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The pathophysiology of extrapyramidal side-effects of neuroleptic drugs

Published online by Cambridge University Press:  09 July 2009

C. D. Marsden  and
P. Jenner
C. D. Marsden*
Affiliation:
University Department of Neurology, Institute of Psychiatry, and King's College Hospital Medical School, London
P. Jenner
Affiliation:
University Department of Neurology, Institute of Psychiatry, and King's College Hospital Medical School, London
*
1Address for correspondence: Professor C. D. Marsden, University Department of Neurology, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF.
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Synopsis

The mechanisms responsible for the production of major extrapyramidal side-effects (parkinsonism, akathisia, acute dystonic reactions, chronic tardive dyskinesias) are reviewed in the light of the complex effects of these drugs on cerebral dopamine systems.

Information

Type
Research Article
Information
Psychological Medicine , Volume 10 , Issue 1 , February 1980 , pp. 55 - 72
Copyright
Copyright © Cambridge University Press 1980

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