Hahn, Britta Harvey, Alexander N. Gold, James M. Ross, Thomas J. and Stein, Elliot A. 2017. Load-dependent hyperdeactivation of the default mode network in people with schizophrenia. Schizophrenia Research,
Baenninger, Anja Diaz Hernandez, Laura Rieger, Kathryn Ford, Judith M. Kottlow, Mara and Koenig, Thomas 2016. Inefficient Preparatory fMRI-BOLD Network Activations Predict Working Memory Dysfunctions in Patients with Schizophrenia. Frontiers in Psychiatry, Vol. 7,
Biskup, C. S. Helmbold, K. Baurmann, D. Klasen, M. Gaber, T. J. Bubenzer-Busch, S. Königschulte, W. Fink, G. R. and Zepf, F. D. 2016. Resting state default mode network connectivity in children and adolescents with ADHD after acute tryptophan depletion. Acta Psychiatrica Scandinavica, Vol. 134, Issue. 2, p. 161.
Haatveit, Beathe Jensen, Jimmy Alnæs, Dag Kaufmann, Tobias Brandt, Christine L. Thoresen, Christian Andreassen, Ole A. Melle, Ingrid Ueland, Torill and Westlye, Lars T. 2016. Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders. NeuroImage: Clinical, Vol. 12, p. 389.
Hahn, Britta Harvey, Alexander N. Gold, James M. Fischer, Bernard A. Keller, William R. Ross, Thomas J. and Stein, Elliot A. 2016. Hyperdeactivation of the Default Mode Network in People With Schizophrenia When Focusing Attention in Space. Schizophrenia Bulletin, Vol. 42, Issue. 5, p. 1158.
Hanlon, Faith M. Shaff, Nicholas A. Dodd, Andrew B. Ling, Josef M. Bustillo, Juan R. Abbott, Christopher C. Stromberg, Shannon F. Abrams, Swala Lin, Denise S. and Mayer, Andrew R. 2016. Hemodynamic response function abnormalities in schizophrenia during a multisensory detection task. Human Brain Mapping, Vol. 37, Issue. 2, p. 745.
Hu, Mao-Lin Zong, Xiao-Fen Mann, J. John Zheng, Jun-Jie Liao, Yan-Hui Li, Zong-Chang He, Ying Chen, Xiao-Gang and Tang, Jin-Song 2016. A Review of the Functional and Anatomical Default Mode Network in Schizophrenia. Neuroscience Bulletin,
Lee, P H Baker, J T Holmes, A J Jahanshad, N Ge, T Jung, J-Y Cruz, Y Manoach, D S Hibar, D P Faskowitz, J McMahon, K L de Zubicaray, G I Martin, N H Wright, M J Öngür, D Buckner, R Roffman, J Thompson, P M and Smoller, J W 2016. Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia. Molecular Psychiatry, Vol. 21, Issue. 12, p. 1680.
Madre, M. Canales-Rodríguez, E. J. Ortiz-Gil, J. Murru, A. Torrent, C. Bramon, E. Perez, V. Orth, M. Brambilla, P. Vieta, E. and Amann, B. L. 2016. Neuropsychological and neuroimaging underpinnings of schizoaffective disorder: a systematic review. Acta Psychiatrica Scandinavica, Vol. 134, Issue. 1, p. 16.
Metcalfe, A W S MacIntosh, B J Scavone, A Ou, X Korczak, D and Goldstein, B I 2016. Effects of acute aerobic exercise on neural correlates of attention and inhibition in adolescents with bipolar disorder. Translational Psychiatry, Vol. 6, Issue. 5, p. e814.
Molina, Vicente Bachiller, Alejandro Suazo, Vanessa Lubeiro, Alba Poza, Jesús and Hornero, Roberto 2016. Noise power associated with decreased task-induced variability of brain electrical activity in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, Vol. 266, Issue. 1, p. 55.
Moran, Joseph M. 2016. Neuroimaging Personality, Social Cognition, and Character.
Mothersill, Omar Tangney, Noreen Morris, Derek W. McCarthy, Hazel Frodl, Thomas Gill, Michael Corvin, Aiden and Donohoe, Gary 2016. Further evidence of alerted default network connectivity and association with theory of mind ability in schizophrenia. Schizophrenia Research,
Salgado-López, Laura Pomarol-Clotet, Edith Roldán, Alexandra Rodríguez, Rodrigo Molet, Joan Sarró, Salvador Álvarez, Enric and Corripio, Iluminada 2016. Letter to the Editor: Deep brain stimulation for schizophrenia. Journal of Neurosurgery, Vol. 125, Issue. 1, p. 229.
Salgado-Pineda, Pilar Landin-Romero, Ramón Portillo, Francisco Bosque, Clara Pomes, Ausias Spanlang, Bernhard Franquelo, Jose Carlos Teixido, Cristina Sarró, Salvador Salvador, Raymond Slater, Mel Pomarol-Clotet, Edith and McKenna, Peter J. 2016. Examining hippocampal function in schizophrenia using a virtual reality spatial navigation task. Schizophrenia Research, Vol. 172, Issue. 1-3, p. 86.
Sampaio, Adriana Moreira, Pedro Silva Osório, Ana Magalhães, Ricardo Vasconcelos, Cristiana Férnandez, Montse Carracedo, Angel Alegria, Joana Gonçalves, Óscar F. and Soares, José Miguel 2016. Altered functional connectivity of the default mode network in Williams syndrome: a multimodal approach. Developmental Science, Vol. 19, Issue. 4, p. 686.
Sutcliffe, Grant Harneit, Anais Tost, Heike and Meyer-Lindenberg, Andreas 2016. Neuroimaging Intermediate Phenotypes of Executive Control Dysfunction in Schizophrenia. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 1, Issue. 3, p. 218.
Wang, L. Wu, L. Lin, X. Zhang, Y. Zhou, H. Du, X. and Dong, G. 2016. Dysfunctional default mode network and executive control network in people with Internet gaming disorder: Independent component analysis under a probability discounting task. European Psychiatry, Vol. 34, p. 36.
Zhou, Li Pu, Weidan Wang, Jingjuan Liu, Haihong Wu, Guowei Liu, Chang Mwansisya, Tumbwene E. Tao, Haojuan Chen, Xudong Huang, Xiaojun Lv, Dongsheng Xue, Zhimin Shan, Baoci and Liu, Zhening 2016. Inefficient DMN Suppression in Schizophrenia Patients with Impaired Cognitive Function but not Patients with Preserved Cognitive Function. Scientific Reports, Vol. 6, p. 21657.
Functional imaging studies using working memory tasks have documented both prefrontal cortex (PFC) hypo- and hyperactivation in schizophrenia. However, these studies have often failed to consider the potential role of task-related deactivation.
Thirty-two patients with chronic schizophrenia and 32 age- and sex-matched normal controls underwent functional magnetic resonance imaging (fMRI) scanning while performing baseline, 1-back and 2-back versions of the n-back task. Linear models were used to obtain maps of activations and deactivations in the groups.
The controls showed activation in the expected frontal regions. There were also clusters of deactivation, particularly in the anterior cingulate/ventromedial PFC and the posterior cingulate cortex/precuneus. Compared to the controls, the schizophrenic patients showed reduced activation in the right dorsolateral prefrontal cortex (DLPFC) and other frontal areas. There was also an area in the anterior cingulate/ventromedial PFC where the patients showed apparently greater activation than the controls. This represented a failure of deactivation in the schizophrenic patients. Failure to activate was a function of the patients' impaired performance on the n-back task, whereas the failure to deactivate was less performance dependent.
Patients with schizophrenia show both failure to activate and failure to deactivate during performance of a working memory task. The area of failure of deactivation is in the anterior prefrontal/anterior cingulate cortex and corresponds to one of the two midline components of the ‘default mode network’ implicated in functions related to maintaining one's sense of self.
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