C. Ross , J. Hedren , C. Steele , J. Cardillo , P. Whitehouse , M. Folstein & D. Price (1988). The neuropathology of aminergic nuclei in Alzheimer's disease. Annals of Neurology 24, 233242.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×