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Hypothyroidism in patients treated with lithium: a review and two case reports

Published online by Cambridge University Press:  09 July 2009

M. J. Crowe ,
G. G. Lloyd ,
S. Bloch  and
R. M. Rosser
M. J. Crowe
Affiliation:
From the Bethlem Royal and Maudsley Hospitals, Denmark Hill, London
G. G. Lloyd
Affiliation:
From the Bethlem Royal and Maudsley Hospitals, Denmark Hill, London
S. Bloch
Affiliation:
From the Bethlem Royal and Maudsley Hospitals, Denmark Hill, London
R. M. Rosser
Affiliation:
From the Bethlem Royal and Maudsley Hospitals, Denmark Hill, London
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Synopsis

Two different types of hypothyroidism can occur during lithium administration, one with evidence of underlying thyroiditis, the other without. Two cases are reported, one of type 1, the other of type 2, and 17 other cases of lithium-induced hypothyroidism in the literature are reviewed. The literature on the occurrence of goitre during lithium treatment, and that on the alteration of thyroid function tests are also reviewed. Possible mechanisms for the disturbance of thyroid function are discussed and recommendations for managing this complication of lithium therapy are made.

Type
Research Article
Information
Psychological Medicine , Volume 3 , Issue 3 , August 1973 , pp. 337 - 342
Copyright
Copyright © Cambridge University Press 1973

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References

REFERENCES

Bennie, E. H., and Lazarus, J. H. (1972). Lithium-induced thyroid dysfunction. Lancet, 2, 44–45.CrossRefGoogle ScholarPubMed
Berens, S. C., Bernstein, R. S., Robbins, J., and Wolff, J. (1970). Antithyroid effects of lithium. Journal of Clinical Investigation, 49, 1357–1367.CrossRefGoogle ScholarPubMed
Birch, C. R., Jolley, D. J., Hay, G. G., and Dymock, I. W. (1972). Lithium therapy and hypothyroidism. British Medical Journal, 4, 233.CrossRefGoogle ScholarPubMed
Candy, J. (1972). Severe hypothyroidism an early complication of lithium therapy. British Medical Journal, 3, 277.CrossRefGoogle ScholarPubMed
Cooper, T. B., and Simpson, G. M. (1969). Preliminary report of a longitudinal study on the effects of lithium on iodine metabolism. Current Therapeutic Research, 11, 603 608.Google ScholarPubMed
Fieve, R. R., and Platman, S. R. (1968). Lithium and thyroid function in manic-depressive psychosis. American Journal of Psychiatry, 125, 527–530.CrossRefGoogle ScholarPubMed
Fieve, R. R., and Platman, S. R. (1969). Follow-up studies of lithium and thyroid function in manic-depressive illness. American Journal of Psychiatry, 125, 1443–1445.CrossRefGoogle ScholarPubMed
Gonzales, R., and Lauter, H. (1968). Zur Therapie manischdepressiver Psychosen mit Lithiumsalzen. Der Nervenarzt, 39, 11–16.Google Scholar
Halberg, P., Dige-Petersen, H., Werdelin, O., Simonsen, J., and Rafaelsen, O. J. (1968). Thyreoideapåvirkning under lithiumbehandling. Ugeskrift fur Laeger, 130, 1521–1523.Google Scholar
Hanna, S. M., Jenner, F. A., Pearson, I. B., Sampson, G. A., and Thompson, E. A. (1972). The therapeutic effect of lithium carbonate on a patient with a forty-eight hour periodic psychosis. British Journal of Psychiatry, 121, 271–280.CrossRefGoogle ScholarPubMed
Hullin, R. P., McDonald, R., and Allsopp, M. N. E. (1972). Prophylactic lithium in recurrent affective disorders. Lancet, 1, 1044–1046.CrossRefGoogle ScholarPubMed
Lazarus, J. H., and Bennie, E. H. (1972). Effect of lithium on thyroid function in man. Acta Endocrinologica (Copenhagen), 70, 266–272.Google ScholarPubMed
Maletzky, B., and Blachly, P. H. (1971). The Use of Lithium in Psychiatry. Butterworths: London.CrossRefGoogle ScholarPubMed
Myers, E. D. (1972). Prophylactic lithium in recurrent affective disorders. Lancet, 1, 1287.CrossRefGoogle ScholarPubMed
Rogers, M. P., and Whybrow, P. C. (1971). Clinical hypothyroidism occurring during lithium treatment. Two case histories and a review of thyroid function in 19 patients. American Journal of Psychiatry, 128, 158–163.CrossRefGoogle Scholar
Schou, M., Amdisen, A., Jensen, S. E., and Olsen, T. (1968). Occurrence of goitre during lithium treatment. British Medical Journal, 3, 710–713.CrossRefGoogle ScholarPubMed
Sedvall, G., Jönsson, B., Pettersson, U. and Levin, K. (1968). Effects of lithium salts on plasma protein bound iodine and uptake of 1131 in thyroid gland of man and rat. Life Sciences, Part 1, 7, 1257–1264.CrossRefGoogle Scholar
Sedvall, G., Jönsson, B., and Pettersson, U. (1969). Evidence of an altered thyroid function in man during treatment with lithium carbonate. Acta Psychiatrica Scandinavica, Suppl. 207, 59–67.CrossRefGoogle Scholar
Shopsin, B. (1970). Effects of lithium on thyroid function. (A review.) Diseases of the Nervous System, 31, 237–244.Google ScholarPubMed
Shopsin, B., Blum, M., and Gershon, S. (1969). Lithium-induced thyroid disturbance: case report and review. Comparative Psychiatry, 10, 215–223.CrossRefGoogle ScholarPubMed
Vestergaard, P. A., and Poulsen, J. C. (1972): Myxoedema—possible side-effect of lithium? Lancet, 2, 427–428.CrossRefGoogle ScholarPubMed
Whybrow, P. C., Coppen, A., Prange, A. J., Noguera, R., and Bailey, J. E. (1972). Thyroid function and the response to liothyronine in depression. Archives of General Psychiatry, 26, 242–245.CrossRefGoogle ScholarPubMed
Wiggers, S. (1968). Lithiumspåvirkning af glandula thyreoidea. Ugeskrift for Laeger, 130, 1523–1525.Google Scholar
Williams, J. A., Berens, S. C., and Wolff, J. (1971). Thyroid secretion in vitro: inhibition of TSH and dibutyryl cyclic-AMP-stimulated 131I release by Li +. Endocrinology, 88, 1385–1388.CrossRefGoogle ScholarPubMed