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Parent–child conflict as an etiological moderator of childhood conduct problems: an example of a ‘bioecological’ gene–environment interaction

  • S. A. Burt (a1) and K. L. Klump (a1)

Prior research has suggested that, consistent with the diathesis–stress model of gene–environment interaction (G × E), parent–child conflict activates genetic influences on antisocial/externalizing behaviors during adolescence. It remains unclear, however, whether this model is also important during childhood, or whether the moderation of child conduct problems by negative/conflictive parenting is better characterized as a bioecological interaction, in which environmental influences are enhanced in the presence of environmental risk whereas genetic influences are expressed most strongly in their absence. The current study sought to distinguish between these possibilities, evaluating how the parent–child relationship moderates the etiology of childhood-onset conduct problems.


We conducted a series of ‘latent G by measured E’ interaction analyses, in which a measured environmental variable was allowed to moderate both genetic and environmental influences on child conduct problems. Participants included 500 child twin pairs from the Michigan State University Twin Registry (MSUTR).


Shared environmental influences on conduct problems were found to be several-fold larger in those with high levels of parent–child conflict as compared with those with low levels. Genetic influences, by contrast, were proportionally more influential at lower levels of conflict than at higher levels.


Our findings suggest that, although the diathesis–stress form of G × E appears to underlie the relationship between parenting and conduct problems during adolescence, this pattern of moderation does not extend to childhood. Instead, results were more consistent with the bioecological form of G × E which postulates that, in some cases, genetic influences may be most fully manifested in the absence of environmental risk.

Corresponding author
* Address for correspondence: S. A. Burt, Ph.D., Department of Psychology, Michigan State University, 107D Psychology Building, East Lansing, MI 48824 USA. (Email:
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TM Achenbach , SH McConaughy , CT Howell (1987). Child/adolescent behavioral and emotional problems: implications of cross-informant correlations for situational specificity. Psychological Bulletin 101, 213232.

H Akaike (1987). Factor analysis and AIC. Psychometrika 52, 317332.

L Arsenault , TE Moffitt , A Caspi , A Taylor , FV Rijsdijk , SR Jaffee , JC Ablow , JR Measelle (2003). Strong genetic effects on cross-situational antisocial behavior among 5-year-old children according to mothers, teachers, examiner-observers, and twins’ self-reports. Journal of Child Psychology and Psychiatry 44, 832848.

C Aslund , N Nordquist , E Comasco , J Leppert , L Oreland , KW Nilsson (2011). Maltreatment, MAOA, and delinquency: sex differences in gene–environment interaction in a large population-based cohort of adolescents. Behavior Genetics 41, 262272.

SRH Beach , GH Brody , TD Gunter , H Packer , P Wernett , RA Philibert (2010). Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. Journal of Family Psychology 24, 1220.

KM Beaver , M DeLisi , JP Wright , MG Vaughn (2009). Gene–environment interplay and delinquent involvement: evidence of direct, indirect, and interactive effects. Journal of Adolescent Research 24, 147168.

U Bronfenbrenner , SJ Ceci (1994). Nature–nurture reconceptualized in developmental perspective: a bioecological model. Psychological Review 101, 568586.

SA Burt (2009 a). Are there meaningful etiological differences within antisocial behavior? Results of a meta-analysis. Clinical Psychology Review 29, 163178.

SA Burt (2009 b). Rethinking environmental contributions to child and adolescent psychopathology: a meta-analysis of shared environmental influences. Psychological Bulletin 135, 608637.

SA Burt (2011). Some key issues in the study of gene–environment interplay: activation, deactivation, and the role of development. Research in Human Development 8, 192210.

SA Burt , AM Klahr , MA Rueter , M McGue , WG Iacono (2011). Confirming the etiology of adolescent acting-out behaviors: an examination of observer-ratings in a sample of adoptive and biological siblings. Journal of Child Psychology and Psychiatry 52, 519526.

SA Burt , RF Krueger , M McGue , WG Iacono (2003). Parent–child conflict and the comorbidity among childhood externalizing disorders. Archives of General Psychiatry 60, 505513.

SA Burt , M McGue , RF Krueger , WG Iacono (2005). How are parent–child conflict and child externalizing behaviors related over time? Results from a genetically-informative cross-lagged study. Development and Psychopathology 17, 121.

SA Burt , JM Neiderhiser (2009). Aggressive versus non-aggressive antisocial behavior: distinctive etiological moderation by age. Developmental Psychology 45, 11641176.

TMM Button , RP Corley , SH Rhee , JK Hewitt , SE Young , MC Stallings (2007). Delinquent peer affiliation and conduct problems: a twin study. Journal of Abnormal Psychology 116, 554564.

TMM Button , JYF Lau , B Maughan , TC Eley (2008). Parental punitive discipline, negative life events, and gene–environment interplay in the development of externalizing behavior. Psychological Medicine 38, 2939.

A Caspi , J McClay , TE Moffitt , J Mill , J Martin , IW Craig , A Taylor , R Poulton (2002). Role of violence in maltreated children. Science 297, 851854.

G Cumming , S Finch (2005). Inference by the eye: confidence intervals and how to read pictures of data. American Psychologist 60, 170180.

IJ Elkins , MK McGue , WG Iacono (1997). Genetic and environmental influences on parent–son relationships: evidence for increasing genetic influence during adolescence. Developmental Psychology 33, 351363.

ME Feinberg , TMM Button , JM Neiderhiser , EM Hetherington , D Reiss (2007). Parenting and adolescent antisocial behavior and depression: evidence for genotype by parenting interaction. Archives of General Psychiatry 64, 457465.

DL Foley , LJ Eaves , B Wormley , JL Silberg , HH Maes , J Kuhn , B Riley (2004). Childhood adversity, monoamine oxidase A genotype, and risk for conduct disorder. Archives of General Psychiatry 61, 738744.

G Gottlieb (2007). Probabilistic epigenesis. Development Science 10, 111.

PW Harden , JE Hill , E Turkheimer , RE Emery (2008). Gene–envrionment correlation and interaction on peer effects on adolescent alcohol and tobacco use. Behavior Genetics 38, 339347.

BM Hicks , SC South , AC DiRago , WG Iacono , M McGue (2009). Environmental adversity and increasing genetic risk for externalizing disorders. Archives of General Psychiatry 66, 640648.

KS Kendler , KC Jacobson , JM Myers , LJ Eaves (2008). A genetically informative developmental study of the relationship between conduct disorder and peer deviance in males. Psychological Medicine 38, 10011011.

J Kim-Cohen , A Caspi , A Taylor , B Williams , R Newcombe , IW Craig , TE Moffitt (2006). MAOA, maltreatment, and gene–environment interaction predicting children's mental health: new evidence and a meta-analysis. Molecular Psychiatry 11, 903913.

LN Legrand , MA Keyes , M McGue , WG Iacono , RF Krueger (2008). Rural environments reduce the gentic influence on adolescent substance use and rule-breaking behavior. Psychological Medicine 38, 13411350.

JJ Li , SS Lee (2010). Latent class analysis of antisocial behavior: interaction of serotonin transporter genotype and maltreatment. Journal of Abnormal Child Psychology 38, 789801.

MJ Lyons , WR True , SA Eisne , J Goldberg , JM Meyer , SV Faraone , L Eaves , MT Tsuang (1995). Differential heritability of adult and juvenile antisocial traits. Archives of General Psychiatry 52, 906915.

M McGue , TJJ Bouchard (1984). Adjustment of twin data for the effects of age and sex. Behavior Genetics 14, 325343.

TE Moffitt (1993). Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychological Review 100, 674701.

TE Moffitt , A Caspi , M Rutter (2006). Measured gene–environment interactions in psychopathology. Perspectives on Psychological Science 1, 527.

H Peeters , S Van Gestel , R Vlietinck , C Derom , R Derom (1998). Validation of a telephone zygosity questionnaire in twins of known zygosity. Behavior Genetics 28, 159161.

BF Pennington , LM McGrath , J Rosenberg , H Barnard , SD Smith , EG Willcutt , A Friend , JC DeFries , RK Olson (2009). Gene x environment interactions in reading disability and attention-deficit/hyperactivity disorder. Developmental Psychology 45, 7789.

R Plomin , JC DeFries , JC Loehlin (1977). Genotype–environment interaction and correlation in the analysis of human behavior. Psychological Bulletin 84, 309322.

S Purcell (2002). Variance components model for gene–environment interaction in twin analysis. Twin Research 5, 554571.

AE Raftery (1995). Bayesian model selection in social research. Sociological Methodology 25, 111163.

A Raine (2002). Biosocial studies of antisocial and violent behavior in children and adolescents: a review. Journal of Abnormal Child Psychology 30, 311326.

PJ Rathouz , CA Van Hulle , JL Rodgers , ID Waldman , BB Lahey (2008). Specification, testing, and interpretation of gene-by-measured-environment interaction models in the presence of gene–environment correlation. Behavior Genetics 38, 301315.

M Rutter , TE Moffitt , A Caspi (2006). Gene–environment interplay and psychopathology: multiple varieties but real effects. Journal of Child Psychology and Psychiatry 47, 226261.

S Scarr , K McCartney (1983). How people make their own environments: a theory of genotype–environment effects. Child Development 54, 424435.

C Spatz Widom , LM Brzustowicz (2006). MAOA and the “cycle of violence:” childhood abuse and neglect, MAOA genotype, and risk for violent and antisocial behavior. Biological Psychiatry 60, 684689.

DJ Spiegelhalter , NG Best , BP Carlin , A Van Der Linde (2002). Bayesian measures of model complexity and fit. Journal of the Royal Statistical Society: Series B 64, 583639.

S van der Sluis , D Posthuma , CV Dolan (2012). A note on false positives and power in GxE modeling of twin data. Behavior Genetics 42, 170186.

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Psychological Medicine
  • ISSN: 0033-2917
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