Feiss, Anna Johnson, Sheri L. Peckham, Andrew and Blair, James 2017. Valence specific response reversal deficits and risk for mania. Motivation and Emotion, Vol. 41, Issue. 5, p. 661.
Vilgis, Veronika Vance, Alasdair Cunnington, Ross and Silk, Timothy J. 2017. White matter microstructure in boys with persistent depressive disorder. Journal of Affective Disorders, Vol. 221, p. 11.
Evans, Spencer C. Burke, Jeffrey D. Roberts, Michael C. Fite, Paula J. Lochman, John E. de la Peña, Francisco R. and Reed, Geoffrey M. 2017. Irritability in child and adolescent psychopathology: An integrative review for ICD-11. Clinical Psychology Review, Vol. 53, p. 29.
Amodeo, Dionisio A. Grospe, Gena Zang, Hui Dwivedi, Yogesh and Ragozzino, Michael E. 2017. Cognitive flexibility impairment and reduced frontal cortex BDNF expression in the ouabain model of mania. Neuroscience, Vol. 345, p. 229.
Milienne-Petiot, Morgane Kesby, James P. Graves, Mary van Enkhuizen, Jordy Semenova, Svetlana Minassian, Arpi Markou, Athina Geyer, Mark A. and Young, Jared W. 2017. The effects of reduced dopamine transporter function and chronic lithium on motivation, probabilistic learning, and neurochemistry in mice: Modeling bipolar mania. Neuropharmacology, Vol. 113, p. 260.
Naiberg, Melanie R. Hatch, Jessica K. Selkirk, Beth Fiksenbaum, Lisa Yang, Victor Black, Sandra Kertes, Peter J. and Goldstein, Benjamin I. 2017. Retinal photography: A window into the cardiovascular-brain link in adolescent bipolar disorder. Journal of Affective Disorders, Vol. 218, p. 227.
Rygula, Rafal and Popik, Piotr 2016. Trait “pessimism” is associated with increased sensitivity to negative feedback in rats. Cognitive, Affective, & Behavioral Neuroscience, Vol. 16, Issue. 3, p. 516.
Dickstein, Daniel P. Axelson, David Weissman, Alexandra B. Yen, Shirley Hunt, Jeffrey I. Goldstein, Benjamin I. Goldstein, Tina R. Liao, Fangzi Gill, Mary Kay Hower, Heather Frazier, Thomas W. Diler, Rasim S. Youngstrom, Eric A. Fristad, Mary A. Arnold, L. Eugene Findling, Robert L. Horwitz, Sarah M. Kowatch, Robert A. Ryan, Neal D. Strober, Michael Birmaher, Boris and Keller, Martin B. 2016. Cognitive flexibility and performance in children and adolescents with threshold and sub-threshold bipolar disorder. European Child & Adolescent Psychiatry, Vol. 25, Issue. 6, p. 625.
Urošević, Snežana Youngstrom, Eric A. Collins, Paul Jensen, Jonathan B. and Luciana, Monica 2016. Associations of age with reward delay discounting and response inhibition in adolescents with bipolar disorders. Journal of Affective Disorders, Vol. 190, p. 649.
Wegbreit, Ezra Cushman, Grace K. Weissman, Alexandra B. Bojanek, Erin Kim, Kerri L. Leibenluft, Ellen and Dickstein, Daniel P. 2016. Reversal-learning deficits in childhood-onset bipolar disorder across the transition from childhood to young adulthood. Journal of Affective Disorders, Vol. 203, p. 46.
Verfaillie, Sander C.J. de Wit, Stella J. Vriend, Chris Remijnse, Peter L. Veltman, Dick J. and van den Heuvel, Odile A. 2016. The course of the neural correlates of reversal learning in obsessive–compulsive disorder and major depression: A naturalistic follow-up fMRI study. Journal of Obsessive-Compulsive and Related Disorders, Vol. 9, p. 51.
Vilgis, Veronika Silk, Timothy J. and Vance, Alasdair 2015. Executive function and attention in children and adolescents with depressive disorders: a systematic review. European Child & Adolescent Psychiatry, Vol. 24, Issue. 4, p. 365.
Uran, Pınar and Kılıç, Birim Günay 2015. Comparison of neuropsychological performances and behavioral patterns of children with attention deficit hyperactivity disorder and severe mood dysregulation. European Child & Adolescent Psychiatry, Vol. 24, Issue. 1, p. 21.
Barlow, Rebecca L Alsiö, Johan Jupp, Bianca Rabinovich, Rebecca Shrestha, Saurav Roberts, Angela C Robbins, Trevor W and Dalley, Jeffrey W 2015. Markers of Serotonergic Function in the Orbitofrontal Cortex and Dorsal Raphé Nucleus Predict Individual Variation in Spatial-Discrimination Serial Reversal Learning. Neuropsychopharmacology, Vol. 40, Issue. 7, p. 1619.
Alm, Kylie H. Rolheiser, Tyler Mohamed, Feroze B. and Olson, Ingrid R. 2015. Fronto-temporal white matter connectivity predicts reversal learning errors. Frontiers in Human Neuroscience, Vol. 9,
Jarcho, Johanna M. Romer, Adrienne L. Shechner, Tomer Galvan, Adriana Guyer, Amanda E. Leibenluft, Ellen Pine, Daniel S. and Nelson, Eric E. 2015. Forgetting the best when predicting the worst: Preliminary observations on neural circuit function in adolescent social anxiety. Developmental Cognitive Neuroscience, Vol. 13, p. 21.
Dickstein, Daniel P. Cushman, Grace K. Kim, Kerri L. Weissman, Alexandra B. and Wegbreit, Ezra 2015. Cognitive remediation: potential novel brain-based treatment for bipolar disorder in children and adolescents. CNS Spectrums, Vol. 20, Issue. 04, p. 382.
Baker, Phillip M. Oh, Sujean E. Kidder, Kevan S. and Mizumori, Sheri J. Y. 2015. Ongoing behavioral state information signaled in the lateral habenula guides choice flexibility in freely moving rats. Frontiers in Behavioral Neuroscience, Vol. 9,
From an affective neuroscience perspective, our understanding of psychiatric illness may be advanced by neuropsychological test paradigms probing emotional processes. Reversal learning is one such process, whereby subjects must first acquire stimulus/reward and stimulus/punishment associations through trial and error and then reverse them. We sought to determine the specificity of previously demonstrated reversal learning impairments in youths with bipolar disorder (BD) by now comparing BD youths to those with severe mood dysregulation (SMD), major depressive disorder (MDD), anxiety (ANX), and healthy controls.
We administered the probabilistic response reversal (PRR) task to 165 pediatric participants aged 7–17 years with BD (n=35), SMD (n=35), ANX (n=42), MDD (n=18) and normal controls (NC; n=35). Our primary analysis compared PRR performance across all five groups matched for age, sex and IQ.
Compared to typically developing controls, probabilistic reversal learning was impaired in BD youths, with a trend in those with MDD (p=0.07).
Our results suggest that reversal learning deficits are present in youths with BD and possibly those with MDD. Further work is necessary to elucidate the specificity of neural mechanisms underlying such behavioral deficits.
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