Wu, Zhao-Min Bralten, Janita An, Li Cao, Qing-Jiu Cao, Xiao-Hua Sun, Li Liu, Lu Yang, Li Mennes, Maarten Zang, Yu-Feng Franke, Barbara Hoogman, Martine and Wang, Yu-Feng 2017. Verbal working memory-related functional connectivity alterations in boys with attention-deficit/hyperactivity disorder and the effects of methylphenidate. Journal of Psychopharmacology, Vol. 31, Issue. 8, p. 1061.
Faraone, Stephen V. Ghirardi, Laura Kuja-Halkola, Ralf Lichtenstein, Paul and Larsson, Henrik 2017. The Familial Co-Aggregation of Attention-Deficit/Hyperactivity Disorder and Intellectual Disability: A Register-Based Family Study. Journal of the American Academy of Child & Adolescent Psychiatry, Vol. 56, Issue. 2, p. 167.
Doyle, Alysa E. Vuijk, Pieter J. Doty, Nathan D. McGrath, Lauren M. Willoughby, Brian L. O’Donnell, Ellen H. Wilson, H. Kent Colvin, Mary K. Toner, Deanna C. Hudson, Kelsey E. Blais, Jessica E. Ditmars, Hillary L. Faraone, Stephen V. Seidman, Larry J. and Braaten, Ellen B. 2017. Cross-Disorder Cognitive Impairments in Youth Referred for Neuropsychiatric Evaluation. Journal of the International Neuropsychological Society, p. 1.
Cheung, Celeste H. M. McLoughlin, Gráinne Brandeis, Daniel Banaschewski, Tobias Asherson, Philip and Kuntsi, Jonna 2017. Neurophysiological Correlates of Attentional Fluctuation in Attention-Deficit/Hyperactivity Disorder. Brain Topography, Vol. 30, Issue. 3, p. 320.
Moore, Tyler M. Gur, Ruben C. Thomas, Michael L. Brown, Gregory G. Nock, Matthew K. Savitt, Adam P. Keilp, John G. Heeringa, Steven Ursano, Robert J. and Stein, Murray B. 2017. Development, Administration, and Structural Validity of a Brief, Computerized Neurocognitive Battery. Assessment, p. 107319111668982.
Rommelse, Nanda Poelman, Mariska Hartman, Catharina and Hoogeveen, Lianne 2017. Is ADHD een valide diagnose wanneer er sprake is van hoogbegaafdheid?. Neuropraxis, Vol. 21, Issue. 5, p. 113.
Livingston, Lucy Anne and Happé, Francesca 2017. Conceptualising compensation in neurodevelopmental disorders: Reflections from autism spectrum disorder. Neuroscience & Biobehavioral Reviews, Vol. 80, p. 729.
Michelini, Giorgia Kitsune, Glenn L. Cheung, Celeste H.M. Brandeis, Daniel Banaschewski, Tobias Asherson, Philip McLoughlin, Gráinne and Kuntsi, Jonna 2016. Attention-Deficit/Hyperactivity Disorder Remission Is Linked to Better Neurophysiological Error Detection and Attention-Vigilance Processes. Biological Psychiatry, Vol. 80, Issue. 12, p. 923.
Cheung, C. H. M. Rijsdijk, F. McLoughlin, G. Brandeis, D. Banaschewski, T. Asherson, P. and Kuntsi, J. 2016. Cognitive and neurophysiological markers of ADHD persistence and remission. The British Journal of Psychiatry, Vol. 208, Issue. 6, p. 548.
Patros, Connor H.G. Alderson, R. Matt Kasper, Lisa J. Tarle, Stephanie J. Lea, Sarah E. and Hudec, Kristen L. 2016. Choice-impulsivity in children and adolescents with attention-deficit/hyperactivity disorder (ADHD): A meta-analytic review. Clinical Psychology Review, Vol. 43, p. 162.
Pinto, Rebecca Rijsdijk, Fruhling Ouellet-Morin, Isabelle Asherson, Philip McLoughlin, Grainne and Kuntsi, Jonna 2016. The aetiological association between the dynamics of cortisol productivity and ADHD. Journal of Neural Transmission, Vol. 123, Issue. 8, p. 991.
Pinto, Rebecca Rijsdijk, Fruhling Ronald, Angelica Asherson, Philip and Kuntsi, Jonna 2016. The Genetic Overlap of Attention-Deficit/Hyperactivity Disorder and Autistic-like Traits: an Investigation of Individual Symptom Scales and Cognitive markers. Journal of Abnormal Child Psychology, Vol. 44, Issue. 2, p. 335.
Rommelse, Nanda van der Kruijs, Marieke Damhuis, Jochem Hoek, Ineke Smeets, Stijn Antshel, Kevin M. Hoogeveen, Lianne and Faraone, Stephen V. 2016. An evidenced-based perspective on the validity of attention-deficit/hyperactivity disorder in the context of high intelligence. Neuroscience & Biobehavioral Reviews, Vol. 71, p. 21.
Pinto, Rebecca Asherson, Philip Ilott, Nicholas Cheung, Celeste H. M. and Kuntsi, Jonna 2016. Testing for the mediating role of endophenotypes using molecular genetic data in a twin study of ADHD traits. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 171, Issue. 7, p. 982.
Skogan, Annette Holth Zeiner, Pål Egeland, Jens Urnes, Anne-Grethe Reichborn-Kjennerud, Ted and Aase, Heidi 2015. Parent ratings of executive function in young preschool children with symptoms of attention-deficit/-hyperactivity disorder. Behavioral and Brain Functions, Vol. 11, Issue. 1,
Martin, Joanna Hamshere, Marian L. Stergiakouli, Evangelia O'Donovan, Michael C. and Thapar, Anita 2015. Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry, Vol. 56, Issue. 6, p. 648.
Nikolas, Molly A. and Nigg, Joel T. 2015. Moderators of Neuropsychological Mechanism in Attention-Deficit Hyperactivity Disorder. Journal of Abnormal Child Psychology, Vol. 43, Issue. 2, p. 271.
Bender, Stephan Banaschewski, Tobias Roessner, Veit Klein, Christoph Rietschel, Marcella Feige, Bernd Brandeis, Daniel and Laucht, Manfred 2015. Variability of single trial brain activation predicts fluctuations in reaction time. Biological Psychology, Vol. 106, p. 50.
Cheung, Celeste H.M. Rijdijk, Fruhling McLoughlin, Gráinne Faraone, Stephen V. Asherson, Philip and Kuntsi, Jonna 2015. Childhood predictors of adolescent and young adult outcome in ADHD. Journal of Psychiatric Research, Vol. 62, p. 92.
Kitsune, Glenn L. Cheung, Celeste H. M. Brandeis, Daniel Banaschewski, Tobias Asherson, Philip McLoughlin, Gráinne and Kuntsi, Jonna 2015. A Matter of Time: The Influence of Recording Context on EEG Spectral Power in Adolescents and Young Adults with ADHD. Brain Topography, Vol. 28, Issue. 4, p. 580.
Twin and sibling studies have identified specific cognitive phenotypes that may mediate the association between genes and the clinical symptoms of attention deficit hyperactivity disorder (ADHD). ADHD is also associated with lower IQ scores. We aimed to investigate whether the familial association between measures of cognitive performance and the clinical diagnosis of ADHD is mediated through shared familial influences with IQ.
Multivariate familial models were run on data from 1265 individuals aged 6–18 years, comprising 920 participants from ADHD sibling pairs and 345 control participants. Cognitive assessments included a four-choice reaction time (RT) task, a go/no-go task, a choice–delay task and an IQ assessment. The analyses focused on the cognitive variables of mean RT (MRT), RT variability (RTV), commission errors (CE), omission errors (OE) and choice impulsivity (CI).
Significant familial association (rF) was confirmed between cognitive performance and both ADHD (rF=0.41–0.71) and IQ (rF=−0.25 to −0.49). The association between ADHD and cognitive performance was largely independent (80–87%) of any contribution from etiological factors shared with IQ. The exception was for CI, where 49% of the overlap could be accounted for by the familial variance underlying IQ.
The aetiological factors underlying lower IQ in ADHD seem to be distinct from those between ADHD and RT/error measures. This suggests that lower IQ does not account for the key cognitive impairments observed in ADHD. The results have implications for molecular genetic studies designed to identify genes involved in ADHD.
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