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    Li, Alexander H Morrison, Alanna C Kovar, Christie Cupples, L Adrienne Brody, Jennifer A Polfus, Linda M Yu, Bing Metcalf, Ginger Muzny, Donna Veeraraghavan, Narayanan Liu, Xiaoming Lumley, Thomas Mosley, Thomas H Gibbs, Richard A and Boerwinkle, Eric 2015. Analysis of loss-of-function variants and 20 risk factor phenotypes in 8,554 individuals identifies loci influencing chronic disease. Nature Genetics, Vol. 47, Issue. 6, p. 640.


    Wang, Jen-Chyong Kapoor, Manav and Goate, Alison M. 2012. The Genetics of Substance Dependence. Annual Review of Genomics and Human Genetics, Vol. 13, Issue. 1, p. 241.


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Linkage scan of nicotine dependence in the University of California, San Francisco (UCSF) Family Alcoholism Study

  • I. R. Gizer (a1) (a2), C. L. Ehlers (a3), C. Vieten (a4), K. L. Seaton-Smith (a1), H. S. Feiler (a5), J. V. Lee (a6), S. K. Segall (a1), D. A. Gilder (a3) and K. C. Wilhelmsen (a1) (a2) (a7)
  • DOI: http://dx.doi.org/10.1017/S0033291710001273
  • Published online: 01 July 2010
Abstract
Background

Nicotine dependence has been shown to represent a heritable condition, and several research groups have performed linkage analysis to identify genomic regions influencing this disorder though only a limited number of the findings have been replicated.

Method

In the present study, a genome-wide linkage scan for nicotine dependence was conducted in a community sample of 950 probands and 1204 relatives recruited through the University of California, San Francisco (UCSF) Family Alcoholism Study. A modified version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) with additional questions that probe nicotine use was used to derive DSM-IV nicotine dependence diagnoses.

Results

A locus on chromosome 2q31.1 at 184 centiMorgans nearest to marker D2S2188 yielded a logarithm (base 10) of odds (LOD) score of 3.54 (point-wise empirical p=0.000012). Additional peaks of interest were identified on chromosomes 2q13, 4p15.33-31, 11q25 and 12p11.23-21. Follow-up analyses were conducted examining the contributions of individual nicotine dependence symptoms to the chromosome 2q31.1 linkage peak as well as examining the relationship of this chromosomal region to alcohol dependence.

Conclusions

The present report suggests that chromosome 2q31.1 confers risk to the development of nicotine dependence and that this region influences a broad range of nicotine dependence symptoms rather than a specific facet of the disorder. Further, the results show that this region is not linked to alcohol dependence in this population, and thus may influence nicotine dependence specifically.

Copyright
Corresponding author
*Address for correspondence: I. R. Gizer, Ph.D., University of North Carolina at Chapel Hill, 120 Mason Farm Road, Room 5015 Genetic Medicine Building CB 7264, Chapel Hill, NC27599-7264, USA. (Email: igizer@unc.edu)
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