Skip to main content
×
Home
    • Aa
    • Aa

Hippocampal function in schizophrenia and bipolar disorder

  • J. Hall (a1), H. C. Whalley (a1), K. Marwick (a1), J. McKirdy (a1), J. Sussmann (a1), L. Romaniuk (a1), E. C. Johnstone (a1), H. I. Wan (a2), A. M. McIntosh (a1) and S. M. Lawrie (a1)...
Abstract
Background

The hippocampus plays a central role in memory formation. There is considerable evidence of abnormalities in hippocampal structure and function in schizophrenia, which may differentiate it from bipolar disorder. However, no previous studies have compared hippocampal activation in schizophrenia and bipolar disorder directly.

Method

Fifteen patients with schizophrenia, 14 patients with bipolar disorder and 14 healthy comparison subjects took part in the study. Subjects performed a face–name pair memory task during functional magnetic resonance imaging (fMRI). Differences in blood oxygen level-dependent (BOLD) activity were determined during encoding and retrieval of the face–name pairs.

Results

The patient groups showed significant differences in hippocampal and prefrontal cortex (PFC) activation during face–name pair learning. During encoding, patients with schizophrenia showed decreased anterior hippocampal activation relative to subjects with bipolar disorder, whereas patients with bipolar disorder showed decreased dorsal PFC activation relative to patients with schizophrenia. During retrieval, patients with schizophrenia showed greater activation of the dorsal PFC than patients with bipolar disorder. Patients with schizophrenia also differed from healthy control subjects in the activation of several brain regions, showing impaired superior temporal cortex activation during encoding and greater dorsal PFC activation during retrieval. These effects were evident despite matched task performance.

Conclusions

Patients with schizophrenia showed deficits in hippocampal activation during a memory task relative to patients with bipolar disorder. The disorders were further distinguished by differences in PFC activation. The results demonstrate that these disorders can distinguished at a group level using non-invasive neuroimaging.

Copyright
Corresponding author
*Address for correspondence: Dr J. Hall, Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, EdinburghEH10 5HF, UK. (Email: jhall5@staffmail.ed.ac.uk)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

AM Achim , M Lepage (2003). Is associative recognition more impaired than item recognition memory in schizophrenia? A meta-analysis. Brain and Cognition 53, 121124.

AM Achim , M Lepage (2005). Episodic memory-related activation in schizophrenia: meta-analysis. British Journal of Psychiatry 187, 500509.

HP Blumberg , H-C Leung , P Skudlarski , CM Lacadie , CA Fredericks , BC Harris , DS Charney , JC Gore , JH Krystal , BS Peterson (2003). A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry 60, 601609.

RS Blumenfeld , C Ranganath (2007). Prefrontal cortex and long-term memory encoding: an integrative review of findings from neuropsychology and neuroimaging. Neuroscientist 13, 280291.

HBM Boos , A Aleman , W Cahn , HH Pol , RS Kahn (2007). Brain volumes in relatives of patients with schizophrenia: a meta-analysis. Archives of General Psychiatry 64, 297304.

JH Callicott , VS Mattay , BA Verchinski , S Marenco , MF Egan , DR Weinberger (2003). Complexity of prefrontal cortical dysfunction in schizophrenia: more than up or down. American Journal of Psychiatry 160, 22092215.

J-M Danion , L Rizzo , A Bruant (1999). Functional mechanisms underlying impaired recognition memory and conscious awareness in patients with schizophrenia. Archives of General Psychiatry 56, 639644.

T Deckersbach , DD Dougherty , C Savage , S McMurrich , AJ Fischman , A Nierenberg , G Sachs , SL Rauch (2006). Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorder. Biological Psychiatry 59, 138146.

RJ Dolan , PF Fletcher (1999). Encoding and retrieval in human medial temporal lobes: an empirical investigation using functional magnetic resonance imaging (fMRI). Hippocampus 9, 2534.

M Haldane , S Frangou (2004). New insights help define the pathophysiology of bipolar affective disorder: neuroimaging and neuropathology findings. Progress in Neuro-Psychopharmacology and Biological Psychiatry 28, 943960.

M Hamilton (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 5662.

S Heckers (2001). Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus 11, 520528.

S Heckers , S Rauch , D Goff , C Savage , D Schacter , A Fischman , N Alpert (1998). Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nature Neuroscience 1, 318323.

SR Kay , A Fiszbein , LA Opler (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261276.

NS Lawrence , AM Williams , S Surguladze , V Giampietro , MJ Brammer , C Andrew , S Frangou , C Ecker , ML Phillips (2004). Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biological Psychiatry 55, 578587.

JE Lisman , JT Coyle , RW Green , DC Javitt , FM Benes , S Heckers , AA Grace (2008). Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends in Neurosciences 31, 234242.

JA Maldjian , PJ Laurienti , RA Kraft , JH Burdette (2003). An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage 19, 12331239.

PJ Monks , JM Thompson , ET Bullmore , J Suckling , MJ Brammer , SC Williams , A Simmons , N Giles , AJ Lloyd , CL Harrison , M Seal , RM Murray , IN Ferrier , AH Young , VA Curtis (2004). A functional MRI study of working memory task in euthymic bipolar disorder: evidence for task-specific dysfunction. Bipolar Disorders 6, 550564.

D Ongur , TJ Cullen , DH Wolf , M Rohan , P Barreira , M Zalesak , S Heckers (2006). The neural basis of relational memory deficits in schizophrenia. Archives of General Psychiatry 63, 356365.

R Sperling , E Chua , A Cocchiarella , E Rand-Giovannetti , R Poldrack , DL Schacter , M Albert (2003). Putting names to faces: successful encoding of associative memories activates the anterior hippocampal formation. NeuroImage 20, 14001410.

SM Strakowski , MP DelBello , CM Adler (2004). The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Molecular Psychiatry 10, 105116.

T Toulopoulou , S Rabe-Hesketh , H King , RM Murray , RG Morris (2003). Episodic memory in schizophrenic patients and their relatives. Schizophrenia Research 63, 261271.

N Tzourio-Mazoyer , B Landeau , D Papathanassiou , F Crivello , O Etard , N Delcroix , B Mazoyer , M Joliot (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage 15, 273289.

F Vargha-Khadem , DG Gadian , KE Watkins , A Connelly , W Van Paesschen , M Mishkin (1997). Differential effects of early hippocampal pathology on episodic and semantic memory. Science 277, 376380.

SW Woods (2003). Chlorpromazine equivalent doses of the newer atypical antipsychotics. Journal of Clinical Psychiatry 64, 663667.

IC Wright , S Rabe-Hesketh , PWR Woodruff , AS David , RM Murray , ET Bullmore (2000). Meta-analysis of regional brain volumes in schizophrenia. American Journal of Psychiatry 157, 1625.

MM Zeineh , SA Engel , PM Thompson , SY Bookheimer (2003). Dynamics of the hippocampus during encoding and retrieval of face–name pairs. Science 299, 577580.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
WORD
Supplementary Materials

Hall supplementary material
Tables.doc

 Word (159 KB)
159 KB

Metrics

Full text views

Total number of HTML views: 7
Total number of PDF views: 20 *
Loading metrics...

Abstract views

Total abstract views: 150 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 23rd May 2017. This data will be updated every 24 hours.