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Misattribution of sensory input reflected in dysfunctional target[ratio ]non-target ERPs in schizophrenia

Published online by Cambridge University Press:  16 November 2000

K. BROWN ,
E. GORDON ,
L. WILLIAMS ,
H. BAHRAMALI ,
A. HARRIS ,
J. GRAY ,
C. GONSALVEZ  and
R. MEARES
K. BROWN
Affiliation:
Brain Dynamics Centre, Department of Psychological Medicine, Westmead Hospital, Westmead, Department of Psychology, University of Sydney, Cumberland Hospital, Parramatta and Department of Psychology, Wollongong University, Wollongong, NSW, Australia; and Department of Psychology, Institute of Psychiatry, London
E. GORDON
Affiliation:
Brain Dynamics Centre, Department of Psychological Medicine, Westmead Hospital, Westmead, Department of Psychology, University of Sydney, Cumberland Hospital, Parramatta and Department of Psychology, Wollongong University, Wollongong, NSW, Australia; and Department of Psychology, Institute of Psychiatry, London
L. WILLIAMS
Affiliation:
Brain Dynamics Centre, Department of Psychological Medicine, Westmead Hospital, Westmead, Department of Psychology, University of Sydney, Cumberland Hospital, Parramatta and Department of Psychology, Wollongong University, Wollongong, NSW, Australia; and Department of Psychology, Institute of Psychiatry, London
H. BAHRAMALI
Affiliation:
Brain Dynamics Centre, Department of Psychological Medicine, Westmead Hospital, Westmead, Department of Psychology, University of Sydney, Cumberland Hospital, Parramatta and Department of Psychology, Wollongong University, Wollongong, NSW, Australia; and Department of Psychology, Institute of Psychiatry, London
A. HARRIS
Affiliation:
Brain Dynamics Centre, Department of Psychological Medicine, Westmead Hospital, Westmead, Department of Psychology, University of Sydney, Cumberland Hospital, Parramatta and Department of Psychology, Wollongong University, Wollongong, NSW, Australia; and Department of Psychology, Institute of Psychiatry, London
J. GRAY
Affiliation:
Brain Dynamics Centre, Department of Psychological Medicine, Westmead Hospital, Westmead, Department of Psychology, University of Sydney, Cumberland Hospital, Parramatta and Department of Psychology, Wollongong University, Wollongong, NSW, Australia; and Department of Psychology, Institute of Psychiatry, London
C. GONSALVEZ
Affiliation:
Brain Dynamics Centre, Department of Psychological Medicine, Westmead Hospital, Westmead, Department of Psychology, University of Sydney, Cumberland Hospital, Parramatta and Department of Psychology, Wollongong University, Wollongong, NSW, Australia; and Department of Psychology, Institute of Psychiatry, London
R. MEARES
Affiliation:
Brain Dynamics Centre, Department of Psychological Medicine, Westmead Hospital, Westmead, Department of Psychology, University of Sydney, Cumberland Hospital, Parramatta and Department of Psychology, Wollongong University, Wollongong, NSW, Australia; and Department of Psychology, Institute of Psychiatry, London
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Abstract

Background. While numerous studies have found disturbances in the Event-Related Potentials (ERPs) of patients with schizophrenia linked to task relevant target stimuli (most notably a reduction in P300 amplitude), few have examined ERPs to task irrelevant non-targets. We hypothesize, from current models of dysfunction in information processing in schizophrenia, that there will be less difference between ERPs to targets and non-targets in patients with schizophrenia than in controls.

Methods. EEGs were recorded for 40 subjects with schizophrenia and 40 age and sex matched controls during an auditory oddball reaction time task. ERPs to the targets and non-targets immediately preceding the targets were averaged separately.

Results. There was a disturbance in ERPs to targets but also to non-targets (reduced N100 amplitude and earlier P200 latency) and the difference between target and non-target ERP components (N100 and P200 amplitude and P200 latency), was significantly reduced in the schizophrenic group compared with controls.

Conclusions. These findings suggest a disturbance in processing task relevant and irrelevant stimuli, consistent with Gray's (1998) hypothesis of misattributions in the ‘match[ratio ]mismatch’ of novel (target) and familiar (non-target) sensory input compared with stored information.

Type
Research Article
Information
Psychological Medicine , Volume 30 , Issue 6 , November 2000 , pp. 1443 - 1449
Copyright
© 2000 Cambridge University Press

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