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Impaired awareness of motor intention in functional neurological disorder: implications for voluntary and functional movement

  • K. Baek (a1), N. Doñamayor (a1), L. S. Morris (a2), D. Strelchuk (a1), S. Mitchell (a1), Y. Mikheenko (a1), S. Y. Yeoh (a3), W. Phillips (a4), M. Zandi (a4) (a5) (a6), A. Jenaway (a7), C. Walsh (a1) (a4) and V. Voon (a1) (a2) (a7) (a8)...
Abstract
Background

Functional neurological disorders (FNDs), also known as conversion disorder, are unexplained neurological symptoms unrelated to a neurological cause. The disorder is common, yet poorly understood. The symptoms are experienced as involuntary but have similarities to voluntary processes. Here we studied intention awareness in FND.

Method

A total of 26 FND patients and 25 healthy volunteers participated in this functional magnetic resonance study using Libet's clock.

Results

FND is characterized by delayed awareness of the intention to move relative to the movement itself. The reporting of intention was more precise, suggesting that these findings are reliable and unrelated to non-specific attentional deficits. That these findings were more prominent with aberrant positive functional movement symptoms rather than negative symptoms may be relevant to impairments in timing for an inhibitory veto process. Attention towards intention relative to movement was associated with lower right inferior parietal cortex activity in FND, a region early in the processing of intention. During rest, aberrant functional connectivity was observed with the right inferior parietal cortex and other motor intention regions.

Conclusions

The results converge with observations of low inferior parietal activity comparing involuntary with voluntary movement in FND, emphasizing core deficiencies in intention. Heightened precision of this impaired intention is consistent with Bayesian theories of impaired top-down priors that might influence the sense of involuntariness. A primary impairment in voluntary motor intention at an early processing stage might explain clinical observations of slowed effortful voluntary movement, heightened self-directed attention and underlie functional movements. These findings further suggest novel therapeutic targets.

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Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
*Address for correspondence: V. Voon, M.D., Ph.D., Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Level E4, Box 189, Cambridge CB2 0QQ, UK. (Email: vv247@cam.ac.uk)
Footnotes
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These authors contributed equally to the paper.

Footnotes
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