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What kinds of things are psychiatric disorders?

  • K. S. Kendler (a1), P. Zachar (a2) and C. Craver (a3)
  • DOI:
  • Published online: 22 September 2010

This essay explores four answers to the question ‘What kinds of things are psychiatric disorders?’ Essentialist kinds are classes whose members share an essence from which their defining features arise. Although elegant and appropriate for some physical (e.g. atomic elements) and medical (e.g. Mendelian disorders) phenomena, this model is inappropriate for psychiatric disorders, which are multi-factorial and ‘fuzzy’. Socially constructed kinds are classes whose members are defined by the cultural context in which they arise. This model excludes the importance of shared physiological mechanisms by which the same disorder could be identified across different cultures. Advocates of practical kinds put off metaphysical questions about ‘reality’ and focus on defining classes that are useful. Practical kinds models for psychiatric disorders, implicit in the DSM nosologies, do not require that diagnoses be grounded in shared causal processes. If psychiatry seeks to tie disorders to etiology and underlying mechanisms, a model first proposed for biological species, mechanistic property cluster (MPC) kinds, can provide a useful framework. MPC kinds are defined not in terms of essences but in terms of complex, mutually reinforcing networks of causal mechanisms. We argue that psychiatric disorders are objectively grounded features of the causal structure of the mind/brain. MPC kinds are fuzzy sets defined by mechanisms at multiple levels that act and interact to produce the key features of the kind. Like species, psychiatric disorders are populations with central paradigmatic and more marginal members. The MPC view is the best current answer to ‘What kinds of things are psychiatric disorders?’

Corresponding author
*Address for correspondence: K. S. Kendler, M.D., Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Medical School, PO Box 980126, Richmond, VA 23298-0126, USA. (Email:
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D Borsboom (2008). Psychometric perspectives on diagnostic systems. Journal of Clinical Psychology 64, 10891108.

R Boyd (1991). Realism, antifoundationalism and the enthusiasm for natural kinds. Philosophical Studies 61, 127148.

CF Craver (2007). Explaining the Brain. Clarendon Press: Oxford.

AS Evans (1993). Causation and Disease: A Chronological Journey. Plenum Publishing Corporation/Plenum Medical Book Company: New York, NY.

KS Kendler (2005). ‘A gene for …’: the nature of gene action in psychiatric disorders. American Journal of Psychiatry 162, 12431252.

KS Kendler (2008). Explanatory models for psychiatric illness. American Journal of Psychiatry 165, 695702.

KS Kendler , M Gatz , C Gardner , N Pedersen (2006). A Swedish national twin study of lifetime major depression. American Journal of Psychiatry 163, 109114.

G Koob , MJ Kreek (2007). Stress, dysregulation of drug reward pathways, and the transition to drug dependence. American Journal of Psychiatry 164, 11491159.

GF Koob (2009). Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology 56 (Suppl. 1), 1831.

SJ Russo , MS Mazei-Robison , JL Ables , EJ Nestler (2009). Neurotrophic factors and structural plasticity in addiction. Neuropharmacology 56 (Suppl. 1), 7382.

H Sass (2007). The German Anthology of Psychiatric Texts. World Psychiatric Association: Chene-Bourg, Switzerland.

PF Sullivan , MC Neale , KS Kendler (2000). Genetic epidemiology of major depression: review and meta-analysis. American Journal of Psychiatry 157, 15521562.

BC Van Fraassen (1976). To save the phenomena. Journal of Philosophy 73, 623632.

RA Wilson , MJ Barker , I Brigandt (2007). When traditional essentialism fails: biological natural kinds. Philosophical Topics 35, 189215.

P Zachar (2003). The practical kinds model as a pragmatist theory of classification. Philosophy, Psychology and Psychiatry 9, 219227.

P Zachar , KS Kendler (2007). Psychiatric disorders: a conceptual taxonomy. American Journal of Psychiatry 164, 557565.

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Psychological Medicine
  • ISSN: 0033-2917
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