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Heterogeneity in cognitive functioning of schizophrenic patients evaluated by a lexical decision task

  • C. PASSERIEUX (a1), J. SEGUI (a1), C. BESCHE (a1), J. F. CHEVALIER (a1), D. WIDLÖCHER (a1) and M. C. HARDY-BAYLÉ (a1)...
    • Published online: 01 November 1997

Background. The disorganization pattern in schizophrenia, which involves formal thought disorders, is thought to be correlated with a deficit in integrative processes of contextual information. We tested the hypothesis that thought disordered schizophrenics, unlike non-thought disordered schizophrenics, would present a deficit in the processing of the context during a task which involves these integrative processes.

Methods. A group of 22 schizophrenic patients diagnosed in accordance with DSM-III-R criteria and a group of 11 control subjects were compared using a semantic priming version of the lexical decision task. The experimental design used low-level structuration of verbal material to reveal the difficulty that schizophrenic patients encounter in using semantic regularities.

Results. A significant difference in priming effect was found between the three groups. Control subjects and non-thought disordered schizophrenics exhibit a priming effect for related word pairs when compared with unrelated pairs (respectively F(1,10)=17·7; P<0·002 and F(1,10)=14·5; P>0·003) but thought disordered schizophrenics did not (F(1,10)<1; NS).

Conclusions. This finding provides evidence for the cognitive heterogeneity of schizophrenic subjects. This absence of priming effect in thought-disordered schizophrenic subjects supports the hypothesis that these patients present a deficit in the post-lexical controlled information processing that permits the integration of semantic information.

Corresponding author
Address for correspondence: Dr Christine Passerieux, Service de psychiatrie, Hôpital Richaud, 1, rue Richaud, 78011 Versailles Cédex, France.
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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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