Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 21
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Frans, E. M. Lichtenstein, P. Hultman, C. M. and Kuja-Halkola, R. 2016. Age at fatherhood: heritability and associations with psychiatric disorders. Psychological Medicine, p. 1.


    Tearne, Jessica E. 2015. Older maternal age and child behavioral and cognitive outcomes: a review of the literature. Fertility and Sterility, Vol. 103, Issue. 6, p. 1381.


    Brown, Alan Bao, Yuanyuan McKeague, Ian Shen, Ling and Schaefer, Catherine 2013. Parental age and risk of bipolar disorder in offspring. Psychiatry Research, Vol. 208, Issue. 3, p. 225.


    Fechner, Adam J. and Al-Khan, Abdulla 2012. Care of the Older Pregnant Patient Part II. Postgraduate Obstetrics & Gynecology, Vol. 32, Issue. 11, p. 1.


    Byars, Sean G. and Boomsma, Jacobus J. 2016. Opposite differential risks for autism and schizophrenia based on maternal age, paternal age, and parental age differences. Evolution, Medicine, and Public Health, Vol. 2016, Issue. 1, p. 286.


    Smith, Kevin R 2015. Paternal age bioethics. Journal of Medical Ethics, Vol. 41, Issue. 9, p. 775.


    O'Shea, K. Sue and McInnis, Melvin G. 2016. Neurodevelopmental origins of bipolar disorder: iPSC models. Molecular and Cellular Neuroscience, Vol. 73, p. 63.


    Myrskylä, Mikko and Fenelon, Andrew 2012. Maternal Age and Offspring Adult Health: Evidence From the Health and Retirement Study. Demography, Vol. 49, Issue. 4, p. 1231.


    Chudal, Roshan Sucksdorff, Dan Suominen, Auli Lehti, Venla Hinkka-Yli-Salomäki, Susanna Huttunen, Jukka Ristkari, Terja Gissler, Mika Mckeague, Ian W. Brown, Alan S. and Sourander, Andre 2014. Finnish Prenatal Study of Bipolar Disorders (FIPS-B): Overview, design and description of the sample. Nordic Journal of Psychiatry, Vol. 68, Issue. 3, p. 169.


    Sharma, Rakesh Agarwal, Ashok Rohra, Vikram K Assidi, Mourad Abu-Elmagd, Muhammad and Turki, Rola F 2015. Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring. Reproductive Biology and Endocrinology, Vol. 13, Issue. 1,


    Laurens, Kristin R. Luo, Luming Matheson, Sandra L. Carr, Vaughan J. Raudino, Alessandra Harris, Felicity and Green, Melissa J. 2015. Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses. BMC Psychiatry, Vol. 15, Issue. 1,


    Grigoroiu-Serbanescu, Maria Wickramaratne, Priya J. Mihailescu, Radu Prelipceanu, Dan Sima, Dorina Codreanu, Marina Grimberg, Mihaela and Elston, Robert C. 2012. Paternal age effect on age of onset in bipolar I disorder is mediated by sex and family history. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 159B, Issue. 5, p. 567.


    Adler, Scott A. and Wong-Kee-You, Audrey M. B. 2015. Differential attentional responding in caesarean versus vaginally delivered infants. Attention, Perception, & Psychophysics, Vol. 77, Issue. 8, p. 2529.


    Buizer-Voskamp, Jacobine E. Laan, Wijnand Staal, Wouter G. Hennekam, Eric A.M. Aukes, Maartje F. Termorshuizen, Fabian Kahn, René S. Boks, Marco P.M. and Ophoff, Roel A. 2011. Paternal age and psychiatric disorders: Findings from a Dutch population registry. Schizophrenia Research, Vol. 129, Issue. 2-3, p. 128.


    Sucksdorff, Dan Chudal, Roshan Suominen, Auli Jokiranta, Elina Brown, Alan S. and Sourander, Andre 2014. Bipolar disorder and parental psychopathology. Social Psychiatry and Psychiatric Epidemiology, Vol. 49, Issue. 12, p. 1973.


    Kaminsky, Z Tochigi, M Jia, P Pal, M Mill, J Kwan, A Ioshikhes, I Vincent, J B Kennedy, J L Strauss, J Pai, S Wang, S-C and Petronis, A 2012. A multi-tissue analysis identifies HLA complex group 9 gene methylation differences in bipolar disorder. Molecular Psychiatry, Vol. 17, Issue. 7, p. 728.


    Adkins, Ronald M Thomas, Fridtjof Tylavsky, Frances A and Krushkal, Julia 2011. Parental ages and levels of DNA methylation in the newborn are correlated. BMC Medical Genetics, Vol. 12, Issue. 1,


    Tearne, Jessica E. Robinson, Monique Jacoby, Peter Li, Jianghong Newnham, John and McLean, Neil 2015. Does Late Childbearing Increase the Risk for Behavioural Problems in Children? A Longitudinal Cohort Study. Paediatric and Perinatal Epidemiology, Vol. 29, Issue. 1, p. 41.


    Bjorngaard, J. H. Bjerkeset, O. Vatten, L. Janszky, I. Gunnell, D. and Romundstad, P. 2013. Maternal Age at Child Birth, Birth Order, and Suicide at a Young Age: A Sibling Comparison. American Journal of Epidemiology, Vol. 177, Issue. 7, p. 638.


    Chudal, Roshan Gissler, Mika Sucksdorff, Dan Lehti, Venla Suominen, Auli Hinkka-Yli-Salomäki, Susanna Brown, Alan S and Sourander, Andre 2014. Parental age and the risk of bipolar disorders. Bipolar Disorders, Vol. 16, Issue. 6, p. 624.


    ×

Paternal and maternal ages at conception and risk of bipolar affective disorder in their offspring

  • P. R. Menezes (a1) (a2), G. Lewis (a2), F. Rasmussen (a3), S. Zammit (a2) (a4), A. Sipos (a2), G. L. Harrison (a2), P. Tynelius (a3) and D. Gunnell (a5)
  • DOI: http://dx.doi.org/10.1017/S003329170999064X
  • Published online: 23 July 2009
Abstract
Background

A consistent association between paternal age and their offspring's risk of schizophrenia has been observed, with no independent association with maternal age. The relationship of paternal and maternal ages with risk of bipolar affective disorders (BPAD) in the offspring is less clear. The present study aimed at testing the hypothesis that paternal age is associated with their offspring's risk of BPAD, whereas maternal age is not.

Method

This population-based cohort study was conducted with individuals born in Sweden during 1973–1980 and still resident there at age 16 years. Outcome was first hospital admission with a diagnosis of BPAD. Hazard ratios (HRs) were calculated using Cox's proportional hazard regression.

Results

After adjustment for all potential confounding variables except maternal age, the HR for risk of BPAD for each 10-year increase in paternal age was 1.28 [95% confidence interval (CI) 1.11–1.48], but this fell to 1.20 (95% CI 0.97–1.48) after adjusting for maternal age. A similar result was found for maternal age and risk of BPAD [HR 1.30 (95% CI 1.08–1.56) before adjustment for paternal age, HR 1.12 (95% CI 0.86–1.45) after adjustment]. The HR associated with having either parent aged 30 years or over was 1.26 (95% CI 1.01–1.57) and it was 1.45 (95% CI 1.16–1.81) if both parents were >30 years.

Conclusions

Unlike schizophrenia, the risk of BPAD seems to be associated with both paternal and maternal ages.

Copyright
Corresponding author
*Address for correspondence: Professor F. Rasmussen, Child and Adolescent Public Health Epidemiology Group, Department of Public Health Sciences, Karolinska Institute, SE-17176Stockholm, Sweden. (Email: finn.rasmussen@ki.se)
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

O Agid , B Shapira , J Zislin , M Ritsner , B Hanin , H Murad , T Troudart , M Bloch , U Heresco-Levy , B Lerer (1999). Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia. Molecular Psychiatry 4, 163172.

AS Brown , CA Schaefer , RJ Wyatt , MD Begg , R Goetz , MA Bresnahan , J Harkavy-Friedman , JM Gorman , D Malaspina , ES Susser (2002). Paternal age and risk of schizophrenia in adult offspring. American Journal of Psychiatry 159, 15281533.

M Byrne , E Agerbo , H Ewald , WW Eaton , PB Mortensen (2003). Parental age and risk of schizophrenia: a case–control study. Archives of General Psychiatry 60, 673678.

JY Choi , KM Lee , SK Park , DY Noh , SH Ahn , KY Yoo , D Kang (2005). Association of paternal age at birth and the risk of breast cancer in offspring: a case control study. BMC Cancer 5, 143.

N Craddock , MC O'Donovan , MJ Owen (2006). Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophrenia Bulletin 32, 9–16.

JF Crow (1997). The high spontaneous mutation rate: is it a health risk? Proceedings of the National Academy of Sciences USA 94, 83808386.

JF Crow (2000). The origins, patterns and implications of human spontaneous mutation. Nature Reviews Genetics 1, 4047.


O El-Saadi , CB Pedersen , TF McNeil , S Saha , J Welham , E O'Callaghan , E Cantor-Graae , D Chant , PB Mortensen , J McGrath (2004). Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia. Schizophrenia Research 67, 227236.

A Farmer , A Elkin , P McGuffin (2007). The genetics of bipolar affective disorder. Current Opinion in Psychiatry 20, 8–12.

RL Glaser , EW Jabs (2004). Dear old dad. Science of Aging Knowledge Environment 2004, re1.

S Harlap , O Paltiel , L Deutsch , A Knaanie , S Masalha , E Tiram , LS Caplan , D Malaspina , Y Friedlander (2002). Paternal age and preeclampsia. Epidemiology 13, 660667.


D Malaspina , C Corcoran , C Fahim , A Berman , J Harkavy-Friedman , S Yale , D Goetz , R Goetz , S Harlap , J Gorman (2002). Paternal age and sporadic schizophrenia: evidence for de novo mutations. American Journal of Medical Genetics 114, 299303.

D Malaspina , S Harlap , S Fennig , D Heiman , D Nahon , D Feldman , ES Susser (2001). Advancing paternal age and the risk of schizophrenia. Archives of General Psychiatry 58, 361367.

C Morgan , J Kirkbride , J Leff , T Craig , G Hutchinson , K McKenzie , K Morgan , P Dazzan , GA Doody , P Jones , R Murray , P Fearon (2007). Parental separation, loss and psychosis in different ethnic groups: a case–control study. Psychological Medicine 37, 495503.

A Reichenberg , R Gross , M Weiser , M Bresnahan , J Silverman , S Harlap , J Rabinowitz , C Shulman , D Malaspina , G Lubin , HY Knobler , M Davidson , E Susser (2006). Advancing paternal age and autism. Archives of General Psychiatry 63, 10261032.

NE Reichman , JO Teitler (2006). Paternal age as a risk factor for low birthweight. American Journal of Public Health 96, 862866.

KJ Rothman , S Greenland (1998). Modern Epidemiology. Lippincott-Raven: Philadelphia, PA.

RA Shih , PL Belmonte , PP Zandi (2004). A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders. International Review of Psychiatry 16, 260283.

A Sipos , F Rasmussen , G Harrison , P Tynelius , G Lewis , DA Leon , D Gunnell (2004). Paternal age and schizophrenia: a population based cohort study. British Medical Journal 329, 10701074.

M Wohl , P Gorwood (2007). Paternal ages below or above 35 years old are associated with a different risk of schizophrenia in the offspring. European Psychiatry 22, 2226.

Q Yang , SW Wen , A Leader , XK Chen , J Lipson , M Walker (2007). Paternal age and birth defects: how strong is the association? Human Reproduction 22, 696701.

S Zammit , P Allebeck , C Dalman , I Lundberg , T Hemmingson , MJ Owen , G Lewis (2003). Paternal age and risk for schizophrenia. British Journal of Psychiatry 183, 405408.

JL Zhu , KM Madsen , M Vestergaard , AV Olesen , O Basso , J Olsen (2005). Paternal age and congenital malformations. Human Reproduction 20, 31733177.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: