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Neurobiological mechanisms of social cognition treatment in high-functioning adults with autism spectrum disorder

  • Gabriela Rosenblau (a1) (a2) (a3), Garret O'Connell (a4), Hauke R. Heekeren (a1) (a2) (a5) and Isabel Dziobek (a1) (a2) (a4)

Abstract

Background

The promise of precision medicine for autism spectrum disorder (ASD) hinges on developing neuroscience-informed individualized interventions. Taking an important step in this direction, we investigated neuroplasticity in response to an ecologically-valid, computer-based social-cognitive training (SCOTT).

Methods

In an active control group design, 48 adults with ASD were randomly assigned to a 3-month SCOTT or non-social computer training. Participants completed behavioral tasks, a functional and structural magnetic resonance imaging session before and after the training period.

Results

The SCOTT group showed social-cognitive improvements on close and distant generalization tasks. The improvements scaled with reductions in functional activity and increases in cortical thickness in prefrontal regions.

Conclusion

In sum, we provide evidence for the sensitivity of neuroscientific methods to reflect training-induced social-cognitive improvements in adults with ASD. These results encourage the use of neuroimaging data to describe and quantify treatment-related changes more broadly.

Copyright

Corresponding author

Author for correspondence: Gabriela Rosenblau, E-mail: grosenblau@gwu.edu

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Neurobiological mechanisms of social cognition treatment in high-functioning adults with autism spectrum disorder

  • Gabriela Rosenblau (a1) (a2) (a3), Garret O'Connell (a4), Hauke R. Heekeren (a1) (a2) (a5) and Isabel Dziobek (a1) (a2) (a4)

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