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Increased amygdala-visual cortex connectivity in youth with persecutory ideation

  • Stephanie N. DeCross (a1) (a2), Amy H. Farabaugh (a1) (a3), Avram J. Holmes (a4), Maeve Ward (a1) (a5), Emily A. Boeke (a1) (a6), Rick P. F. Wolthusen (a1) (a7), Garth Coombs (a1) (a2), Maren Nyer (a1) (a3), Maurizio Fava (a1) (a3), Randy L. Buckner (a1) (a8) (a3) (a2) and Daphne J. Holt (a1) (a8) (a3)...

Subclinical delusional ideas, including persecutory beliefs, in otherwise healthy individuals are heritable symptoms associated with increased risk for psychotic illness, possibly representing an expression of one end of a continuum of psychosis severity. The identification of variation in brain function associated with these symptoms may provide insights about the neurobiology of delusions in clinical psychosis.


A resting-state functional magnetic resonance imaging scan was collected from 131 young adults with a wide range of severity of subclinical delusional beliefs, including persecutory ideas. Because of evidence for a key role of the amygdala in fear and paranoia, resting-state functional connectivity of the amygdala was measured.


Connectivity between the amygdala and early visual cortical areas, including striate cortex (V1), was found to be significantly greater in participants with high (n = 43) v. low (n = 44) numbers of delusional beliefs, particularly in those who showed persistence of those beliefs. Similarly, across the full sample, the number of and distress associated with delusional beliefs were positively correlated with the strength of amygdala-visual cortex connectivity. Moreover, further analyses revealed that these effects were driven by those who endorsed persecutory beliefs.


These findings are consistent with the hypothesis that aberrant assignments of threat to sensory stimuli may lead to the downstream development of delusional ideas. Taken together with prior findings of disrupted sensory-limbic coupling in psychosis, these results suggest that altered amygdala-visual cortex connectivity could represent a marker of psychosis-related pathophysiology across a continuum of symptom severity.

Corresponding author
Author for correspondence: Daphne J. Holt, E-mail:
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Amaral, DG, Behniea, H and Kelly, JL (2003) Topographic organization of projections from the amygdala to the visual cortex in the macaque monkey. Neuroscience 118, 10991120.
Anticevic, A, Repovs, G and Barch, DM (2011) Emotion effects on attention, amygdala activation, and functional connectivity in schizophrenia. Schizophrenia Bulletin 38, 967980.
Anticevic, A, Van Snellenberg, JX, Cohen, RE, Repovs, G, Dowd, EC and Barch, DM (2012) Amygdala recruitment in schizophrenia in response to aversive emotional material: a meta-analysis of neuroimaging studies. Schizophrenia Bulletin 38, 608621.
Anticevic, A, Tang, Y, Cho, YT, Repovs, G, Cole, MW, Savic, A, Wang, F, Krystal, JH and Xu, K (2014) Amygdala connectivity differs among chronic, early course, and individuals at risk for developing schizophrenia. Schizophrenia Bulletin 40, 11051116.
Beck, AT, Ward, CH, Mendelson, MM, Mock, JJ and Erbaugh, JJ (1961) An inventory for measuring depression. Archives of General Psychiatry 4, 561571.
Bentall, R and Slade, PD (1985) Reliability of a scale measuring disposition towards hallucination: a brief report. Personality and Individual Differences 6, 527529.
Bentall, RP, Rowse, G, Shryane, N, Kinderman, P, Howard, R, Blackwood, N, Moore, R and Corcoran, R (2009) The cognitive and affective structure of paranoid delusions: a transdiagnostic investigation of patients with schizophrenia spectrum disorders and depression. Archives of General Psychiatry 66, 236247.
Buckner, RL, Andrews-Hanna, JR and Schacter, DL (2008) The brain's default network. Annals of the New York Academy of Sciences 1124, 138.
Buckner, RL, Sepulcre, J, Talukdar, T, Krienen, FM, Liu, H, Hedden, T, Andrews-Hanna, JR, Sperling, RA and Johnson, KA (2009) Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. Journal of Neuroscience 29, 18601873.
Calkins, ME, Moore, TM, Merikangas, KR, Burstein, M, Satterthwaite, TD, Bilker, WB, Ruparel, K, Chiavacci, R, Wolf, DH, Mentch, F, Qiu, H, Connolly, JJ, Sleiman, PA, Hakonarson, H, Gur, RC and Gur, RE (2014) The psychosis spectrum in a young U.S. community sample: findings from the Philadelphia Neurodevelopmental Cohort. World Psychiatry 13, 296305.
Cannon, TD, Mednick, SA and Parnas, J (1990) Antecedents of predominantly negative-and predominantly positive-symptom schizophrenia in a high-risk population. Archives of General Psychiatry 47, 622632.
Cannon, TD, Yu, C, Addington, J, Bearden, CE, Cadenhead, KS, Cornblatt, BA, Heinssen, R, Jeffries, CD, Mathalon, DH, McGlashan, TH, Perkins, DO, Seidman, LJ, Tsuang, MT, Walker, EF, Woods, SW and Kattan, MW (2016) An individualized risk calculator for research in prodromal psychosis. American Journal of Psychiatry 173, 980988.
Cao, H, Bertolino, A, Walter, H, Schneider, M, Schafer, A, Taurisano, P, Blasi, G, Haddad, L, Grimm, O, Otto, K, Dixson, L, Erk, S, Mohnke, S, Heinz, A, Romanczuk-Seiferth, N, Muhleisen, TW, Mattheisen, M, Witt, SH, Cichon, S, Noethen, M, Rietschel, M, Tost, H and Meyer-Lindenberg, A (2016) Altered functional subnetwork during emotional face processing: a potential intermediate phenotype for schizophrenia. JAMA Psychiatry 73, 598605.
Capra, C, Kavanagh, DJ, Hides, L and Scott, J (2013) Brief screening for psychosis-like experiences. Schizophrenia Research 149, 104107.
Cella, M, Cooper, A, Dymond, SO and Reed, P (2008) The relationship between dysphoria and proneness to hallucination and delusions among young adults. Comprehensive Psychiatry 49, 544550.
Coombs, G III, Loggia, ML, Greve, DN and Holt, DJ (2014) Amygdala perfusion is predicted by its functional connectivity with the ventromedial prefrontal cortex and negative affect. PLOS ONE 9, e97466.
Cougnard, A, Marcelis, M, Myin-Germeys, I, De Graaf, R, Vollebergh, W, Krabbendam, L, Lieb, R, Wittchen, HU, Henquet, C, Spauwen, J and Van Os, J (2007) Does normal developmental expression of psychosis combine with environmental risk to cause persistence of psychosis? A psychosis proneness-persistence model. Psychological Medicine 37, 513527.
Cullen, KR, Westlund, MK, Klimes-Dougan, B, Mueller, BA, Houri, A, Eberly, LE and Lim, KO (2014) Abnormal amygdala resting-state functional connectivity in adolescent depression. JAMA Psychiatry 71, 11381147.
Cutting, J (1997) Principles of Psychopathology: Two Worlds, two Minds, two Hemispheres. Oxford, England, UK: Oxford University Press.
Das, P, Kemp, AH, Flynn, G, Harris, AW, Liddell, BJ, Whitford, TJ, Peduto, A, Gordon, E and Williams, LM (2007) Functional disconnections in the direct and indirect amygdala pathways for fear processing in schizophrenia. Schizophrenia Research 90, 284294.
Delgado, MR, Nearing, KI, Ledoux, JE and Phelps, EA (2008) Neural circuitry underlying the regulation of conditioned fear and its relation to extinction. Neuron 59, 829838.
Demjaha, A, Valmaggia, L, Stahl, D, Byrne, M and McGuire, P (2010) Disorganization/cognitive and negative symptom dimensions in the at-risk mental state predict subsequent transition to psychosis. Schizophrenia Bulletin 38, 351359.
Dominguez, MD, Wichers, M, Lieb, R, Wittchen, HU and van Os, J (2011) Evidence that onset of clinical psychosis is an outcome of progressively more persistent subclinical psychotic experiences: an 8-year cohort study. Schizophrenia Bulletin 37, 8493.
Farabaugh, A, Bitran, S, Nyer, M, Holt, DJ, Pedrelli, P, Shyu, I, Hollon, SD, Zisook, S, Baer, L, Busse, W, Petersen, TJ, Pender, M, Tucker, DD and Fava, M (2012) Depression and suicidal ideation in college students. Psychopathology 45, 228234.
Ford, JM, Palzes, VA, Roach, BJ, Potkin, SG, van Erp, TG, Turner, JA, Mueller, BA, Calhoun, VD, Voyvodic, J, Belger, A, Bustillo, J, Vaidya, JG, Preda, A, McEwen, SC, Functional Imaging Biomedical Informatics Research Network and Mathalon, DH (2015) Visual hallucinations are associated with hyperconnectivity between the amygdala and visual cortex in people with a diagnosis of schizophrenia. Schizophrenia Bulletin 41, 223232.
Fox, MD, Zhang, D, Snyder, AZ and Raichle, ME (2009) The global signal and observed anticorrelated resting state brain networks. Journal of Neurophysiology 101, 32703283.
Freeman, D (2006) Delusions in the nonclinical population. Current Psychiatry Reports 8, 191204.
Freeman, D (2007) Suspicious minds: the psychology of persecutory delusions. Clinical Psychology Review 27, 425457.
Freeman, D, Garety, PA, Kuipers, E, Fowler, D and Bebbington, PE (2002) A cognitive model of persecutory delusions. British Journal of Clinical Psychology 41, 331347.
Freese, JL and Amaral, DG (2005) The organization of projections from the amygdala to visual cortical areas TE and V1 in the macaque monkey. Journal of Comparative Neurology 486, 295317.
Friston, KJ and Frith, CD (1995) Schizophrenia: a disconnection syndrome? Journal of Clinical Neuroscience 3, 8997.
Fusar-Poli, P, McGuire, P and Borgwardt, S (2012) Mapping prodromal psychosis: a critical review of neuroimaging studies. European Psychiatry 27, 181191.
Gur, RE, McGrath, C, Chan, RM, Schroeder, L, Turner, T, Turetsky, BI, Kohler, C, Alsop, D, Maldjian, J, Ragland, JD and Gur, RC (2002) An fMRI study of facial emotion processing in patients with schizophrenia. American Journal of Psychiatry 159, 19921999.
Ho, B-C, Nopoulos, P, Flaum, M, Arndt, S and Andreasen, NC (1998) Two-year outcome in first-episode schizophrenia: predictive value of symptoms for quality of life. American Journal of Psychiatry 155, 11961201.
Holmes, AJ, Hollinshead, MO, O'Keefe, TM, Petrov, VI, Fariello, GR, Wald, LL, Fischl, B, Rosen, BR, Mair, RW, Roffman, JL, Smoller, JW and Buckner, RL (2015) Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures. Scientific Data 2, 150031.
Holt, DJ, Kunkel, L, Weiss, AP, Goff, DC, Wright, CI, Shin, LM, Rauch, SL, Hootnick, J and Heckers, S (2006) Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia. Schizophrenia Research 82, 153162.
Iwai, E and Yukie, M (1987) Amygdalofugal and amygdalopetal connections with modality-specific visual cortical areas in macaques (Macaca fuscata, M. mulatta, and M. fasicularis). Journal of Comparative Neurology 261, 362387.
Javitt, DC (2009) When doors of perception close: bottom-up models of disrupted cognition in schizophrenia. Annual Review of Clinical Psychology 5, 249275.
Kapur, S (2003) Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. American Journal of Psychiatry 160, 1323.
Karlsgodt, KH, Sun, D and Cannon, TD (2010) Structural and functional brain abnormalities in schizophrenia. Current Directions in Psychological Science 19, 226231.
Kaymaz, N, Drukker, M, Lieb, R, Wittchen, HU, Werbeloff, N, Weiser, M, Lataster, T and van Os, J (2012) Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results. Psychological Medicine 42, 22392253.
Kelleher, I and Cannon, M (2011) Psychotic-like experiences in the general population: characterizing a high-risk group for psychosis. Psychological Medicine 41, 16.
Kelleher, I, Connor, D, Clarke, MC, Devlin, N, Harley, M and Cannon, M (2012) Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies. Psychological Medicine 42, 18571863.
Kim, Y, Chang, JS, Hwang, S, Yi, JS, Cho, IH, Jung, HY (2013) Psychometric properties of Peters et al. Delusions Inventory-21 in adolescence. Psychiatry Research 207, 189194.
Kosaka, H, Omori, M, Murata, T, Iidaka, T, Yamada, H, Okada, T, Takahashi, T, Sadato, N, Itoh, H, Yonekura, Y and Wada, Y (2002) Differential amygdala response during facial recognition in patients with schizophrenia: an fMRI study. Schizophrenia Research 57, 8795.
Kraehenmann, R, Schmidt, A, Friston, K, Preller, KH, Seifritz, E and Vollenweider, FX (2016) The mixed serotonin receptor agonist psilocybin reduces threat-induced modulation of amygdala connectivity. NeuroImage: Clinical 11, 5360.
LeDoux, J (2003) The emotional brain, fear, and the amygdala. Cellular and Molecular Neurobiology 23, 727738.
Lee, TS (2002) Top-down influence in early visual processing: a Bayesian perspective. Physiology & Behavior 77, 645650.
Liang, M, Zhou, Y, Jiang, T, Liu, Z, Tian, L, Liu, H and Hao, Y (2006) Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging. NeuroReport 17, 209213.
Linscott, RJ and van Os, J (2013) An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: on the pathway from proneness to persistence to dimensional expression across mental disorders. Psychological Medicine 43, 11331149.
Maher, B (2005) Delusional thinking and cognitive disorder. Integrative Psychological and Behavioral Science 40, 136146.
Marshall, M, Lewis, S, Lockwood, A, Drake, R, Jones, P and Croudace, T (2005) Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Archives of General Psychiatry 62, 975983.
Menon, V, Anagnoson, R, Mathalon, D, Glover, G and Pfefferbaum, A (2001) Functional neuroanatomy of auditory working memory in schizophrenia: relation to positive and negative symptoms. NeuroImage 13, 433446.
Murphy, K, Birn, RM, Handwerker, DA, Jones, TB and Bandettini, PA (2009) The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? NeuroImage 44, 893905.
Nyer, M, Farabaugh, A, Fehling, K, Soskin, D, Holt, D, Papakostas, GI, Pedrelli, P, Fava, M, Pisoni, A, Vitolo, O and Mischoulon, D (2013) Relationship between sleep disturbance and depression, anxiety, and functioning in college students. Depression and Anxiety 30, 873880.
Peters, ER, Joseph, SA, Garety, PA (1999) Measurement of delusional ideation in the normal population: introducing the PDI (Peters et al. Delusions Inventory). Schizophrenia Bulletin 25, 553576.
Peters, ER, Joseph, SA, Day, S, Garety, PA (2004) Measuring delusional ideation: the 21-item Peters et al. Delusions Inventory (PDI). Schizophrenia Bulletin 30, 1005.
Phelps, EA (2006) Emotion and cognition: insights from studies of the human amygdala. Annual Review of Psychology 57, 2753.
Pinkham, AE, Liu, P, Lu, H, Kriegsman, M, Simpson, C and Tamminga, C (2015) Amygdala hyperactivity at rest in paranoid individuals with schizophrenia. American Journal of Psychiatry 172, 784792.
Pinkham, AE, Harvey, PD and Penn, DL (2016) Paranoid individuals with schizophrenia show greater social cognitive bias and worse social functioning than non-paranoid individuals with schizophrenia. Schizophrenia Research: Cognition 3, 3338.
Poulton, R, Caspi, A, Moffitt, TE, Cannon, M, Murray, R and Harrington, H (2000) Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Archives of General Psychiatry 57, 10531058.
Preti, A, Bonventre, E, Ledda, V, Petretto, DR and Masala, C (2007a) Hallucinatory experiences, delusional thought proneness, and psychological distress in a nonclinical population. The Journal of Nervous and Mental Disease 195, 484491.
Preti, A, Rocchi, MB, Sisti, D, Mura, T, Manca, S, Siddi, S, Petretto, DR, Masala, C (2007b) The psychometric discriminative properties of the Peters et al. Delusions Inventory: a receiver operating characteristic curve analysis. Comprehensive Psychiatry 48, 6269.
Rasetti, R, Mattay, VS, Wiedholz, LM, Kolachana, BS, Hariri, AR, Callicott, JH, Meyer-Lindenberg, A and Weinberger, DR (2009) Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk. American Journal of Psychiatry 166, 216225.
Ronald, A, Sieradzka, D, Cardno, AG, Haworth, CM, McGuire, P and Freeman, D (2014) Characterization of psychotic experiences in adolescence using the specific psychotic experiences questionnaire: findings from a study of 5000 16-year-old twins. Schizophrenia Bulletin 40, 868877.
Roy, AK, Shehzad, Z, Margulies, DS, Kelly, AC, Uddin, LQ, Gotimer, K, Biswal, BB, Castellanos, FX and Milham, MP (2009) Functional connectivity of the human amygdala using resting state fMRI. NeuroImage 45, 614626.
Ruhrmann, S, Schultze-Lutter, F, Salokangas, RK, Heinimaa, M, Linszen, D, Dingemans, P, Birchwood, M, Patterson, P, Juckel, G and Heinz, A (2010) Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis study. Archives of General Psychiatry 67, 241251.
Russell, TA, Reynaud, E, Kucharska-Pietura, K, Ecker, C, Benson, PJ, Zelaya, F, Giampietro, V, Brammer, M, David, A and Phillips, ML (2007) Neural responses to dynamic expressions of fear in schizophrenia. Neuropsychologia 45, 107123.
Sarpal, DK, Robinson, DG, Lencz, T, Argyelan, M, Ikuta, T, Karlsgodt, K, Gallego, JA, Kane, JM, Szeszko, PR and Malhotra, AK (2015) Antipsychotic treatment and functional connectivity of the striatum in first-episode schizophrenia. JAMA Psychiatry 72, 513.
Satterthwaite, TD, Vandekar, SN, Wolf, DH, Bassett, DS, Ruparel, K, Shehzad, Z, Craddock, RC, Shinohara, RT, Moore, TM, Gennatas, ED, Jackson, C, Roalf, DR, Milham, MP, Calkins, ME, Hakonarson, H, Gur, RC and Gur, RE (2015) Connectome-wide network analysis of youth with psychosis-spectrum symptoms. Molecular Psychiatry 20, 15081515.
Schmidt, A, Smieskova, R, Aston, J, Simon, A, Allen, P, Fusar-Poli, P, McGuire, PK, Riecher-Rössler, A, Stephan, KE and Borgwardt, S (2013) Brain connectivity abnormalities predating the onset of psychosis: correlation with the effect of medication. JAMA Psychiatry 70, 903912.
Schneider, F, Weiss, U, Kessler, C, Salloum, JB, Posse, S, Grodd, W and Muller-Gartner, HW (1998) Differential amygdala activation in schizophrenia during sadness. Schizophrenia Research 34, 133142.
Scott, J, Welham, J, Martin, G, Bor, W, Najman, J, O'Callaghan, M, Williams, G, Aird, R and McGrath, J (2008) Demographic correlates of psychotic-like experiences in young Australian adults. Acta Psychiatrica Scandinavica 118, 230237.
Scott, J, Martin, G, Welham, J, Bor, W, Najman, J, O'Callaghan, M, Williams, G, Aird, R and McGrath, J (2009) Psychopathology during childhood and adolescence predicts delusional-like experiences in adults: a 21-year birth cohort study. American Journal of Psychiatry 166, 567574.
Shaffer, JJ, Peterson, MJ, McMahon, MA, Bizzell, J, Calhoun, V, van Erp, TG, Ford, JM, Lauriello, J, Lim, KO and Manoach, DS (2015) Neural correlates of schizophrenia negative symptoms: distinct subtypes impact dissociable brain circuits. Molecular Neuropsychiatry 1, 191200.
Sisti, D, Rocchi, MBL, Siddi, S, Mura, T, Manca, S, Preti, A and Petretto, DR (2012) Preoccupation and distress are relevant dimensions in delusional beliefs. Comprehensive Psychiatry 53, 10391043.
Spielberger, CD, Gorsuch, RL and Lushene, RE (1970) Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press.
Stephan, K, Magnotta, V, White, T, Arndt, S, Flaum, M, O'leary, D and Andreasen, N (2001) Effects of olanzapine on cerebellar functional connectivity in schizophrenia measured by fMRI during a simple motor task. Psychological Medicine 31, 10651078.
Stephan, KE, Friston, KJ and Frith, CD (2009) Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring. Schizophrenia Bulletin 35, 509527.
Tarbox, SI, Addington, J, Cadenhead, KS, Cannon, TD, Cornblatt, BA, Perkins, DO, Seidman, LJ, Tsuang, MT, Walker, EF, Heinssen, R, McGlashan, TH and Woods, SW (2013) Premorbid functional development and conversion to psychosis in clinical high-risk youths. Development and Psychopathology 25, 11711186.
Taylor, SF, Phan, KL, Britton, JC and Liberzon, I (2005) Neural response to emotional salience in schizophrenia. Neuropsychopharmacology 30, 984995.
Tigges, J, Walker, LC and Tigges, M (1983) Subcortical projections to the occipital and parietal lobes of the chimpanzee brain. Journal of Comparative Neurology 220, 106115.
Ungerleider, LG and Haxby, JV (1994) ‘What’ and ‘where’ in the human brain. Current Opinion in Neurobiology 4, 157165.
Van Dijk, KR, Hedden, T, Venkataraman, A, Evans, KC, Lazar, SW and Buckner, RL (2009) Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization. Journal of Neurophysiology 103, 297321.
Van Dijk, KRA, Sabuncu, MR and Buckner, RL (2012) The influence of head motion on intrinsic functional connectivity MRI. NeuroImage 59, 431438.
van Os, J and Linscott, RJ (2012) Introduction: the extended psychosis phenotype – relationship with schizophrenia and with ultrahigh risk status for psychosis. Schizophrenia Bulletin 38, 227230.
van Os, J, Verdoux, H, Maurice-Tison, S, Gay, B, Liraud, F, Salamon, R and Bourgeois, M (1999) Self-reported psychosis-like symptoms and the continuum of psychosis. Social Psychiatry and Psychiatric Epidemiology 34, 459463.
van Os, J, Linscott, RJ, Myin-Germeys, I, Delespaul, P and Krabbendam, L (2009) A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness-persistence-impairment model of psychotic disorder. Psychological Medicine 39, 179195.
Varghese, D, Scott, J and McGrath, J (2008) Correlates of delusion-like experiences in a non-psychotic community sample. Australian & New Zealand Journal of Psychiatry 42, 505508.
Verdoux, H, Maurice-Tison, S, Gay, B, Van Os, J, Salamon, R and Bourgeois, M (1998a) A survey of delusional ideation in primary-care patients. Psychological Medicine 28, 127134.
Verdoux, H, Van Os, J, Maurice-Tison, S, Gay, B, Salamon, R and Bourgeois, M (1998b) Is early adulthood a critical developmental stage for psychosis proneness? A survey of delusional ideation in normal subjects. Schizophrenia Research 29, 247254.
Verdoux, H, van Os, J, Maurice-Tison, S, Gay, B, Salamon, R and Bourgeois, ML (1999) Increased occurrence of depression in psychosis-prone subjects: a follow-up study in primary care settings. Comprehensive Psychiatry 40, 462468.
Vuilleumier, P, Richardson, MP, Armony, JL, Driver, J and Dolan, RJ (2004) Distant influences of amygdala lesion on visual cortical activation during emotional face processing. Nature Neuroscience 7, 12711278.
Whitfield-Gabrieli, S and Ford, JM (2012) Default mode network activity and connectivity in psychopathology. Annual Review of Clinical Psychology 8, 4976.
Wigman, JT, Vollebergh, WA, Raaijmakers, QA, Iedema, J, van Dorsselaer, S, Ormel, J, Verhulst, FC and van Os, J (2011) The structure of the extended psychosis phenotype in early adolescence – a cross-sample replication. Schizophrenia Bulletin 37, 850860.
Williams, LM, Das, P, Harris, AW, Liddell, BB, Brammer, MJ, Olivieri, G, Skerrett, D, Phillips, ML, David, AS, Peduto, A and Gordon, E (2004) Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. American Journal of Psychiatry 161, 480489.
Wolf, DH, Satterthwaite, TD, Calkins, ME, Ruparel, K, Elliott, MA, Hopson, RD, Jackson, CT, Prabhakaran, K, Bilker, WB, Hakonarson, H, Gur, RC and Gur, RE (2015) Functional neuroimaging abnormalities in youth with psychosis spectrum symptoms. JAMA Psychiatry 72, 456465.
Yeo, BTT, Krienen, FM, Sepulcre, J, Sabuncu, MR, Lashkari, D, Hollinshead, M, Roffman, JL, Smoller, JW, Zöllei, L, Polimeni, JR, Fischl, B, Liu, H and Buckner, RL (2011) The organization of the human cerebral cortex estimated by intrinsic functional connectivity. Journal of Neurophysiology 106, 11251165.
Yung, AR, Phillips, LJ, Yuen, HP, Francey, SM, McFarlane, CA, Hallgren, M and McGorry, PD (2003) Psychosis prediction: 12-month follow up of a high-risk (‘prodromal’) group. Schizophrenia Research 60, 2132.
Yung, AR, Nelson, B, Baker, K, Buckby, JA, Baksheev, G and Cosgrave, EM (2009) Psychotic-like experiences in a community sample of adolescents: implications for the continuum model of psychosis and prediction of schizophrenia. Australian & New Zealand Journal of Psychiatry 43, 118128.
Zavos, HM, Freeman, D, Haworth, CM, McGuire, P, Plomin, R, Cardno, AG and Ronald, A (2014) Consistent etiology of severe, frequent psychotic experiences and milder, less frequent manifestations: a twin study of specific psychotic experiences in adolescence. JAMA Psychiatry 71, 10491057.
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