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Where are the breaks in translation from theory to clinical practice (and back) in addressing depression? An empirical graph-theoretic approach

Published online by Cambridge University Press:  18 December 2018

Greg J. Siegle Open the ORCID record for Greg J. Siegle [Opens in a new window] ,
Angélique O.J. Cramer ,
Nees Jan van Eck ,
Philip Spinhoven ,
Steven D. Hollon ,
Johan Ormel ,
Marlene Strege Open the ORCID record for Marlene Strege [Opens in a new window]  and
Claudi L. H. Bockting
Greg J. Siegle*
Affiliation:
University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
Angélique O.J. Cramer
Affiliation:
Tilburg University, Tilburg, Netherlands
Nees Jan van Eck
Affiliation:
Leiden University, Leiden, Netherlands
Philip Spinhoven
Affiliation:
Leiden University, Leiden, Netherlands
Steven D. Hollon
Affiliation:
Vanderbilt University, Nashville, TN, USA
Johan Ormel
Affiliation:
University of Groningen, Groningen, Netherlands
Marlene Strege
Affiliation:
Virginia Tech, Nashvile, CA, USA
Claudi L. H. Bockting
Affiliation:
Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
*
Author for correspondence: Greg J. Siegle, E-mail: gsiegle@pitt.edu
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Abstract

Background

Research in depression has progressed rapidly over the past four decades. Yet depression rates are not subsiding and treatment success is not improving. We examine the extent to which the gap between science and practice is associated with the level of integration in how depression is considered in research and stakeholder-relevant documents.

Methods

We used a network-science perspective to analyze similar uses of depression relevant terms in the Google News corpus (approximately 1 billion words) and the Web of Science database (120 000 documents).

Results

These analyses yielded consistent pictures of insular modules associated with: (1) patient/providers, (2) academics, and (3) industry. Within academia insular modules associated with psychology, general medical, and psychiatry/neuroscience/biology were also detected.

Conclusions

These analyses suggest that the domain of depression is fragmented, and that advancements of relevance to one stakeholder group (academics, industry, or patients) may not translate to the others. We consider potential causes and associated responses to this fragmentation that could help to unify and advance translation from research on depression to the clinic, largely involving harmonizing employed language, bridging conceptual domains, and increasing communication across stakeholder groups.

Keywords

Depressiongraph theorytranslation
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 16 , December 2019 , pp. 2681 - 2691
Copyright
Copyright © Cambridge University Press 2018 

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