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Thyroid dysfunction in institutionalised Down's syndrome adults

Published online by Cambridge University Press:  09 July 2009

H. G. Kinnell ,
N. Gibbs ,
J. D. Teale  and
J. Smith
H. G. Kinnell*
Affiliation:
Botleys Park Hospital, Chertsey, Royal Surrey County Hospital, Guildford, St. Luke's Hospital, Guildford and May Day Hospital, Croydon
N. Gibbs
Affiliation:
Botleys Park Hospital, Chertsey, Royal Surrey County Hospital, Guildford, St. Luke's Hospital, Guildford and May Day Hospital, Croydon
J. D. Teale
Affiliation:
Botleys Park Hospital, Chertsey, Royal Surrey County Hospital, Guildford, St. Luke's Hospital, Guildford and May Day Hospital, Croydon
J. Smith
Affiliation:
Botleys Park Hospital, Chertsey, Royal Surrey County Hospital, Guildford, St. Luke's Hospital, Guildford and May Day Hospital, Croydon
*
1Address for correspondence: Dr H. G. Kinnell, Consultant Psychiatrist, Botleys Park Hospital, Guildford Road, Chertsey, Surrey KTI6 OQA.
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Synopsis

This study of 111 institutionalised Down's syndrome subjects and 74 controls found a relatively low risk of hypothyroidism in both groups compared with certain other studies of Down's subjects, which found very high rates of thyroid hypofunction. However, the Down's syndrome group had a significantly raised risk of hypothyroidism (9%), hyperthyroidism (1·8%) and the presence of thyroid microsomal antibodies (29%) compared with the controls and with laboratory reference data. It is recommended that thyroid function testing should be routine in older Down's syndrome subjects, with special attention being given to the clinical status of those with microsomal antibodies present.

Type
Research Article
Information
Psychological Medicine , Volume 17 , Issue 2 , May 1987 , pp. 387 - 392
Copyright
Copyright © Cambridge University Press 1987

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