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Neuropsychiatric and neuropsychological correlates of delusions in Alzheimer's disease

  • R. Migliorelli (a1), G. Petracca (a1), A. Tesón (a1), L. Sabe (a1), R. Leiguarda (a1) and S. E. Starkstein (a1)
  • DOI:
  • Published online: 01 July 2009

We examined the prevalence, phenomenology, and clinical correlates of delusions in a consecutive series of 103 patients with probable Alzheimer's disease (AD). Patients were examined with the Present State Exam and the Dementia–Psychosis Scale. Twenty-one patients (20%) met DSM-III-R criteria for a delusional disorder. The most frequent delusion type was paranoid (71%), followed by hypochondriacal (67%), the Capgras syndrome (29%), house misidentification (29%), and grandiose delusions (29%). Out of the 21 AD patients with delusions, 76% had three or more different types of delusions simultaneously. The frequency of delusions was not significantly associated with age, education, or age at dementia onset, and the type and severity of cognitive impairments was similar for AD patients with and without delusions. However, AD patients with delusions had significantly higher mania and anosognosia scores.

Corresponding author
1 Address for correspondence: Dr Sergio E. Starkstein, Instituto de Investigaciones Neurológicas Raúl Carrea, Fleni, Montaneses 2325, 1428 Buenos Aires, Argentina.
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

G. E. Berrios & P. Brook (1985). Delusions and the psychopathology of the elderly with dementia. Acta Psychiatrica Scandinavica 72, 296301.

A. L. Benton (1968). Differential behavioral effects in frontal lobe disease. Neuropsychologia 6, 5360.

A. Burns , R. Jacoby & R. Levy (1990). Psychiatric phenomena in Alzheimer's disease. 1. Disorders of thought content. British Journal of Psychiatry 157, 7276.

H. Buschke & P. A. Fuld (1974). Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology 24, 10191025.

E. De Renzi & P. Faglioni (1978). Development of a shortened version of the Token Test. Cortex 14, 4149.

D. P. Devanand , L. Miller , M. Richards , K. Marder , K. Bell , R. Mayeux & Y. Stern (1992). The Columbia University Scale for psychopathology in Alzheimer's disease. Archives of Neurology 49, 371376.

W. C. Drevets & E. H. Rubin (1987). Erotomania and senile dementia of Alzheimer type. British Journal of Psychiatry 151, 400402.

W. C. Drevets & E. H. Rubin (1989). Psychotic symptoms and the longitudinal course of senile dementia of the Alzheimer type. Biological Psychiatry 25, 3948.

M. F. Folstein , S. E. Folstein & P. R. McHugh (1975). Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatry Research 12, 189198.

H. Förstl , A. Burns , P. Luthert , N. Cairns & R. Levy (1993). The Lewy-body variant of Alzheimer's disease: clinical and pathological findings. British Journal of Psychiatry 162, 385392.

V. Kumar (1987). Capgras syndrome in a patient with dementia. British Journal of Psychiatry 150, 251.

O. L. Lopez , J. T. Becker , R. P. Brenner , J. Rosen , O. I. Bajulaiye & C. F. Reynolds (1991). Alzheimer's disease with delusions and hallucinations: neuropsychological and electroencephalographic correlates. Neurology 41, 906912.

S. M. McGlynn & A. W. Kazniak (1991). When metacognition fails: impaired awareness of deficits in Alzheimer's disease. Journal of Cognitive Neuroscience 3, 183189.

G. McKhann , D. Drachman , M. F. Folstein , R. Katzman , D. Price & E. M. Stadlan (1984). Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939944.

R. Mayeux , Y. Stern & S. Spanton (1985). Heterogeneity in dementia of the Alzheimer type: evidence of subgroups. Neurology 35, 453461.

M. F. Mendez (1992). Delusional misidentification of persons in dementia. British Journal of Psychiatry 160, 414416.

M. F. Mendez , R. J. Martin , K. A. Smyth & P. J. Whitehouse (1992). Disturbances of person identification in Alzheimer's disease. Journal of Nervous and Mental Disease 180, 9496.

B. Mercer , W. Wapner , H. Gardner & D. F. Benson (1977). A study of confabulation. Archives of Neurology 34, 429433.

H. E. Nelson (1976). A modified card sorting test sensitive to frontal lobe defects. Cortex 12, 313324.

P. V. Rabins , N. L. Mace & M. J. Lucas (1982). The impact of dementia on the family. Journal of the American Medical Association 248, 333335.

R. M. Reitan (1958). Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual and Motor Skills 8, 271276.

E. B. Renvoize , J. Kent & H. M. Klar (1987). Delusional infestation and dementia: a case report. British Journal of Psychiatry 150, 403405.

R. L. Spitzer , J. B. W. Williams , M. Gibbon & M. B. First (1992). The structured clinical interview for DSM-III-R(SCID). I. History, rationale, and description. Archives of General Psychiatry 49, 624629.

S. E. Starkstein , H. S. Mayberg , M. L. Berthier , P. Fedoroff , T. R. Price , R. F. Dannals , H. N. Wagner , R. Leiguarda & R. G. Robinson (1990). Mania after brain injury: neuroradiological and metabolic findings. Annals of Neurology 27, 652659.

S. E. Starkstein , R. Migliorelli , A. Tesón , L. Sabe , S. Vazquez , M. Turjanski , R. G. Robinson & R. Leiguarda (1994). The specificity of cerebral blood flow changes in patients with frontal lobe dementia. Journal of Neurology, Neurosurgery and Psychiatry, 57, 790796.

Y. K. Stern , R. Mayeux , M. Sano , W. A. Hauser & T. Bush (1987). Predictors of disease course in patients with probable Alzheimer's disease. Neurology 37, 16491653.

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